The knee injury that Atlanta Falcons quarterback Michael Penix Jr. (knee) suffered during his team's Week 11 loss to the Carolina Panthers is "potentially season-ending," according to ESPN's Adam Schefter. Schefter reports that Penix Jr. "will be seeking a second opinion, but it is not encouraging." Knee troubles are particularly worrisome for Penix Jr.'s long-term outlook, as he suffered two ACL tears during his college career. If his 2025 season is indeed over, he will finish the year with 1,982 passing yards, nine touchdowns, and three interceptions across nine games played. Veteran quarterback Kirk Cousins took over for Penix Jr. in Week 11 and would likely be Atlanta's starter for the remainder of the 2025 season. Cousins has struggled so far this year, completing 32 of 52 pass attempts for 250 yards, zero touchdowns, and zero interceptions across three games (one start). There should be more clarity around the exact nature of Penix Jr.'s injury in the coming days, but fantasy managers should prepare for Cousins to get the start in Week 12 against the New Orleans Saints and beyond.

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Kansas City Chiefs running back Kareem Hunt scored a rushing touchdown for the third consecutive game in his team's 22-19 Week 11 loss to the Denver Broncos. The 30-year-old finished the game with 13 carries for 59 yards and one score. With Isiah Pacheco (knee) sidelined by a knee injury, Hunt has taken over as Kansas City's lead rusher in the team's last two games. While he's not an explosive player at this point in his career, Hunt has six rushing touchdowns on the season and has proven to be an effective goal-line rusher. Pacheco could return in Week 12 against the Indianapolis Colts, which would cause Hunt to lose a few touches. However, Hunt seems likely to retain his goal-line role even when Pacheco gets back on the field. In leagues where Hunt remains available, he could be worth targeting on the waiver wire as a touchdown-dependent flex option for fantasy managers.

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Arizona Cardinals running back Trey Benson (knee) has been on Injured Reserve since Week 4 due to a knee injury. However, Cardinals head coach Jonathan Gannon indicated leading into Week 11 that Benson is a candidate to have his activation window opened in the near future. That could mean Benson has a chance to return for Arizona's Week 12 matchup against the Jacksonville Jaguars, although that's far from a guarantee at this point. With Cardinals running back James Conner (ankle) out for the season, Benson profiles as the team's RB1 upon his return. In leagues where he is available, Benson may be worth targeting on the waiver wire for the stretch run of the fantasy season. If he remains out in Week 12, Arizona will likely continue splitting backfield work between Bam Knight, Emari Demercado, and Michael Carter.

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Pittsburgh Steelers running back Jaylen Warren (ankle) was forced to exit early from his team's 34-12 Week 11 win over the Cincinnati Bengals due to an ankle injury. However, Warren said after the game that he "could have (played), but (not returning) was part of being smart," per Chris Adamski of the Pittsburgh Tribune-Review. Warren's status for Week 12 against the Chicago Bears is unclear, but it seems he may have avoided a serious injury. Before leaving the game, Warren recorded 67 scrimmage yards on 12 touches. Steelers running back Kenneth Gainwell took advantage of the additional playing time in Warren's absence, hauling in seven receptions for 81 yards and two touchdowns to go along with 24 rushing yards on nine carries. The Steelers' running back situation will be one for fantasy managers to closely monitor this week. If Warren is unable to go, Gainwell could be a must-start fantasy running back in Week 12 against Chicago.

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New York Giants running back Devin Singletary scored his first two rushing touchdowns of the season in his team's Week 11 loss to the Green Bay Packers, finishing the game with 16 carries for 44 yards and two scores. With Giants running back Cam Skattebo (ankle) lost for the season with an ankle injury, Singletary has now recorded double-digit touches in three straight games. The 28-year-old appears to be in a timeshare with Tyrone Tracy Jr. in the New York backfield, as Tracy Jr. recorded 23 touches against Green Bay. Tracy Jr.'s presence limits Singletary's upside, particularly as a pass-catcher. However, the veteran Singletary could be the preferred option at the goal line. Heading into a Week 12 matchup against the Detroit Lions, Singletary could be a flex option for fantasy managers to consider off the waiver wire.

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The NFL will be reviewing the on-field incident that occurred between Cincinnati Bengals wide receiver Ja'Marr Chase and Pittsburgh Steelers safety Jalen Ramsey towards the end of the Week 11 matchup between the two teams, per NFL Network's Ian Rapoport. Ramsey was ejected from the game after throwing a punch at Chase, and after the game, he told reporters that Chase spat on him. There's a video circulating where it certainly looks as though that may have been the case, although it will be up to the NFL to make that final determination. Rapoport mentions that "precedent is there" for a suspension to be levied for spitting on an opponent, referencing the incident from earlier this season where Philadelphia Eagles defensive lineman Jalen Carter spat on Dallas Cowboys quarterback Dak Prescott. While nothing has been determined yet, fantasy managers should be aware that Chase could be in danger of missing Cincinnati's Week 12 matchup against the New England Patriots.

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New York Giants quarterback Jaxson Dart (concussion) missed his team's Week 11 loss to the Green Bay Packers due to a concussion. When asked about Dart's status for practice leading into New York's Week 12 matchup against the Detroit Lions, interim Giants head coach Mike Kafka said Dart remains in the league's concussion protocol. While Dart could clear the protocol in time for Week 12, it does not appear that the team knows exactly what his status will be at this time. With Dart sidelined in Week 11, veteran quarterback Jameis Winston took over under center for the Giants. Winston completed 19 of 29 pass attempts for 201 yards, zero touchdowns, and one interception against the Packers. If Winston gets another start against Detroit, he could be a solid starting fantasy QB option in two-quarterback league formats.

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Arizona Cardinals wide receiver Michael Wilson had himself a career day on Sunday, as he set new career-best lines with 15 receptions and 185 receiving yards. The third-year receiver out of Stanford was thrust into duties on Sunday as Marvin Harrison (Appendicitis) and Zay Jones (Achilles) both missed the game. The Cardinals were down early in this contest again, which set up perfectly for Wilson, Jacoby Brissett, and Trey McBride fantasy owners. Brissett threw for 452 yards, and McBride had 115 receiving yards and a touchdown to go along with Wilson's career day. If Harrison continues to miss time and Wilson is thrust into WR1 duties, he is borderline a must-start option in an offense that is racking up a ton of yards over the last three weeks. That being said, the Cardinals face the Jaguars in Week 12, who are stiffer competition than what the Cardinals had in Week 11. Regardless, Wilson is a must-add off the waiver wire right now, and should be comfortably in the WR3 conversation should Harrison miss additional time.

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Tampa Bay Buccaneers running back Sean Tucker exploded for 106 yards and two touchdowns on 19 carries in the Buccaneers' 44-32 loss against the Buffalo Bills. He also hauled in both of his targets for 34 yards and another score. It was a favorable matchup for Tucker against a Bills run defense that has really struggled in 2025 and has allowed the sixth most points to opposing running backs on the season. Still, Tucker made his presence known and out-carried backfield mate Rachaad White 19 to 10 on the afternoon and had the explosion, which was evident by his 43-yard touchdown run and his 28-yard reception touchdown. Should Bucky Irving (shoulder) continue to miss time, Tucker should be considered a low-end RB2 heading into Week 12 based on his volume, opportunities, and recent outburst. The matchup is tough against the Los Angeles Rams, but they did allow 67 rush yards and a score to Kenneth Walker this past Sunday. White will likely remain involved, but is now considered more of an RB3/desperate flex play.

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Green Bay Packers running back Emanuel Wilson stepped into a lead role in the second half on Sunday in the Packers' 27-20 victory over the New York Giants because Josh Jacobs (knee) was injured and did not return in the second half of the game. Reports have suggested that Jacobs' knee injury is not "season-ending." However, he is expected to get additional testing done on Monday, and it appears likely that Wilson will be in line for RB1 duties in this offense, making him a clear, top-25 running back in fantasy football while Jacobs is out. MarShawn Lloyd (hamstring) is also injured, and Wilson is a must-add in all formats, and could be a plug-and-play option for your team as an RB2 or flex spot heading into Week 12 against the Minnesota Vikings. Even with Jacobs healthy in 2025, Wilson has 53 rush attempts and 220 rushing yards on the season, and has been playing roughly 24% of the snaps, so he does have some exposure.

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Jacksonville Jaguars running back Bhayshul Tuten (ankle) exited during the third quarter of Sunday's Week 11 contest against the Los Angeles Chargers with an injury, as the Jaguars went on to dominate the Chargers 35-6. A large part of their dominance was mainly due to the offensive line, Travis Etienne, Tuten, and the Jaguars' defense. At the time of his departure, he was having a career day, rushing for a career high 74 rushing yards and one rushing touchdown on 15 carries. Backfield mate, ETN, also rushed for 73 yards and two touchdowns on 19 carries. According to Jamal St. Cyr, Storts Anchor for News4JAX, when asked about his ankle, Tuten said, "It's good," which is a good sign for his availability heading into Week 12 against the Arizona Cardinals. Tuten was involved fairly early in this contest, and his 15 carries were not due to the game being out of hand. He was clearly splitting touches with ETN early in the game, and it's something to monitor moving forward. Regardless, Tuten becomes a must-add in all formats based on his volume on Sunday, and immediately enters the RB3 conversation, especially if we can expect 8-12 carries from him.

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NFL insider Ian Rapoport mentioned on Good Morning Football that Pittsburgh Steelers quarterback Aaron Rodgers (wrist) is dealing with a fracture in his left wrist, but has not been ruled out for Sunday and is pushing to play. Rodgers missed the entire second half of Sunday's game with the injury, and backup quarterback Mason Rudolph played great, completing 12 of 16 passes for 116 yards and a touchdown. If Rodgers were to miss time, Rudolph, who does have 32 career NFL games under his belt, is a solid backup quarterback who can certainly keep the Steelers afloat. Through 11 weeks of the season, Rodgers has thrown for 1,969 yards, 17 touchdowns, and seven interceptions, and has been a fantasy streamer quarterback at best at this point in his career. The Steelers face the Chicago Bears in Week 12, who allow the third most points to the quarterback position in fantasy football, making Rudolph a solid QB2 streamer if Rodgers doesn't go.

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Dynasty | 49ers quarterback Brock Purdy completed 19-of-26 passes for 200 yards with three touchdowns and no interceptions in a win against the Cardinals. Dynasty Analysis: Arizona's defense isn't exactly looking like the second coming of the 1985 Bears but this was huge for Purdy, who some thought could be in trouble of losing some time to a very impressive Mac Jones. Purdy was solid in this one and looked like the player worthy of the big contract he signed. His ADP slide should stop after this one.

Dynasty | Cardinals wide receiver Michael Wilson had 15 catches on 18 targets for 185 yards with no touchdowns in a loss to the 49ers. Dynasty Analysis: Well, we thought Wilson had a chance to be a decent contributor today. However, we didn't think Jacoby Brissett woud throw the ball 57 times and target him on 18 of those. This was a crazy performance from Wilson, who basically looked like what we thought Marvin Harrison Jr could at some point. While this will undoubtedly be his best day of the year, he'll need to be in lineups next week should Harrison be out again.

Dynasty | Chargers running back Kimani Vidal had 13 rushing yards, two catches and -1 receiving yard in a blowout loss to the Jaguars. Dynasty Analysis: The Jaguars just annihilated the Chargers in a 35-6 beatdown and the game script for Vidal was flipped on its head. With Omarion Hampton possibly returning soon, Vidal needs to perform better the next few weeks to ensure he has a solid role upon Hampton's return. This is likely just a blip on the radar but disappointing, regardless.

Dynasty | Giants quarterback Jameis Winston completed 19-of-29 passes for 201 yards with no touchdowns and one interception in a loss to the Packers. Dynasty Analysis: Winston did what we expected - he kept his team in the game until a late interception ended it. This has been par for the course for famous Jameis, who has as much talent as anyone in the league but has never been able to avoid critical mistakes. He'll be a QB2 moving forward should Jaxson Dart miss more time but his days as a real NFL starter are all but over.

Dynasty | Bucs running back Sean Tucker had 106 rushing yards, two catches, 34 receiving yards and three touchdowns in a loss to the Bills. Dynasty Analysis: Sure, why not? Tucker had just two scores on the season and a high of just 53 rushing yards coming into this one but simply exploded. With Bucky Irving still on the mend, this backfield just got really interesting as Tucker played ahead of Rachaad White for most of the game. It's an interesting development in dynasty leagues as it flips this backfield on its head. Tucker should obviously be owned everywhere but we need to see more before believing this is anything other than an outlier of a performance.

Dynasty | Panthers wide receiver Tetairoa McMillan had eight catches for 130 yards and two touchdowns in a win over the Falcons. Dynasty Analysis: We've said for weeks we believe McMillan is a very solid receiver but may not truly have the chops to be a consistent WR1 in dynasty leagues. Well, this was the performance needed to start to change that narrative. McMillan was fantastic in this one as he routinely made plays to break the hearts of any Atlanta fans. McMillan will be locked and loaded as an option moving forward as he and Bryce Young are cooking with gas.

Dynasty | Broncos running back RJ Harvey had 30 rushing yards, three catches and 20 receiving yards in a win over the Chiefs. Dynasty Analysis: The Broncos won the game on the back of their defense as their offense really didn't do too much. This was a disappointing day for Harvey, who was making his audition as the lead back with JK Dobbins out for the season. On the plus side, Jaleel McLaughlin only had six carries and Harvey looks like a player who should get plenty of opportunities moving forward. His ADP is stable at the moment.

Houston Texans wide receiver Jayden Higgins finished second on the team with 55 receiving yards on Sunday against the Titans, hauling in four of his seven targets. The rookie played 43 snaps compared to 37 for Xavier Hutchinson and 36 for Christian Kirk, getting slightly more work than the two more experienced options. Higgins also had more targets than any other wide receiver except Nico Collins. Higgins has shown good upside over the last few weeks and seems to be climbing the depth chart. He is still high-risk on a short week against the Bills this Thursday, but he does have at least four catches and at least seven targets in three of his last four games. C.J. Stroud (concussion) gives the offense a higher ceiling if he's able to return, but Higgins has worked well with Davis Mills as well, making him a rookie to watch the rest of the season and possibly grab from the waiver wire if you need receiver depth and like his upside.

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