SAN FRANCISCO (AP) - Matt Schaub threw an interception for a touchdown in his fourth straight game, and the San Francisco 49ers led the Houston Texans 14-0 after the first quarter Sunday night.
Tramaine Brock stepped in front of Andre Johnson to intercept Schaub's first pass. Brock ran 18 yards untouched into the end zone to stun Schaub and the Texans again before most fans had even settled into their seats on a relatively warm and windless night at Candlestick Park.
Colin Kaepernick completed four of six passes for 45 yards on San Francisco's opening drive to set up Frank Gore's 1-yard TD run that put Houston in a major hole.
The game started similar to how the Texans' last one ended.
Last week, Schaub threw an interception returned for a score that allowed Seattle to tie the game in the fourth quarter before Houston lost 23-20 in overtime. Fans in Houston have been calling for Schaub to be benched ever since, and some even burned his jersey and posted signs along city streets calling for backup T.J. Yates.
The Texans failed to capitalize even when Schaub looked sharp. He regrouped to complete five of six passes for 32 yards and drive Houston deep into San Francisco territory before a pair of penalties on consecutive third downs. Then, Randy Bullock hooked a 45-yard field goal wide left.
Kaepernick took over and led San Francisco on a 12-play, 65-yard drive that spanned nearly six minutes. He completed a 9-yard pass to Anquan Boldin on third-and-9 before Gore's short TD run.
Both teams entered 2-2 and trying to overcome obstacles.
The 49ers were playing without several key defensive players for the second straight game. All-Pro linebacker Patrick Willis sat out with a strained groin, Nnamdi Asomugha was sidelined with a knee injury and linebacker Aldon Smith is undergoing treatment for substance abuse.
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