Ceddanne Rafaela drilled a two-run homer in the ninth inning to lift the visiting Boston Red Sox to a 3-2 victory over the Baltimore Orioles on Wednesday night.

Jarren Duran singled to lead off the ninth and set up Rafaela's heroics for the Red Sox, who have gone 6-1 on their road trip.

Boston's Roman Anthony led off the game with a homer. Starter Brayan Bello allowed two runs (one earned) over 6 2/3 innings before Greg Weissert (6-4) threw a perfect eighth and Aroldis Chapman struck out the side in the ninth.

Dylan Beavers went 2-for-2 with one run and one RBI for the Orioles. Keegan Akin (4-4) got out of a jam in the eighth before surrendering the go-ahead homer in the ninth.

Yankees 11, Nationals 2

Aaron Judge, Cody Bellinger, Ryan McMahon and Ben Rice homered in a nine-run third inning that lasted about 40 minutes for host New York, which cruised to a rout of Washington.

Trent Grisham and Austin Wells also homered for the Yankees, who scored their second-most runs in an inning this season and had six homers for the fourth time this season.

Yankees starter Max Fried (14-5) threw seven innings of one-run ball. Nationals starter Cade Cavalli allowed eight runs (seven earned) and eight hits in 2 1/3 innings.

Guardians 4, Rays 3

Kyle Manzardo sharply singled to center off Griffin Jax to score automatic runner Angel Martinez in the 10th inning, giving Cleveland a victory over visiting Tampa Bay.

Manzardo's two-out hit was his third walk-off of the season for the Guardians, which won the final two contests in the three-game series. Cleveland had lost six in a row and had a 28-inning scoreless streak until Tuesday.

Tampa Bay had built a 3-1 lead on Brandon Lowe's two-run homer in the third against Slade Cecconi. Steven Kwan's RBI single in the fifth off Drew Rasmussen pulled the Guardians within 3-2. Nolan Jones' ninth-inning home run tied it.

Mariners 4, Padres 3

Eugenio Suarez hit a three-run homer and Seattle held on to defeat visiting San Diego. The Mariners took five of six games from the Padres in the inaugural season of the Vedder Cup, named for Pearl Jam frontman Eddie Vedder, who has ties to both cities.

The Mariners overcame the shortest start of the season for Bryan Woo (12-7), who failed to go six innings for the first time in 26 outings. Woo allowed two runs on six hits in 5 2/3 innings. Andres Munoz gave up a run in the ninth but got his 31st save.

Gavin Sheets and Fernando Tatis Jr. notched two singles and an RBI apiece for the Padres. San Diego starter Yu Darvish (3-4) allowed four runs on four hits in four innings.

Braves 12, Marlins 1

Jurickson Profar homered twice and Ozzie Albies added his third home run in two days as Atlanta claimed the decisive game of a three-game set at Miami.

Michael Harris II and Matt Olson also homered for the Braves, who collected 11 hits and 10 walks. Albies went 2-for-5 with five RBIs and Profar finished 2-for-3 with four runs, three walks and two RBIs. Joey Wentz (5-4) allowed one run over 6 2/3 innings.

Marlins starter Ryan Gusto (7-7) surrendered nine runs, seven hits and five walks in 3 2/3 innings. Jakob Marsee and Derek Hill posted two hits apiece, and Hill's fifth-inning double drove in Miami's run.