Logan O'Hoppe hit a go-ahead two-run single with two outs in the eighth inning, rallying the Los Angeles Angels to a 6-5 victory over the Los Angeles Dodgers on Wednesday in Anaheim, Calif.

The Angels completed their first-ever six-game Freeway Series sweep of their Southern California rivals. The Angels' only other season sweep vs. the Dodgers came when they went 4-0 in 2019.

The Dodgers, who took their fourth straight loss, fell one game behind the San Diego Padres in the National League West. Los Angeles hadn't trailed in the division since April 27.

With the bases loaded and the Dodgers up 5-4 in the eighth, O'Hoppe lined a 103.2 mph fastball from reliever Edgardo Henriquez into center field to drive in Christian Moore and Taylor Ward, who had walked against Justin Wrobleski (4-4).

Tigers 1, White Sox 0

Troy Melton and three relievers combined on a two-hit shutout and Wenceel Perez contributed a run-scoring sacrifice fly to help Detroit defeat the host Chicago.

White Sox pitching limited the Tigers to just five hits, but Detroit capitalized to earn a three-game series victory.

Melton and fellow rookie right-hander Shane Smith of Chicago dueled for the first five innings. Smith allowed two hits and three walks with five strikeouts while throwing 56 of his 92 pitches for strikes.

Brewers 12, Pirates 5

William Contreras drove in four runs and Christian Yelich three more in host Milwaukee's win over Pittsburgh.

It was the Brewers' 12th consecutive win, which is the second time in franchise history the team has won at least 12 in a row. Milwaukee has also won 27 of its last 31 games. Milwaukee starter Brandon Woodruff allowed four hits in four innings with two walks and four strikeouts.

Bryan Reynolds homered twice and drove in all five runs for the Pirates, who lost their fifth straight. Starter Mitch Keller (5-11) took the loss, giving up six runs and eight hits in four innings with two walks and five strikeouts.

Braves 11, Mets 6

Michael Harris II closed out a nine-run fourth inning by hitting a grand slam for visiting Atlanta, which stunned New York in the middle game of a three-game series.

The Braves, who trailed 6-0 after two innings before mounting their biggest comeback of the season, have won five of seven. The Mets took their 12th loss in 14 games.

Jurickson Profar finished 3-for-5 with a three-run double for the Braves. Marcell Ozuna homered and knocked in three runs. Juan Soto homered for the Mets, and Pete Alonso added three hits and two RBIs.

Diamondbacks 6, Rangers 4

Ketel Marte's three-run homer with two outs in the ninth rallied Arizona to the series victory over Texas in Arlington, Texas.

Marte, who also homered in the ninth Tuesday to lift the Diamondbacks to victory, finished 4-for-5 with 4 RBIs. James McCann triggered Arizona's rally with a two-out solo homer off Phil Maton (2-4) in the ninth. John Curtiss (2-0) tossed a scoreless eighth while Andrew Saalfrank claimed his first career save.

Josh Burger hit a two-run homer for the Rangers while Evan Carter added two hits. Texas starter Merrill Kelly, acquired from Arizona at the deadline, went six innings and allowed seven hits and two runs. Zac Gallen gave up five hits and three runs over five innings.

Nationals 8, Royals 7

Daylen Lile went 2-for-5, including the go-ahead RBI, to help Washington avoid a sweep with a win over host Kansas City.

The rookie outfielder knocked a line-drive single off reliever Carlos Estevez (4-5) in the top of the ninth to drive in Luis Garcia Jr. Nationals reliever Jose Ferrer (4-3) held the Royals scoreless in 1 1/3 innings in the eighth and ninth to earn the win.

Both starters went four innings, with Washington right-hander Irvin giving up six runs on seven hits and four walks. Vinnie Pasquantino provided the big blow against him, belting a changeup 410 feet to right field for a three-run homer in the fourth. Meanwhile, the Royals' Seth Lugo allowed seven runs (six earned) on six hits and four walks. Nathaniel Lowe highlighted a five-run Nationals first with a grand slam to right field, and CJ Abrams added a solo shot in the fourth.

Rockies 6, Cardinals 5

Hunter Goodman hit a two-run pinch-hit homer in the ninth to lift visiting Colorado past St. Louis.

Braxton Fulford drove in two runs and Mickey Moniak went 2-for-5 with a homer as the Rockies won their second straight game and snapped an eight-game losing streak.

Alec Burleson hit a two-run homer for the Cardinals, who lost for the fourth time in six games against the Rockies this season. Pedro Pages drove in two runs and Lars Nootbaar homered and scored twice.

Padres 11, Giants 1

Jake Cronenworth and Fernando Tatis Jr. contributed two-run singles to a seven-run second inning, Nick Pivetta pitched into the seventh for his 12th win of the year, and San Diego completed a three-game road sweep of San Francisco.

Six consecutive Padres reached base against Giants starter Kai-Wei Teng (1-2) with one out in the second, with Cronenworth's single making it 2-0 before Tatis' single doubled the score.

Pivetta (12-4) took a shutout into the bottom of the seventh before a triple by Jung Hoo Lee and a sacrifice fly by Christian Koss completed the game's scoring.

Twins 4, Yankees 1

Kody Clemens highlighted a three-run sixth-inning rally with a two-run double, Joe Ryan pitched 6 2/3 stellar innings and visiting Minnesota earned a victory at New York.

After a 1-hour, 52-minute delay, the Twins broke a nine-game losing streak to the Yankees. Ryan (12-5) allowed one run on four hits, while Byron Buxton had two hits for Minnesota.

Cody Bellinger homered for the Yankees. Reliever Yerry De los Santos (0-1) was charged with three runs without recording an out.

Orioles 4, Mariners 3

Jackson Holliday rapped a two-out, run-scoring double in the bottom of the ninth inning as Baltimore edged visiting Seattle.

Ryan Mountcastle homered and pinch hitter Jeremiah Jackson tripled in Baltimore's three-run seventh inning. Trevor Rogers provided seven strong innings before Keegan Akin (4-2) got the win despite blowing a lead.

Despite scoring twice in the top of the ninth, the Mariners had their season-best eight-game winning streak end. Julio Rodriguez and J.P. Crawford each had two hits. Reliever Matt Brash (1-1) took the loss.

Marlins 13, Guardians 4

Jakob Marsee hit two home runs and tied the franchise record with seven RBIs, and Eury Perez remained unbeaten in interleague play as Miami routed host Cleveland.

Marsee, who made his MLB debut Aug. 1, had a three-run shot off Gavin Williams in the first inning and a two-run blast against Kolby Allard (2-2) in the fifth. He tacked on a two-run double in the sixth. The 24-year-old outfielder went 4-for-5 and also stole his sixth base, raising his average to .436. Marsee is the seventh Marlins player to drive in seven runs in a game, the first since Adam Duvall on April 13, 2021. Perez (5-3) worked five innings, giving up four runs on three hits. The righty struck out eight and is 7-0 with a 1.47 ERA in 10 career interleague starts.

The Guardians, who are 10-3 since July 29, got a three-run homer from Gabriel Arias and a leadoff shot by Steven Kwan.

Cubs 4, Blue Jays 1

Cade Horton struck out a career-best eight, Michael Busch and Matt Shaw hit home runs and visiting Chicago defeated Toronto.

Horton (7-3) allowed one run and one hit in 5 2/3 innings while winning his fourth consecutive start. His scoreless streak ended at 28 1/3 innings after he exited in the sixth, when Vladimir Guerrero Jr. hit a two-run double off reliever Andrew Kittredge.

Busch added a sacrifice fly to help the Cubs gain a split of the first two games of the three-game series.

Reds 8, Phillies 0

Hunter Greene returned from a two-month injury stint and tossed six shutout innings while Miguel Andujar stayed red-hot with a grand slam to lead Cincinnati past visiting Philadelphia.

Greene, out since June 3 with a right groin strain, was dominant over the course of his 85-pitch effort, striking out six and walking none. The Reds put the game away with a four-run seventh on Andujar's third homer in four games, a third career grand slam to the seats in left off reliever Jordan Romano.

Cristopher Sanchez (11-4) allowed four runs -- three earned -- matching a season high for a third time this year. The left-hander lost for just the second time in 11 starts since June 8.

Astros 4, Red Sox 1

Hunter Brown pitched 6 2/3 strong innings and his batterymate Yainer Diaz drove in three runs as Houston beat visiting Boston in the rubber match of a three-game series.

Brown (10-5) snapped a six-start winless streak by producing his 15th quality start of the season. Diaz finished 2-for-3 with a two-run home run and an RBI single to pace the Houston offense.

Boston starter Walker Buehler (7-7) allowed four runs on four hits and four walks, with three strikeouts, over six innings.

Rays 8, Athletics 2

Hot sluggers Brandon Lowe and Junior Caminero each bashed a two-run homer and Drew Rasmussen pitched six strong innings to help Tampa Bay top the Athletics in West Sacramento, Calif.

Caminero had two hits, three RBIs and two runs in the series finale as the Rays took two of three from the A's. Rasmussen (10-5) allowed two runs (one earned) and three hits.

Lawrence Butler homered for the A's. J.T. Ginn (2-5) threw 70 pitches while lasting just two innings. He gave up six runs (five earned) on six hits.