Charlotte Hornets centerRyan Kalkbrenner(personal) is available for Wednesday's meeting with the Milwaukee Bucks. He was listed as questionable due to personal reasons. In the first 10 games of his NBA rookie campaign, Kalkbrenner has averaged 9.2 points, 6.6 rebounds, 2.3 blocks, and 1.0 steals across 26.6 minutes per contest. The 23-year-old big man has four blocks in his last five appearances. However, he is not a strong fantasy option for this evening.

Detroit Pistons guard Cade Cunningham (hip) won't play on Wednesday versus the Bulls. The 24-year-old was listed as probable on Tuesday night, but he was quickly downgraded to questionable. He's now ruled out, so his next chance to get on the floor will be on Friday against the visiting Philadelphia 76ers. With Isaiah Stewart (ankle), Ausar Thompson (ankle) and Jalen Duren (ankle) ruled out, the Pistons will need more production from Duncan Robinson, Daniss Jenkins, Javonte Green, Ron Holland II, and Paul Reed.

Sacramento Kings guard Zach LaVine (thigh) won't suit up on Wednesday versus the visiting Hawks. It's unknown how severe the thigh contusion is, although it's apparently bad enough to force the 30-year-old to miss his second game of the 2025 campaign. Under normal circumstances, Domantas Sabonis (rib) and Malik Monk (ankle) would see a few more scoring opportunities. However, both are questionable, meaning Russell Westbrook and Dennis Schroder might have above-average fantasy showings. Nique Clifford, averaging 7.0 points, 5.5 rebounds, and 1.5 steals in two starts this season, can be considered for streaming purposes for those participating in deeper fantasy formats. LaVine's next chance to play will be on Friday in Minnesota.

Chicago Bulls guard Josh Giddey (ankle) will be out for Wednesday's road tilt against the Detroit Pistons due to a right-ankle sprain. This evening's matchup will be the second game in a row he will miss. Ayo Dosunmu, Kevin Huerter, and Tre Jones are expected to see additional minutes in his place. Giddey has been excellent this season, averaging 21.4 points, 9.6 rebounds, 9.3 assists, and 1.0 steals in 34.0 minutes per contest. His next opportunity to return comes Sunday against the Jazz.

Shams Charania of ESPN reports that Philadelphia 76ers forward Paul George (knee) is in the final stage of his return process and will be re-evaluated later this week. George is moving closer to making his season debut, but team doctors want him to build additional strength in his left quadriceps before granting full clearance, per Charania. The veteran forward is coming off an injury-plagued 2024-25 campaign, during which he averaged 16.2 points, 5.3 rebounds, 4.3 assists, and 1.8 steals in 32.0 minutes per contest.

According to Keith Pompey of The Philadelphia Inquirer, Philadelphia 76ers centerJoel Embiid(knee) doesn't have structural issues in his right knee and is considered day-to-day. Embiid was out of action during Tuesday's win versus the Celtics due to right knee soreness. However, Wednesday's good news for the big man could lead him to play on Friday against the Pistons. If Embiid is unable to suit up, Andre Drummond will likely continue to start at center.

Milwaukee Bucks forward/center Giannis Antetokounmpo (knee) will be unavailable for Wednesday's matchup against the Charlotte Hornets due to left knee patellar tendinopathy. The 30-year-old has missed only one game this season but will sit out tonight for maintenance purposes. Through 10 outings, Antetokounmpo has averaged 33.4 points, 11.9 rebounds, 6.2 assists, and 1.3 blocks across 32.9 minutes per contest. With Giannis sidelined, Ryan Rollins, Kyle Kuzma, and Bobby Portis could all gain a bump in DFS value.

According to Shams Charania of ESPN, Los Angeles Clippers guard Bradley Beal (hip) has sustained a fracture in his left hip and will undergo season-ending surgery. The injury occurred during Saturday's 114-103 loss to the Suns. Beal was unavailable for Monday's 105-102 loss to the Hawks and further imaging confirmed the fracture. In his shortened first campaign with the Clippers, the 32-year-old struggled to make much of a fantasy impact, averaging 8.2 points and 1.7 assists in 20.0 minutes per game. With Beal now sidelined for the remainder of the season, veteran guards James Harden and Kris Dunn are expected to shoulder increased backcourt responsibilities for Los Angeles.

Los Angeles Clippers guard Bradley Beal (hip) will remain out Wednesday against the Nuggets, marking his second straight absence. Head coach Tyronn Lue admitted there's concern Beal could miss additional time. Even when healthy, Beal has struggled to make a fantasy impact, averaging just 8.2 points, 1.7 assists, and 1.2 threes in 20 minutes per game on 37.5 percent shooting. With both Beal and Kawhi Leonard (ankle) sidelined, James Harden should continue to dominate the offense, fresh off a stellar 35-point, 11-assist outing. Kris Dunn is a sneaky short-term add for assists and steals, as his defensive activity and secondary playmaking fit well in the current rotation. Bogdan Bogdanovic and Derrick Jones Jr. should also see bumps in usage. Beal remains a big name but is over-rostered at this point, especially in standard leagues where his floor has been far too low.

Atlanta Hawks guard Nickeil Alexander-Walker (back) is questionable for Wednesday's matchup against the Kings after missing the last two games. Before the injury, he was thriving in an expanded role without Trae Young, averaging 17.6 points, 3.2 assists, 2.6 rebounds, 1.0 steal, and 2.0 threes in just over thirty minutes per game while shooting 43.8 percent from the field and 85.0 percent from the line. If cleared, Alexander-Walker should reclaim his starting spot and continue as one of Atlanta's top scoring options. If he remains out, Keaton Wallace will likely stay at point guard, offering assists and energy when given steady minutes, while Dyson Daniels shifts to shooting guard with added playmaking responsibility. Vit Krejci and Luke Kennard can also provide three-point help in deeper formats. Alexander-Walker remains a hold across most leagues due to his scoring consistency and opportunity.

Detroit Pistons forward Tobias Harris (ankle) will remain sidelined Wednesday against the Bulls. Head coach J.B. Bickerstaff noted that Harris is "trending in the right direction," but he still has no firm timetable after missing five straight games. Before the injury, Harris averaged 13.5 points, 6.0 rebounds, and 2.8 assists in just over 32 minutes per game, providing steady mid-range scoring and reliable free-throw efficiency at 94.0 percent. His absence continues to open up opportunities for Cade Cunningham (hip) and Jalen Duren (ankle) to dominate usage, while Duncan Robinson's floor spacing keeps him relevant in deeper leagues. Caris LeVert, now off the injury report, profiles as the short-term add for points and threes, while rookie Ron Holland II offers streaming upside in rebounds and defensive stats until Detroit's frontcourt gets healthy.

Cleveland Cavaliers forward Jaylon Tyson (head) has been ruled out Wednesday against the Miami Heat due to a concussion. It's an untimely setback for Cleveland, who are already missing Darius Garland (toe), Donovan Mitchell (rest), and Evan Mobley (rest). Tyson has quietly been one of the Cavaliers' bright spots, averaging 11.1 points, 4.0 rebounds, 1.8 assists, and 2.2 threes per game on an efficient 48.9 percent shooting from the field and 46.2 percent from deep. He's been producing steady two-way value even when Garland was briefly active, showing poise and defensive versatility. With Tyson sidelined, expect Sam Merrill and De'Andre Hunter to see more wing minutes and perimeter looks, while Lonzo Ball and Craig Porter Jr. handle additional playmaking duties. Tyson's concussion will likely cost him multiple games, making him a hold in deeper formats but a temporary drop candidate in standard leagues if roster flexibility is limited.

Washington Wizards guard Bilal Coulibaly (calf) will remain sidelined Wednesday against the Rockets due to a calf contusion, marking his fourth straight missed game since re-injuring it on Nov. 5. The third-year wing had shown encouraging all-around growth before the setback, averaging 10.5 points, 4.8 rebounds, 3.3 assists, 1.0 steal, 1.0 block, and 1.3 threes in just under 24 minutes per game. In his absence, CJ McCollum has rediscovered his rhythm after an early-season slump, averaging 30.7 points and 6.0 assists over his last three contests while shooting 51 percent from the field and 81 percent at the line. Expect McCollum to continue leading the offense, while Kyshawn George remains a strong fantasy add thanks to his steady scoring, rebounding, and defensive activity. Corey Kispert provides reliable perimeter shooting, and Alexandre Sarr continues to offer value as a rebounding anchor. Coulibaly is a hold only for managers with deep benches.

Miami Heat forward/center Bam Adebayo (toe) will miss a fourth straight game on Wednesday against the Cleveland Cavaliers. The two-time Olympic champion recently sprained his left big toe. Adebayo was initially wearing a walking boot, but he didn't have one on when getting some practice reps in on Tuesday. This is an encouraging development and could indicate that the Heat star will be ready to return to action soon. Until then, Kel'el Ware will continue to start at center. He had a big game on Monday against the Cavaliers, finishing a 140-138 overtime victory with 14 points and a career-high 20 rebounds. On Wednesday, Ware will face an Evan Mobley-less Cleveland frontcourt, giving him a good opportunity to do more damage in the matchup.

Dallas Mavericks guard/forward Cooper Flagg (thumb) will be in the lineup on Wednesday night against the Phoenix Suns. The exciting rookie hurt his right thumb on a dunk attempt in Saturday's win over the Washington Wizards. Despite the injury, Flagg produced an outstanding display in Monday's matchup against the Milwaukee Bucks and is good to go again on Wednesday. Flagg led the Mavericks in points, rebounds, and assists on Monday night. He's experiencing some growing pains early in his NBA career, as Flagg's shooting has been inconsistent, but the 18-year-old is providing solid fantasy production. So far, Flagg has averaged 15.0 points, 6.8 rebounds, 3.1 assists, and 1.3 steals.

Dallas Mavericks forward/center Anthony Davis (calf) is considered questionable for Wednesday's Western Conference showdown against the Phoenix Suns. Following the firing of general manager Nico Harrison, the Mavericks start a new era on Wednesday night, but Davis might miss the game due to a lingering calf issue, which has kept him sidelined for six games already. Dallas' frontcourt has battled injuries throughout the season, giving rookie Moussa Cisse a chance to make an impact. He has notched 7.3 points, 7.0 rebounds, and 2.0 blocks per game over the last three contests.

Cleveland Cavaliers point guard Darius Garland (toe) will be sidelined on Wednesday against the Miami Heat. After having surgery on his left big toe in the summer, Garland re-injured it against the Heat on Monday, playing only 19 minutes. He has played in only three games this season, averaging 13.0 points and 5.0 assists in 24.3 minutes. Lonzo Ball and Craig Porter Jr. will handle the point guard minutes in Wednesday's contest. Additionally, Garland's absence is likely to increase the offensive usage of players like Sam Merrill and De'Andre Hunter, especially with Donovan Mitchell (rest) and Evan Mobley (rest) also out on Wednesday.

Cleveland Cavaliers forward/center Evan Mobley (rest) will not feature in Wednesday's game against the Miami Heat. Cleveland has two games in two nights and will rest Mobley alongside Donovan Mitchell. This means the Cavaliers will be without their two highest scorers. Mobley is averaging a career-high 20.1 points with 8.6 rebounds. As usual, the 24-year-old has also been a big presence defensively, notching 1.5 steals and 1.5 blocks per game. The frontcourt could also be without Larry Nance Jr. (knee), who is listed as questionable on the injury report, raising the fantasy potential of Jarrett Allen, Dean Wade, and Thomas Bryant.

Cleveland Cavaliers guard Donovan Mitchell (rest) won't play in Wednesday's clash against the Miami Heat. The Cavaliers will keep him out of action for the first leg of a back-to-back. Mitchell leads his team with averages of 30.4 points and 5.4 assists, having shot over 50 percent from the field during a hot start to the campaign. Cleveland's backcourt also won't have the services of Darius Garland (toe), putting the spotlight on Lonzo Ball and Sam Merrill. Evan Mobley (rest) will be in street clothes as well on Wednesday night, opening up even more offensive opportunities for the rest of the Cavaliers.

Detroit Pistons forward/center Isaiah Stewart (ankle) is listed as doubtful for Wednesday's game against the Bulls. With Tobias Harris (ankle) sidelined, Stewart had been starting. However, he tweaked his ankle during the win over the Brooklyn Nets on November 7 and will now miss his third-straight contest. With Ausar Thompson (ankle) on the shelf, Ron Holland II may continue to see some action in the starting lineup. Unfortunately, Holland has averaged only 7.0 points as a starter, so he has some work to do before finding a place in any fantasy lineup.