Pacers' F Pascal Siakam scored 30 points on 13-of-23 shooting in a 123-120 win over New Orleans on Wednesday, Oct. 21. Siakam is owned in only 72.2% leagues.

Grizzlies' G Ty Jerome scored 45 points on 17-of-25 shooting in a 123-103 win over the Jazz on Wednesday, Oct. 21. Jerome is owned in only 11.1% leagues.

Brooklyn Nets' F Julius Randle scored 33 points on 11-of-18 shooting in a 103-110 loss to the Hornets on Wednesday, Oct. 21. Randle is owned in only 66.7% leagues.

Minnesota's G Anthony Edwards recorded a double-double, scoring 45 points and grabbing 10 rebounds in a 131-106 win over Miami on Wednesday, Oct. 21.

Sacramento Kings guard Malik Monk (ankle) has been ruled out for Wednesday's season opener against the Los Angeles Clippers, according to Sean Cunningham. Monk did not appear during the preseason and has been managing left ankle soreness throughout training camp. He averaged 12.5 points, 3.0 assists, and 2.0 three-pointers across 62 games last season. With Ben Simmons (Achilles) also out for the season, Sacramento's backcourt depth is already being tested. Nique Clifford and Emanuel Sharp should pick up additional minutes, with Clifford carrying the stronger fantasy outlook after averaging 8.6 points and 3.8 rebounds as a rookie.

Portland Trail Blazers forward/center Micah Potter (illness) is available for Wednesday's season opener against the Phoenix Suns. He missed the preseason finale while sick. The 28-year-old sits behind Donovan Clingan, Robert Williams III, and Yang Hansen on the center depth chart, so minutes will be hard to find. Potter's best path is his shooting. He hit 42.3 percent of his 3.6 three-point attempts per game with Indiana last season, averaging 9.7 points and 5.0 rebounds in 19.3 minutes. He saw only 10.8 minutes per game this preseason, so fantasy managers can leave him on waivers until injuries thin out Portland's frontcourt.

Phoenix Suns center Khaman Maluach will start Wednesday's season opener against the Portland Trail Blazers, according to The Arizona Republic's Duane Rankin. The 20-year-old gets the opening-night nod over Oso Ighodaro after the two competed throughout camp with Mark Williams (shoulder) sidelined following surgery. Maluach averaged 3.0 points, 2.9 rebounds, and 0.7 blocks in 8.9 minutes across 46 games as a rookie but closed the preseason with seven points and 12 boards in 24 minutes against Utah. If he keeps the job, his rebounding and shot-blocking give him a path to useful fantasy production.

Portland Trail Blazers guard/forward Deni Avdija (ankle) says he will play and start in Wednesday's season opener against the Phoenix Suns, according to The Athletic's Jason Quick. The 25-year-old had been questionable with right ankle soreness after a strong preseason. Avdija averaged career highs of 24.2 points, 6.9 rebounds, and 6.7 assists last season despite shooting 31.8 percent from three. He also dropped 41 points and 12 assists against Phoenix in April's Play-In win. His availability removes a potential spot start for Sidy Cissoko, though sharing creation duties with Ja Morant and Damian Lillard could lower Avdija's usage from last season.

Golden State Warriors guard Stephen Curry (ankle) is available for Wednesday's season opener against the Los Angeles Lakers after tweaking his right ankle during Sunday's open practice. The 38-year-old practiced fully Monday and entered the matchup listed as probable, so the injury never appeared likely to keep him out. With Brandin Podziemski (back) sidelined, Curry should remain at the center of Golden State's offense. He closed the preseason with 20 points, five assists, and four rebounds in 26 minutes against Portland. The bigger fantasy concern is durability after a right knee issue limited him to 43 games last season, when he averaged 26.6 points and 4.7 assists.

Oklahoma City Thunder guard Nikola Topic (back) will miss his second consecutive game Thursday against the Denver Nuggets. Topic still has no timetable for his return and could be sidelined for an extended period. The 21-year-old has endured a difficult start to his NBA career, suffering a torn left ACL that wiped out his rookie season, receiving a testicular cancer diagnosis that delayed his debut until February, and undergoing offseason back surgery. Topic has appeared in just 10 NBA games thus far and remains off the fantasy radar in most formats.

The Dallas Mavericks announced that guard/forward Jett Howard (calf) will miss Wednesday's regular-season opener against the Houston Rockets due to right calf tightness. The 23-year-old's next opportunity to make his Mavericks debut comes Friday against the Indiana Pacers. Before joining Dallas, Howard spent three seasons with the Orlando Magic, averaging 4.5 points and 1.2 rebounds in 11.0 minutes per contest. Howard is unlikely to have a significant fantasy impact once healthy, as he is expected to play a limited role in Dallas' rotation.

Memphis Grizzlies forward/center Isaiah Stewart (ankle) will miss Wednesday's regular-season opener against the Utah Jazz. Stewart continues to deal with an ankle injury and will have to wait to make his regular-season debut with his new team. His next chance to suit up comes Friday against the Golden State Warriors. The 25-year-old was acquired from Detroit during the offseason after averaging 10.0 points, 5.0 rebounds, and 1.6 blocks last season while finishing seventh in Sixth Man of the Year voting. With Stewart sidelined, Taylor Hendricks and Quinten Post could see additional frontcourt minutes, potentially providing a short-term boost to their fantasy value.

Per Khobi Price of The California Post, Los Angeles Lakers guard Collin Sexton (calf) is unavailable for Wednesday's regular-season opener against the Golden State Warriors. The 27-year-old won't make his Lakers debut because of a calf strain. His next chance to suit up comes on Friday against the Clippers. Quentin Grimes and Jake LaRavia will likely get extra minutes while Sexton is out. Once healthy, Sexton's fantasy upside could be limited in 2026-27, with Luka Doncic and Austin Reaves expected to handle the bulk of the Lakers' offensive responsibilities.

Golden State Warriors forward/center Charles Bassey (knee) will miss Wednesday's regular-season opener against the Los Angeles Lakers. Bassey is dealing with right patellar tendinopathy and is considered day-to-day. With Kristaps Porzingis' (undisclosed) future in question, Bassey could take on a larger frontcourt role than expected once healthy. However, his fantasy value will likely remain limited unless he can secure consistent minutes in Golden State's rotation.

According to ESPN's Shams Charania, the Golden State Warriors have begun exploring trade options for center Kristaps Porzingis (illness), who is seriously contemplating his basketball future as he deals with recurring symptoms of postural orthostatic tachycardia syndrome (POTS). The 31-year-old remains sidelined indefinitely after missing training camp and the entire preseason. Porzingis averaged 16.1 points, 5.3 rebounds, 2.3 assists, and 1.1 blocks in 15 games with Golden State last season. His uncertain playing status and potential departure make him a risky fantasy option heading into the 2026-27 campaign.

Golden State Warriors guard Brandin Podziemski (back) will miss Wednesday's regular-season opener against the Los Angeles Lakers due to back soreness. The 23-year-old's absence comes as a surprise after he appeared in all 82 games last season, making him one of Golden State's most durable rotation players. His next opportunity to suit up will be Friday against the Memphis Grizzlies. Podziemski averaged a career-high 13.8 points in 28.5 minutes per contest during the 2025-26 campaign and could remain a reliable fantasy contributor once healthy.

Indiana Pacers guard T.J. McConnell (hamstring) will miss Wednesday's regular-season opener against the New Orleans Pelicans. McConnell was sidelined for the entire preseason with a hamstring injury after playing just 56 games last season while dealing with similar issues. Once healthy, the 34-year-old is expected to serve as Indiana's backup point guard, but his return timeline remains unclear.

Indiana Pacers guard/forward Aaron Nesmith (hamstring) will miss Wednesday's regular-season opener against the New Orleans Pelicans. Nesmith was sidelined for Indiana's final two preseason games with a left hamstring strain, and he'll next have the chance to return Friday against the Dallas Mavericks. The 27-year-old averaged 13.8 points, 4.2 rebounds, and 1.9 assists last season while shooting 41.4 percent from the field and 37.9 percent from three-point range. Nesmith is expected to reclaim his starting role once healthy. In the meantime, Jarace Walker, Ben Sheppard, and Kelly Oubre could see increased playing time, making them worth monitoring in deeper fantasy leagues.

Golden State Warriors guard Stephen Curry (ankle) is probable for Wednesday's season opener against the Los Angeles Lakers. Curry rolled his ankle during Sunday's open practice but participated fully Monday, and head coach Steve Kerr expects him to play. The 38-year-old averaged 26.6 points, 4.7 assists, and 4.4 threes in 30.9 minutes across 43 games last season. With Brandin Podziemski (back) and Jimmy Butler III (knee) sidelined, Curry should remain the clear offensive focal point, while De'Anthony Melton could pick up additional backcourt minutes.

Los Angeles Lakers center Walker Kessler (finger) is available for Wednesday's season opener against the Golden State Warriors. The 25-year-old jammed his left pinkie on the backboard early in training camp and will play with a splint after appearing in only two preseason games. He posted 11 points and nine rebounds in 16 minutes in his debut. Kessler played just five games last season before undergoing surgery for a torn left shoulder labrum. He averaged 11.1 points, 12.2 rebounds, and 2.4 blocks in 2024-25, and playing next to Luka Doncic should give him plenty of easy looks around the rim.