Los Angeles Rams wide receiver Cooper Kupp (ankle) is out of his cast and was working with the strength and conditioning/training staff during Wednesday's walkthrough practice. Kupp injured his ankle in the Week 2 loss to the division-rival Arizona Cardinals and missed the Week 3 win over the division-rival San Francisco 49er. He has already been ruled out for Week 4 versus the Chicago Bears this Sunday, but it appears he's making progress. With their bye coming in Week 6, there's a chance that fantasy managers won't have Kupp available for their starting lineups until Week 8 against the Las Vegas Raiders. Fellow wideout Puka Nacua (knee) remains on Injured Reserve, so wideouts Demarcus Robinson, Tyler Johnson, Tutu Atwell and Jordan Whittington will continue sharing targets from quarterback Matthew Stafford.

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San Francisco 49ers head coach Kyle Shanahan said that tight end George Kittle (hamstring) was limited in practice on Wednesday. Kittle injured his hamstring in practice last week and ultimately did not play in the Week 3 loss to the division-rival Los Angeles Rams. His status for this Sunday's contest against the visiting New England Patriots is up in the air, but it's a great sign that he is participating in the first practice of the week. If the 30-year-old can increase his practice level on either Thursday or Friday, he'll give himself a shot to be active in Week 4. Backup TE Eric Saubert caught both of his targets for 41 yards and is a weak TE2 streamer in fantasy if Kittle misses another game. Receiver Jauan Jennings reaped all the benefits with Kittle and Deebo Samuel Sr. (calf) out in Week 3, going for 175 yards and three touchdowns. Kittle is a must-start TE1 whenever he's active.

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Tampa Bay Buccaneers rookie running back Bucky Irving (hamstring) was limited in practice due to a hamstring injury. Drafted in the 2024 NFL Draft, Irving has made a strong impression in the run game so far. In the 26-7 loss to Denver on Sunday, he rushed nine times for 70 yards and caught three passes for 14 yards, contributing while playing 32 percent of the offensive snaps. Rachaad White, who took over twice as many snaps (73 percent), had three fewer carries and one fewer touch than Irving, fueling speculation that the rookie could eventually become Tampa Bay's lead back. Head coach Todd Bowles noted in his Monday press conference that Irving is expected to receive more snaps to evaluate his performance better moving forward. However, it remains uncertain if Irving's hamstring injury will impact their workloads during the Week 4 home game against the Eagles.

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San Francisco 49ers head coach Kyle Shanahan said that quarterback Brock Purdy (back) didn't carry an injury designation after practicing in full on Wednesday. Purdy came out of the Week 3 loss to the division-rival Los Angeles Rams with some minor back soreness on Monday, but he appears to be just fine and should be in the clear to start this weekend for a Week 4 matchup against the New England Patriots. The 24-year-old signal-caller displayed why he should be seen as a high-floor fantasy QB after throwing for 292 yards and three touchdowns in the loss to the Rams while being without running back Christian McCaffrey (Achilles, calf), receiver Deebo Samuel Sr. (calf) and tight end George Kittle (hamstring), arguably his top three targets. Purdy could be without all three for a second straight week against an underrated Pats defense. Consider him a low-end QB1/high-end QB2 in Week 4.

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San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) was unable to practice on Wednesday, according to head coach Kyle Shanahan. Samuel suffered a strained right hamstring in the Week 2 loss to the Minnesota Vikings and hasn't practiced since, also missing the Week 3 loss to the division-rival Los Angeles Rams. The injury was initially expected to keep him out for multiple games, so fantasy managers shouldn't plan on having him for the Week 4 tilt against the New England Patriots, especially with him not practicing on Wednesday. The 28-year-old is a must-start in fantasy lineups on a weekly basis when he's active, but he's probably going to be unavailable for a second straight week. Jauan Jennings should be rostered in all fantasy formats after catching 11 of 12 targets for 175 yards and three touchdowns in the Week 3 win with both Samuel and tight end George Kittle (hamstring) both out.

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Los Angeles Chargers quarterback Justin Herbert (ankle) informed reporters there has been discussion about potentially resting him until the bye week, but he believes that's different from the direction they're heading. Herbert mentioned he feels "less pain" and could participate in 7-on-7 drills today, indicating that his recent setback hasn't significantly hindered his recovery. The Chargers officially listed him as a limited participant in practice. After an MRI on Monday, head coach Jim Harbaugh noted that Herbert's ankle injury is "progressing." The 26-year-old was labeled as questionable heading into last week's game after suffering a high ankle sprain in Week 2 against the Carolina Panthers. He exited during the third quarter of the Week 3 loss to the Pittsburgh Steelers after taking a sack that seemed to aggravate the injury, leading to visible limping. He required treatment in the medical tent and did not return, leaving backup Taylor Heinicke to take over the offense. The Chargers are set to face the Chiefs on Sunday, and the team and Herbert hope for his return.

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Arizona Cardinals rookie wide receiver Marvin Harrison Jr. (quadricep) participated in practice on Wednesday on a limited basis due to a quadricep issue. His inclusion on the Cardinals' first practice report for Week 4 suggests that the team might manage his reps to ensure he's ready for Sunday's game against the Commanders. Fortunately, it is a minor concern, and he will likely play in Week 4. After a slow start to his NFL career, Harrison has found his rhythm over the past two games, totaling nine receptions on 19 targets for 194 yards and three touchdowns. The situation is evolving with the Commanders already in town and practicing at Arizona State following their Monday night game. However, how Harrison is listed on Thursday and Friday' will be crucial for assessing his availability. If the injury is minor, he should be considered a must-start fantasy option against a struggling Commanders' pass defense.

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On Wednesday, the Las Vegas Raiders defensive end Maxx Crosby (ankle) did not participate due to an ankle injury. Crosby sustained a high-ankle sprain on the second-to-last play of the Raiders' thrilling Week 2 comeback victory against the Ravens, leaving him less than 80 percent for the home opener. In the game against the Panthers, Crosby was limited to 82% of the defensive snaps. He hadn't missed a snap in a competitive game since Week 14 of last season, when he played 60% of the snaps during a 63-21 blowout against the Los Angeles Chargers. The last time he logged fewer than 82% of the defensive snaps in a competitive game was in the penultimate game of the 2021 season against the Indianapolis Colts, where he played 81%. Last season, Crosby participated in 95% of the Raiders' defensive snaps, recording a career-high 14.5 sacks, earning second-team All-Pro honors, and making his third consecutive Pro Bowl. His practice participation on Thursday and Friday will provide insight into his availability for Week 4. It's worth noting that the All-Pro defensive end has never missed a game in his career.

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Carolina Panthers rookie running back Jonathon Brooks (knee) is in the final stages of returning to play, according to Sheena Quick of 1340 AM. Brooks suffered a torn ACL in November and has been sidelined since the beginning of training camp. The former second-round pick in this year's draft could return in Week 5 at the earliest, and this new report suggests that could be the case. In his final season at Texas, Brooks ran for 1,139 yards and ten scores and added 286 yards off 25 catches through the air. Fantasy managers should expect the rookie to be eased into game action when he is cleared to return. However, Brooks should eventually become the lead option in the Carolina backfield and could be a valuable fantasy asset down the stretch.

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Houston Texans wide receiver Tank Dell (ribs) was deemed "day-to-day" at practice on Wednesday, according to Jonathan M. Alexander of the NFL. The sophomore wideout was dealing with soreness in his ribs following Sunday's game and was held out of practice on Wednesday as a result. Fantasy managers should continue to monitor Dell's status throughout the week. In Week 3, the Houston product posted a season-high 62 receiving yards on five catches against the Minnesota Vikings. Dell has a favorable matchup against the Jacksonville Jaguars on Sunday, who allowed 47 points on Monday to the Buffalo Bills, and Dell should be viewed as a WR3 with upside if he is able to suit up.

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Cincinnati Bengals wide receiver Ja'Marr Chase (shoulder) is dealing with a shoulder issue, according to Ben Baby of ESPN. Baby further reported that the star wideout would have been deemed a limited participant if the team held a full practice on Wednesday instead of just a walkthrough. Fantasy managers should pay close attention to Chase's status throughout the week, but seeing that he would only have been labeled as a limited participant suggests that this injury is not too severe. After averaging just 48.5 yards through the first two weeks of the season, the former LSU Tiger had a nice breakout game on Monday evening, as he caught six passes for 118 yards and two scores. Fantasy managers should feel comfortable locking in Chase as a high-end WR1 if he is a full-go on Sunday against the Carolina Panthers.

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New Orleans Saints running back Alvin Kamara (ribs, hip) did not practice on Wednesday due to hip and rib injuries, according to Adam Schefter of ESPN. Fantasy managers should continue to monitor Kamara's status throughout the week, but this injury does not seem serious after his workload was not limited in any way in Week 3. Last weekend, Kamara carried the ball 26 times and caught three passes. This was the second time this season he ran the ball at least 20 times and saw at least three targets. The star running back will have two more practices during the week to get himself ready to face the Atlanta Falcons. If Kamara sees his full workload on Sunday, he should be viewed as a safe RB1.

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Washington Commanders running back Austin Ekeler (concussion) was ruled out for this weekend's matchup against the Arizona Cardinals according to JP Finlay of 1067 The Fan. Ekeler suffered a concussion in their Week 3 victory over the Cincinnati Bengals. The 29-year-old will now prepare to return to action in Week 5 when the Commanders host the Cleveland Browns. Before the injury on Monday, Ekeler scored his first touchdown of the campaign and tallied 35 yards on the ground. Fantasy managers should expect Brian Robinson Jr. to see an increased role this weekend and should be viewed as a high-end RB2 as he should have a three-down role.

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Carolina Panthers DE Jadeveon Clowney (non-injury), DE A'Shawn Robinson (knee), CB Lonnie Johnson (hip), OG Damien Lewis (elbow) and DT Shy Tuttle (foot) did not participate in practice Wednesday, Sept. 25. S Nick Scott (quadriceps) was limited during practice.

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Buffalo Bills QB Josh Allen (hand) fully participated in practice Wednesday, Sept. 25. The Bills did not hold a practice Wednesday, so this is an estimation.

Fantasy Spin: Allen has been one of the best players in the NFL during the early part of the season with nine total touchdowns in three games. He is a must-start option in all fantasy leagues.

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Buffalo Bills LB Terrel Bernard (pectoral), OT Tylan Grable (groin) and CB Taron Johnson (forearm) did not participate in practice Wednesday, Sept. 25. CB Kaiir Elam (neck) was limited during practice, while TE Quintin Morris (shoulder) and QB Mitchell Trubisky (knee) fully participated in practice. The Bills did not hold a practice Wednesday, so the practice report is an estimation.

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Carolina Panthers QB Andy Dalton (ankle) fully participated in practice Wednesday, Sept. 25.

Fantasy Spin: Dalton took over the starting job last week and finished with 319 yards and three touchdowns. He probably will not post numbers like that this week but could still be a possible option in two-quarterback leagues.

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Dallas Cowboys S Markquese Bell (ankle) and CB Caelen Carson (shoulder) did not participate in practice Wednesday, Sept. 25, and are listed as doubtful for Week 4. CB C.J. Goodwin (non-injury) did not practice but is not on the injury report. CB Trevon Diggs (foot), DE DeMarcus Lawrence (shoulder), DT Mazi Smith (back) and TE John Stephens (hamstring) fully participated in practice and are not on the injury report.

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The Denver Broncos signed veteran linebackers Kwon Alexander and Zach Cunningham on Wednesday, according to NFL insider Ari Meirov. These moves come after Alex Singleton (knee) was diagnosed with a torn ACL, meaning the will miss the rest of the 2024 season. Alexander has spent time with five organizations, but he played for the Pittsburgh Steelers last season and collected 41 total tackles, one sack, and one interception in nine games. Cunningham, a former second-round pick by the Houston Texans in 2017, spent last year with the Philadelphia Eagles and posted 85 total tackles and a fumble recovery in 13 games. Both will be given opportunities to earn legitimate roles following Singleton's unfortunate injury.

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Philadelphia Eagles wide receivers A.J. Brown (hamstring) and DeVonta Smith (concussion) were not spotted at the start of practice on Wednesday as the star duo deals with a hamstring injury and concussion, respectively. Brown has missed each of the last two games, while Smith took a nasty hit to the head in the Week 3 win over the New Orleans Saints and is at risk of missing Week 4. Wideout Britain Covey (shoulder) was placed on Injured Reserve this week, meaning he must sit out at least four games. Needless to say, the Philadelphia wide receiver room is beginning to get thin. Former Washington Commander Jahan Dotson and rookie Johnny Wilson appear to be next up on the depth chart, but neither is guaranteed to produce strong fantasy showings against the Tampa Bay Buccaneers on Sunday. That said, Brown nor Smith are officially ruled out to this point, so fantasy managers should continue to monitor their practice participation later in the week. Even if both players are out, quarterback Jalen Hurts can still post a solid fantasy outing with rushing production, but his floor and ceiling are likely reduced.

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