

| On IR: | |||
| Tyler Bass | |||
| DeWayne Carter | |||
| Gabriel Davis | |||
| Michael Hoecht | |||
| Landon Jackson | |||
| Josh Palmer | |||
| Jordan Phillips | |||
| Taylor Rapp | |||
| Tyrell Shavers | |||
| Dorian Strong | |||
| On IR - Designated For Return: | |||
| Damar Hamlin | |||
| Ed Oliver | |||
| Curtis Samuel | |||
| Questionable: | |||
| Ty Johnson | Ankle | ||
| Out: | |||
| Maxwell Hairston | Ankle | ||
| Jordan Poyer | Hamstring1 | ||
| On IR: | |||
| T.J. Edwards | |||
| Deion Hankins | |||
| Roschon Johnson | |||
| Dayo Odeyingbo | |||
| Noah Sewell | |||
| Terell Smith | |||
| Ty Summers | |||
| Shemar Turner | |||
| On IR: | |||
| Michael Burton | |||
| J.K. Dobbins | |||
| Matt Henningsen | |||
| Brandon Jones | |||
| Delarrin Turner-Yell | |||
| On IR - Designated For Return: | |||
| Lucas Krull | |||
| Drew Sanders | |||
| On IR: | |||
| Mario Edwards, Jr. | |||
| Folorunso Fatukasi | |||
| Kyonte Hamilton | |||
| Jake Hansen | |||
| Brevin Jordan | |||
| Kaevon Merriweather | |||
| Tim Settle | |||
| Jaylin Smith | |||
| M.J. Stewart | |||
| Physically Unable To Perform: | |||
| Tank Dell | |||
| Jimmie Ward | |||
| On IR: | |||
| Shaun Dolac | |||
| Ahkello Witherspoon | |||
| On IR: | |||
| Marcellas Dial | |||
| Joshua Farmer | |||
| Antonio Gibson | |||
| Darius Harris | |||
| Mack Hollins | |||
| Lan Larison | |||
| Deneric Prince | |||
| Craig Reynolds | |||
| Jaquelin Roy | |||
| On IR - Designated For Return: | |||
| Alex Austin | |||
| Terrell Jennings | |||
| On IR: | |||
| George Holani | |||
| Tory Horton | |||
| Kenny McIntosh | |||
| Ricky White III | |||
| Jacardia Wright | |||
| On IR - Designated For Return: | |||
| Elijah Arroyo | |||
| Chazz Surratt | |||
| Questionable: | |||
| Sam Darnold | Oblique | ||
| On IR: | |||
| Tatum Bethune | |||
| Nick Bosa | |||
| Tre'Vius Hodges-Tomlinson | |||
| Tarron Jackson | |||
| George Kittle | |||
| Nick Martin | |||
| Trent Taylor | |||
| Patrick Taylor | |||
| Mykel Williams | |||
| On IR - Designated For Return: | |||
| Jacob Cowing | |||
| Kurtis Rourke | |||
| Fred Warner | |||
| Physically Unable To Perform: | |||
| Brandon Aiyuk | |||
| Questionable: | |||
| Luke Gifford | Quadricep | ||
| Ricky Pearsall | Knee | ||
| Dee Winters | Ankle | ||
| Out: | |||
| Ji'Ayir Brown | Hamstring | ||