 | Atlanta Falcons (7-9) | at |  | Philadelphia Eagles (9-7) | Thu Sep 5 8:20pm ET | |
 | Buffalo Bills (6-10) | at |  | Baltimore Ravens (10-6) | Sun Sep 8 1:00pm ET | |
 | Cincinnati Bengals (6-10) | at |  | Indianapolis Colts (10-6) | Sun Sep 8 1:00pm ET | |
 | Houston Texans (11-5) | at |  | New England Patriots (11-5) | Sun Sep 8 1:00pm ET | |
 | Jacksonville Jaguars (5-11) | at |  | New York Giants (5-11) | Sun Sep 8 1:00pm ET | |
 | Pittsburgh Steelers (9-6-1) | at |  | Cleveland Browns (7-8-1) | Sun Sep 8 1:00pm ET | |
 | San Francisco 49ers (4-12) | at |  | Minnesota Vikings (8-7-1) | Sun Sep 8 1:00pm ET | |
 | Tampa Bay Buccaneers (5-11) | at |  | New Orleans Saints (13-3) | Sun Sep 8 1:00pm ET | |
 | Tennessee Titans (9-7) | at |  | Miami Dolphins (7-9) | Sun Sep 8 1:00pm ET | |
 | Kansas City Chiefs (12-4) | at |  | Los Angeles Chargers (12-4) | Sun Sep 8 4:05pm ET | |
 | Dallas Cowboys (10-6) | at |  | Carolina Panthers (7-9) | Sun Sep 8 4:25pm ET | |
 | Seattle Seahawks (10-6) | at |  | Denver Broncos (6-10) | Sun Sep 8 4:25pm ET | |
 | Washington Redskins (7-9) | at |  | Arizona Cardinals (3-13) | Sun Sep 8 4:25pm ET | |
 | Chicago Bears (12-4) | at |  | Green Bay Packers (6-9-1) | Sun Sep 8 8:20pm ET | |
 | New York Jets (4-12) | at |  | Detroit Lions (6-10) | Mon Sep 9 7:10pm ET | |
 | Los Angeles Rams (13-3) | at |  | Oakland Raiders (4-12) | Mon Sep 9 10:20pm ET | |
