San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

From RotoBaller

San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.

From RotoBaller

San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.

From RotoBaller

San Francisco 49ers running back Isaac Guerendo entered the 2025 season as a prime handcuff for fantasy managers who were looking to score Christian McCaffrey at a discount early in drafts. However, Guerendo's fantasy value took a massive hit when the Niners acquired Brian Robinson Jr. from the Washington Commanders. B-Rob has been McCaffrey's backup through two weeks, relegating Guerendo to a distant RB3 role. In the Week 2 win over the New Orleans Saints, the 25-year-old didn't play a single snap on offense, with all 17 of his snaps coming on special teams. Guerendo averaged a healthy 5.0 yards per carry on 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) as a rookie in 2024 when CMC was bothered by injuries, but currently, he's well off the fantasy radar in single-year leagues going into Week 3 against the division-rival Arizona Cardinals.

From RotoBaller

Second-year running back Isaac Guerendo opens the season third on the 49ers' depth chart, though he may already see more action than originally anticipated. Christian McCaffrey (calf) popped up on the team's injury report this week and is tagged as questionable for San Francisco's Week 1 matchup against the Seahawks. Guerendo's only route to fantasy relevance relies on CMC sitting. If that does happen, then he can be seen as a deep-league flex candidate. Brian Robinson Jr. will likely draw the start, but Guerendo made his mark in 2024 in similar circumstances and is a potential RB4/5 pending McCaffrey's status.

From RotoBaller

San Francisco 49ers running back Isaac Guerendo (shoulder) played at less than 100 percent during Saturday's preseason contest. Guerendo started the game, but re-aggravated his shoulder injury in the first quarter. Luckily, Guerendo was able to return to the game after getting looked at on the sideline. At the moment, all signs point to Guerendo being available for the season opener. However, his fantasy value is going to take a serious hit with Brian Robinson Jr. taking over as the RB2 in San Francisco. Guerendo probably won't see significant snaps unless someone gets hurt in the backfield.

From RotoBaller

Dynasty | The trade of Brian Robinson to the 49ers creates an uncertain backfield in San Francisco. Dynasty Analysis: If there's a loser in the Robinson deal, it's probably Guerendo. He would likely split time with Robinson should Christian McCaffrey be injured but this deal makes it abundantly clear San Francisco is concerned about his injury history and not willing to leave themselves vulnerable should CMC go down. Guerendo has been a solid handcuff to own over the past two seasons but even if he was to remain the RB2, it's hard to see a situation where Robinson doesn't still split time with him. His dynasty ADP is going to slip over the next month.

Running back Christian McCaffrey is the San Francisco 49ers' unquestioned No. 1 RB when he's healthy, but Cam Inman of the Bay Area News Group thinks that Isaac Guerendo is still the projected RB2 behind CMC despite Friday's trade acquisition of Brian Robinson Jr, presuming that B-Rob isn't fast-tracked over the next two weeks. Guerendo resumed practicing this week after two weeks off from a shoulder dislocation, so he should be ready for Week 1 of the regular season against the division-rival Seattle Seahawks on Sunday, Sept. 7. Although the 25-year-old Guerendo figures to be the RB2 to open the year, it's entirely possible that Robinson leaps him on the RB depth chart eventually. The trade for B-Rob definitely is a hit to Guerendo's potential upside if CMC gets hurt again, too. Early on, Robinson will most likely be more of a short-yardage/goal-line power back in his new home.

From RotoBaller

San Francisco 49ers running back Isaac Guerendo (shoulder) returned to training camp practice on Tuesday and was pretty active, according to Matt Maiocco of NBC Sports Bay Area. Guerendo will have more opportunities for reps with both Patrick Taylor Jr. (shoulder) and Corey Kiner (ankle) both injured. The 25-year-old missed a couple of weeks at camp with a shoulder injury but is now back in time to be ready for the Week 1 regular-season opener in two weeks. It remains to be seen if the Niners will play him in the preseason finale against the Los Angeles Chargers on Saturday. Guerendo, a fourth-rounder last year, had a healthy 5.0 yards per carry and 420 rushing yards on 84 carries in 16 games (three starts) in his first season in the NFL. He's primarily a handcuff option for the injury-prone Christian McCaffrey, but if CMC misses more time with injury, Guerendo would be an every-week fantasy starter.

From RotoBaller

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From FantasyLife

Training Camp Injuries Impacting Fantasy Football: A.J. Brown, Isaac Guerendo, And More In today's Fantasy Life Newsletter, presented by Guillotine Leagues, five training camp injuries to monitor, Drafting from 1.06, and Tight End Tiers. [Read More]

From FantasyLife

Training Camp Injuries Impacting Fantasy Football: A.J. Brown, Isaac Guerendo, And More In today's Fantasy Life Newsletter, presented by Guillotine Leagues, five training camp injuries to monitor, Drafting from 1.06, and Tight End Tiers. [Read More]

From FantasyLife

Training Camp Injuries Impacting Fantasy Football: A.J. Brown, Isaac Guerendo, And More In today's Fantasy Life Newsletter, presented by Guillotine Leagues, five training camp injuries to monitor, Drafting from 1.06, and Tight End Tiers. [Read More]

From FantasyLife

San Francisco 49ers running back Isaac Guerendo (shoulder) is expected to miss a couple of weeks, according to Matt Maiocco of NBC Sports. Guerendo will miss time after getting injured during Saturday's training camp practice. While the 25-year-old still has time to get ready for the start of the regular season, he will miss important reps during practice and the preseason as he gets ready to serve as Christian McCaffrey's primary backup in 2025. With Guerendo now out for a few weeks, it will give rookie Jordan James more opportunities to run with the first-team offense when CMC needs a breather. In addition to James, Patrick Taylor Jr. and Ameer Abdullah should see more work in practices. When healthy, Guerendo's raw athletic abilities make him an intriguing handcuff if you take the leap on McCaffrey.

From RotoBaller

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From FantasyLife

San Francisco 49ers fullback Kyle Juszczyk (undisclosed) and running back Isaac Guerendo (shoulder/arm) both left the team's Saturday practice early, according to ESPN's Nick Wagoner. Wagoner writes that Juszczyk was "moving slowly." The 34-year-old is a key piece as a blocker and a receiver in the 49ers' offense, having racked up 2,901 yards from scrimmage over the course of his 12-year career. Juszczyk is uniquely versatile as a player, so there's not a clear replacement for him on San Francisco's roster if he were to miss time. Guerendo is expected to be the primary backup to star 49ers running back Christian McCaffrey. In 16 games as a rookie in 2024, Guerendo recorded 84 carries for 420 yards and four touchdowns. It's unclear how much time (if any) Guerendo will miss, but he now joins fifth-round rookie Jordan James (knee) as 49ers backs dealing with injuries. The team signed veteran rusher Ameer Abdullah on Thursday to bolster its depth at the position. If healthy, Guerendo is a premium handcuff option for fantasy.

From RotoBaller

San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.

From RotoBaller