Guest of the League
Lineup Changes
Akron Pros - Asa Knarian
| Benched | QB | Trevor Lawrence JAX | Owner | Sun Nov 10 12:30pm ET |
| Started | QB | Joe Flacco IND | Owner | Sun Nov 10 12:30pm ET |
| Started | TE | Pat Freiermuth PIT | Owner | Thu Nov 7 1:33pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 6 11:54pm ET |
| Started | RB | Jordan Mason SF | Owner | Wed Nov 6 11:54pm ET |
Buffalo All-Americans - AJ Klein
| Benched | WR | Michael Pittman Jr. IND | Owner | Sun Nov 10 8:58am ET |
| Started | WR | Sterling Shepard TB | Owner | Sun Nov 10 8:58am ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Thu Nov 7 5:00pm ET |
| Started | TE | Mike Gesicki CIN | Owner | Thu Nov 7 5:00pm ET |
| Benched | WR | Jakobi Meyers LV | Owner | Thu Nov 7 6:07am ET |
| Started | WR | Jameson Williams DET | Owner | Thu Nov 7 6:07am ET |
Chicago Cardinals - Jose Turnes
| Benched | D/ST | Seattle Seahawks SEA | Owner | Thu Nov 7 7:49pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 7 7:49pm ET |
Columbus Panhandles - Jughead
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 7 4:53pm ET |
| Started | K | Jake Moody SF | Owner | Thu Nov 7 5:53am ET |
| Benched | RB | Nick Chubb CLE | Owner | Tue Nov 5 7:32am ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 5 7:32am ET |
| Started | RB | Christian McCaffrey SF | Owner | Tue Nov 5 7:32am ET |
| Started | WR | Nico Collins HOU | Owner | Tue Nov 5 7:32am ET |
Dayton Triangles - Doc Emery
| Started | D/ST | Philadelphia Eagles PHI | Owner | Sun Nov 10 12:42pm ET |
| Started | K | Jake Elliott PHI | Owner | Thu Nov 7 6:02am ET |
Decatur Staleys - Steve Schwenk
| Benched | TE | Cole Kmet CHI | Owner | Thu Nov 7 6:57pm ET |
| Started | WR | Rashod Bateman BAL | Owner | Thu Nov 7 6:57pm ET |
| Benched | RB | Zack Moss CIN | Owner | Tue Nov 5 6:46pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 5 6:46pm ET |
| Started | WR | Deebo Samuel SF | Owner | Tue Nov 5 6:46pm ET |
| Started | TE | George Kittle SF | Owner | Tue Nov 5 6:46pm ET |
Detroit Heralds - Scott Byrne
| Started | QB | Russell Wilson PIT | Owner | Thu Nov 7 6:24am ET |
Duluth Eskimoes - Mitchell Byrne
| Benched | TE | Brock Bowers LV | Owner | Thu Nov 7 4:21pm ET |
| Started | TE | Will Dissly LAC | Owner | Thu Nov 7 4:21pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 6 1:31pm ET |
| Started | RB | Tank Bigsby JAX | Owner | Wed Nov 6 1:31pm ET |
Frankford Yellowjackets - Jason Keintz
| Started | D/ST | Kansas City Chiefs KC | Owner | Sun Nov 10 12:58pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 7 9:59am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 5 11:09am ET |
| Started | WR | Xavier Legette CAR | Owner | Tue Nov 5 11:09am ET |
Louisville Colonels - Alec Martinez
| Benched | RB | Alexander Mattison LV | Owner | Thu Nov 7 3:37pm ET |
| Started | RB | Khalil Herbert CIN | Owner | Thu Nov 7 3:37pm ET |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 7 6:35am ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 7 6:35am ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 7 6:35am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Nov 7 6:35am ET |
Massillon Tigers - Jeff O'Bryan
| Started | TE | Jonnu Smith MIA | Owner | Thu Nov 7 8:33am ET |
| Benched | RB | Antonio Gibson NE | Owner | Thu Nov 7 8:29am ET |
| Started | RB | Jonathon Brooks CAR | Owner | Thu Nov 7 8:29am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 7 8:29am ET |
Muncie Flyers - Troy Dean
| No starting lineup changes performed this week. |
Providence Steamroller - Patrick Hillary
| Benched | WR | Darius Slayton NYG | Owner | Thu Nov 7 9:48am ET |
| Started | WR | Demario Douglas NE | Owner | Thu Nov 7 9:48am ET |
| Started | K | Cairo Santos CHI | Owner | Thu Nov 7 9:46am ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Nov 5 12:26pm ET |
| Started | WR | George Pickens PIT | Owner | Tue Nov 5 12:26pm ET |
Rochestor Jeffersons -
| Started | K | Jake Bates DET | Owner | Sun Nov 10 10:26am ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 6 8:50am ET |
| Benched | WR | Tyler Lockett SEA | Owner | Wed Nov 6 8:50am ET |
| Started | RB | Najee Harris PIT | Owner | Wed Nov 6 8:50am ET |
| Started | WR | Jauan Jennings SF | Owner | Wed Nov 6 8:50am ET |
Rock Island Independents - Tim Wawrzyniak
| Benched | WR | Chris Olave NO | Owner | Fri Nov 8 11:47pm ET |
| Started | WR | Demarcus Robinson LAR | Owner | Fri Nov 8 11:47pm ET |
| Benched | RB | D'Onta Foreman CLE | Owner | Tue Nov 5 9:05pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 5 9:05pm ET |
Toledo Maroons - Evan Byrne
| Benched | WR | Jayden Reed GB | Owner | Fri Nov 8 8:44am ET |
| Started | WR | Gabriel Davis JAX | Owner | Fri Nov 8 8:44am ET |
