

| Benched | RB | Bucky Irving TB | Owner | Thu Nov 6 11:46am CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Thu Nov 6 11:46am CT |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 3:13pm CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 4 3:13pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 3:13pm CT |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 3:13pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 3:32pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 4 3:32pm CT |
| Started | WR | Chris Olave NO | Owner | Tue Nov 4 3:32pm CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 3:31pm CT |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 4 3:31pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 4 3:31pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 8:53am CT |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 4 8:53am CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 8:53am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 8:53am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 8:53am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 8:53am CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 8:53am CT |
| Started | TE | Cade Otton TB | Owner | Tue Nov 4 8:53am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 4 7:08pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 7:08pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 7:08pm CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 4 7:08pm CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 7:08pm CT |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 7:08pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | C.J. Stroud HOU | Owner | Tue Nov 4 10:04pm CT |
| Started | QB | Bryce Young CAR | Owner | Tue Nov 4 10:04pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 6 1:55am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 6 1:55am CT |
| Started | K | Eddy Pineiro SF | Owner | Thu Nov 6 1:55am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 4 7:53pm CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 7:53pm CT |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 7:53pm CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 7:53pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 7:53pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 6 5:23pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Thu Nov 6 5:23pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Thu Nov 6 5:23pm CT |
| Benched | TE | Tucker Kraft GB | Owner | Thu Nov 6 5:23pm CT |
| Started | QB | J.J. McCarthy MIN | Owner | Thu Nov 6 5:23pm CT |
| Started | RB | Kyle Monangai CHI | Owner | Thu Nov 6 5:23pm CT |
| Started | WR | Alec Pierce IND | Owner | Thu Nov 6 5:23pm CT |
| Started | TE | Colston Loveland CHI | Owner | Thu Nov 6 5:23pm CT |
| Started | WR | Stefon Diggs NE | Owner | Wed Nov 5 1:33pm CT |
| Benched | WR | Keenan Allen LAC | Owner | Wed Nov 5 1:33pm CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 4 1:05pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 4 1:05pm CT |
| Started | RB | David Montgomery DET | Owner | Tue Nov 4 1:05pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 1:05pm CT |
| Benched | D/ST | New England Patriots NE | Owner | Tue Nov 4 1:05pm CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 1:05pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 1:05pm CT |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 4 1:05pm CT |
| No starting lineup changes performed this week. |