
| Started | K | Ryan Fitzgerald CAR | Owner | Wed Nov 12 4:02am CT |
| Benched | TE | Oronde Gadsden II LAC | Owner | Wed Nov 12 2:12am CT |
| Benched | K | Ryan Fitzgerald CAR | Owner | Wed Nov 12 2:12am CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 12 2:12am CT |
| Benched | RB | Jonathan Taylor IND | Owner | Wed Nov 12 5:33pm CT |
| Benched | WR | Chris Olave NO | Owner | Wed Nov 12 5:33pm CT |
| Started | RB | Kyle Monangai CHI | Owner | Wed Nov 12 5:33pm CT |
| Started | WR | Rashid Shaheed SEA | Owner | Wed Nov 12 5:33pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Wed Nov 12 8:31am CT |
| Benched | K | Wil Lutz DEN | Owner | Wed Nov 12 8:31am CT |
| Started | TE | Dalton Schultz HOU | Owner | Wed Nov 12 8:31am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 12 8:31am CT |
| Benched | QB | Tua Tagovailoa MIA | Owner | Wed Nov 12 8:30am CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Wed Nov 12 8:30am CT |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 12 8:30am CT |
| Started | D/ST | Green Bay Packers GB | Owner | Wed Nov 12 8:30am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 11 8:20pm CT |
| Benched | RB | J.K. Dobbins DEN | Owner | Tue Nov 11 8:20pm CT |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Nov 11 8:20pm CT |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 11 8:20pm CT |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 11 8:20pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 11 8:50pm CT |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 11 8:50pm CT |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 12 9:39am CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 12 9:39am CT |
| Started | QB | J.J. McCarthy MIN | Owner | Wed Nov 12 9:39am CT |
| Started | TE | Dallas Goedert PHI | Owner | Wed Nov 12 9:39am CT |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 12 10:12am CT |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 12 10:12am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 12 9:54am CT |
| Benched | WR | Garrett Wilson NYJ | Owner | Wed Nov 12 9:54am CT |
| Started | RB | Chase Brown CIN | Owner | Wed Nov 12 9:54am CT |
| Started | WR | George Pickens DAL | Owner | Wed Nov 12 9:54am CT |
| Benched | TE | Dalton Kincaid BUF | Owner | Tue Nov 11 4:05pm CT |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 11 4:05pm CT |
| No starting lineup changes performed this week. |
| Benched | TE | AJ Barner SEA | Owner | Wed Nov 12 2:12pm CT |
| Started | RB | Aaron Jones MIN | Owner | Wed Nov 12 2:12pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 11 6:05am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 11 6:05am CT |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 11 6:05am CT |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 11 6:05am CT |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 11 6:05am CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 11 6:05am CT |