Guest of the League
Lineup Changes
49ers - Jean-Philippe Prud'homme
| Started | WR | Alec Pierce IND | Owner | Wed Sep 18 5:17am ET |
| Benched | WR | Keon Coleman BUF | Owner | Wed Sep 18 5:17am ET |
| Started | DB | Jalen Ramsey MIA | Owner | Tue Sep 17 11:27am ET |
| Started | DB | Quinyon Mitchell PHI | Owner | Tue Sep 17 11:27am ET |
| Started | LB | Travon Walker JAX | Owner | Tue Sep 17 11:27am ET |
| Started | WR | Adam Thielen CAR | Owner | Tue Sep 17 11:27am ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Sep 17 11:27am ET |
| Benched | DB | Derwin James LAC | Owner | Tue Sep 17 11:27am ET |
| Benched | DB | Chauncey Gardner-Johnson PHI | Owner | Tue Sep 17 11:27am ET |
| Benched | LB | Khalil Mack LAC | Owner | Tue Sep 17 11:27am ET |
| Benched | WR | Deebo Samuel SF | Owner | Tue Sep 17 11:27am ET |
| Benched | WR | Cooper Kupp LAR | Owner | Tue Sep 17 11:27am ET |
Browns - Mathieu Francoeur
| No starting lineup changes performed this week. |
Colts de Griffintown - Martin Thibault
| Benched | DB | Charvarius Ward SF | Owner | Fri Sep 20 3:47pm ET |
| Started | DB | Jeremy Chinn WAS | Owner | Fri Sep 20 3:47pm ET |
| Benched | QB | Matthew Stafford LAR | Owner | Wed Sep 18 11:48am ET |
| Started | QB | Gardner Minshew II LV | Owner | Wed Sep 18 11:48am ET |
Eagles - Sebastien Bertrand
| Benched | TE | George Kittle SF | Owner | Sat Sep 21 12:59am ET |
| Started | TE | Cole Kmet CHI | Owner | Sat Sep 21 12:59am ET |
| Benched | WR | Keenan Allen CHI | Owner | Fri Sep 20 2:55pm ET |
| Started | WR | Tee Higgins CIN | Owner | Fri Sep 20 2:55pm ET |
| Benched | RB | Joe Mixon HOU | Owner | Thu Sep 19 12:31pm ET |
| Started | RB | Zack Moss CIN | Owner | Thu Sep 19 12:31pm ET |
GMen - Francis Coderre
| Benched | LB | Lavonte David TB | Owner | Tue Sep 17 9:13pm ET |
| Started | LB | Quay Walker GB | Owner | Tue Sep 17 9:13pm ET |
Lazy Bears - Alex Labrie
| Benched | WR | Terry McLaurin WAS | Owner | Thu Sep 19 11:54am ET |
| Started | WR | Amari Cooper CLE | Owner | Thu Sep 19 11:54am ET |
| Benched | DL | DeForest Buckner IND | Owner | Wed Sep 18 12:24pm ET |
| Started | DL | Kwity Paye IND | Owner | Wed Sep 18 12:24pm ET |
Packers - Alexandre Jette
| Benched | QB | Tua Tagovailoa MIA | Owner | Thu Sep 19 7:54am ET |
| Benched | WR | Christian Kirk JAX | Owner | Thu Sep 19 7:54am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Sep 19 7:54am ET |
| Started | QB | Jordan Love GB | Owner | Thu Sep 19 7:54am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Sep 19 7:54am ET |
| Started | TE | David Njoku CLE | Owner | Thu Sep 19 7:54am ET |
Panthers - Serge Savoie
| Benched | LB | Zaire Franklin IND | Owner | Wed Sep 18 6:50pm ET |
| Benched | DB | Kyle Hamilton BAL | Owner | Wed Sep 18 6:50pm ET |
| Started | LB | Alex Singleton DEN | Owner | Wed Sep 18 6:50pm ET |
| Started | DB | Deonte Banks NYG | Owner | Wed Sep 18 6:50pm ET |
| Benched | RB | Isiah Pacheco KC | Owner | Wed Sep 18 12:22pm ET |
| Started | RB | Aaron Jones MIN | Owner | Wed Sep 18 12:22pm ET |
Patriots de Rosemont - Jonathan Vallieres
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Sep 18 9:57am ET |
| Benched | LB | Terrel Bernard BUF | Owner | Wed Sep 18 9:57am ET |
| Started | WR | Tank Dell HOU | Owner | Wed Sep 18 9:57am ET |
| Started | LB | De'Vondre Campbell SF | Owner | Wed Sep 18 9:57am ET |
| Benched | WR | Brandon Aiyuk SF | Owner | Tue Sep 17 8:37am ET |
| Benched | TE | Evan Engram JAX | Owner | Tue Sep 17 8:37am ET |
| Started | WR | Jameson Williams DET | Owner | Tue Sep 17 8:37am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Sep 17 8:37am ET |
Seahawks - Martin Hawley
| Benched | LB | C.J. Mosley NYJ | Owner | Wed Sep 18 10:21pm ET |
| Started | LB | Azeez Al-Shaair HOU | Owner | Wed Sep 18 10:21pm ET |
