

| No starting lineup changes performed this week. |
| Started | D/ST | Seattle Seahawks SEA | Owner | Thu Oct 30 7:39am CT |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Oct 30 7:39am CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Thu Oct 30 7:38am CT |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Thu Oct 30 7:38am CT |
| Started | WR | Davante Adams LAR | Owner | Thu Oct 30 7:38am CT |
| Started | RB | Aaron Jones MIN | Owner | Thu Oct 30 7:38am CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Thu Oct 30 7:38am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Oct 30 7:38am CT |
| Benched | WR | Jordan Addison MIN | Owner | Thu Oct 30 7:38am CT |
| Benched | RB | Saquon Barkley PHI | Owner | Thu Oct 30 7:38am CT |
| Benched | WR | Rome Odunze CHI | Owner | Thu Oct 30 10:45am CT |
| Started | RB | Chase Brown CIN | Owner | Thu Oct 30 10:45am CT |
| Started | QB | Lamar Jackson BAL | Owner | Wed Oct 29 10:01am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Oct 29 10:01am CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Oct 30 4:07am CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Oct 30 4:07am CT |
| Benched | RB | Jordan Mason MIN | Owner | Thu Oct 30 4:03am CT |
| Started | RB | Kimani Vidal LAC | Owner | Thu Oct 30 4:03am CT |
| Benched | K | Will Reichard MIN | Owner | Tue Oct 28 5:34pm CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 5:34pm CT |
| Started | K | Jason Myers SEA | Owner | Tue Oct 28 5:34pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Wed Oct 29 4:34am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Oct 28 8:03pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Oct 28 8:03pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Oct 28 8:01pm CT |
| Benched | RB | J.K. Dobbins DEN | Owner | Tue Oct 28 8:01pm CT |
| Started | QB | Caleb Williams CHI | Owner | Tue Oct 28 8:01pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Oct 28 8:01pm CT |
| Benched | WR | Rashid Shaheed NO | Owner | Tue Oct 28 8:58am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 8:58am CT |
| No starting lineup changes performed this week. |
| Started | RB | Derrick Henry BAL | Owner | Wed Oct 29 7:22pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Wed Oct 29 7:22pm CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Oct 29 7:18pm CT |
| Benched | WR | Matthew Golden GB | Owner | Wed Oct 29 7:18pm CT |
| Started | K | Jake Bates DET | Owner | Wed Oct 29 7:18pm CT |
| Benched | K | Jake Elliott PHI | Owner | Wed Oct 29 7:18pm CT |
| Started | WR | Matthew Golden GB | Owner | Wed Oct 29 7:16pm CT |
| Benched | WR | Terry McLaurin WAS | Owner | Wed Oct 29 7:16pm CT |
| Started | RB | Kyren Williams LAR | Owner | Wed Oct 29 7:15pm CT |
| Started | RB | Tony Pollard TEN | Owner | Wed Oct 29 7:15pm CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Oct 29 7:15pm CT |
| Benched | RB | Derrick Henry BAL | Owner | Wed Oct 29 7:15pm CT |