Pittsburgh Steelers tight end Pat Freiermuth returned to the end zone last week and will hope for similar success in Week 13 against the Buffalo Bills. Unfortunately, he draws the toughest possible matchup. Buffalo has held opposing tight ends to the fewest fantasy points, receptions, yards, and touchdowns this season. While Freiermuth has been more productive than teammate Jonnu Smith, none of Pittsburgh's tight ends are commanding consistent weekly opportunities. Between Freiermuth, Smith, and Darnell Washington, Freiermuth's red-zone usage suggests he is the most likely to score on Sunday, but fantasy managers should steer clear of this matchup if possible.

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Buffalo Bills wide receiver Joshua Palmer hauled in two of four targets for 21 yards in Week 12's 23-19 loss to the Houston Texans. Palmer has been quiet in his first season in Buffalo, as he's currently averaging his fewest fantasy points per game of his entire five-year career. Palmer is a part of one of the worst receiving units in the NFL and has been unable to stand out as a top option in this offense. Maybe this is the week, as the Bills face the league's worst defense against wide receivers this season in the Pittsburgh Steelers. While Palmer may be a cheap and tempting DFS option in Week 13, fantasy managers should steer clear of starting the veteran receiver this week.

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Indianapolis Colts rookie tight end Tyler Warren (illness) was added to the injury report and is now questionable to play in Week 13 against the Houston Texans. The rookie tight end has been a budding superstar in 2025, hauling in 55 of 74 passes for 662 yards and three touchdowns in 11 games. Warren is currently on pace to finish as the TE3 in fantasy points per game and has been a huge part of the Colts' offensive explosion in 2025. If Warren is unable to play in Week 13, it would be a massive blow to this attack, especially against the league's best defense. Fantasy managers will have to check into the pregame reports to see if he's active and if his role will be limited in Week 13.

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Pittsburgh Steelers wide receiver DK Metcalf (ankle) is off the injury report and ready to go for a Week 13 showdown with the Buffalo Bills. Although Metcalf found the end zone last week, he hasn't topped 50 receiving yards in a game since Week 8 and has become increasingly unreliable for fantasy purposes. The Bills have been strong against the pass, surrendering the 10th-fewest receptions and the 10th-fewest receiving yards to opposing wideouts this season. Even with quarterback Aaron Rodgers (wrist) in line to start, Metcalf cannot be projected for a ceiling outcome in this matchup. Fantasy managers can still deploy him as a high-end WR3 or flex option, but expectations for Metcalf should be tempered.

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Buffalo Bills wide receiver Khalil Shakir had a big-time performance in Week 12, hauling in eight of 10 targets for 110 yards against the Houston Texans. His huge outing was his first 10+ target and 100+ yard game of the season. Shakir is averaging 11.5 PPR fantasy points per game, leading the way in Buffalo as the number one option in the passing game. He faces the Pittsburgh Steelers in Week 13, who have allowed the most fantasy points to wide receivers this season. The Steelers have also allowed the seventh most fantasy points per game to slot receivers this season, which is where Shakir likes to operate. After being an inconsistent option for fantasy managers at the beginning of the season, Shakir is a WR3/FLEX play in Week 13.

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Pittsburgh Steelers quarterback Aaron Rodgers (wrist) missed last week's contest but is set to return at home against the Buffalo Bills. While Buffalo has been vulnerable on the ground, its pass defense has been elite, limiting opposing quarterbacks to the fewest passing yards, the fourth-fewest passing touchdowns, and the fourth-fewest fantasy points per game. Unless the Steelers find themselves trailing early, they're likely to lean heavily on the running game with Jaylen Warren and Kenneth Gainwell. This makes Rodgers tough to trust for fantasy purposes, especially if he is limited at all with his left wrist fracture. Fantasy managers should view Rodgers as a low-end QB2 who is only viable in 2QB and superflex formats in Week 13.

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Buffalo Bills running back James Cook has been on a terror in his fourth season in the NFL, totaling 1287 scrimmage yards and nine touchdowns in 11 games. Despite the Bills struggling against the Houston Texans in Week 12, Cook had a big game, totaling 129 yards and a touchdown on 20 attempts. Cook has ascended in every season he's been in the NFL, jumping from a 16.7 PPR points per game average in 2024 to an 18.7 average this season. While Cook has been matchup-proof this season, the Steelers are very tough against the run, allowing the sixth fewest fantasy points to running backs this season. Despite the difficult matchup, Cook is a sure-fire RB1 in fantasy this week, as he looks to continue his dominance.

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Jacksonville Jaguars running back Bhayshul Tuten has had mixed involvement in the Jaguars rushing attack, but this week against the 1-10 Titans seems like an ideal week to get him involved. In what should be a straight-forward win, the Jaguars have a chance to get their electric rookie more involved than usual. The game scrip should also favor the running game, and the Titans have a weak rushing defense. It is a risk to start Tuten considering he is coming off a rough seven carry for 17 yards performance against the Arizona Cardinals, but that involvement is still promising enough to have faith in a bounce-back week. Anyone looking for a high-risk high-reward flex in Week 13 should be intrigued by Tuten against the Titans.

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Buffalo Bills quarterback Josh Allen is coming off his worst game of the 2025 season, completing 24 of 34 passes for 253 yards and throwing two interceptions against the NFL's top defense. It's been a rollercoaster of a season for the reigning MVP, who's still averaging 23.2 fantasy points per game but has been much more inconsistent than in previous seasons. Allen will head to Pittsburgh to face the Steelers in Week 13, in what should be a playoff-like atmosphere. The Steelers' defense has allowed the fifth-most fantasy points to quarterbacks this season, including big outings for Caleb Williams, Joe Flacco, and Jordan Love. Allen enters Week 13 looking to bounce back and could be in line for a big game. Per usual, the Bills' star quarterback is a must-start in fantasy this week.

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Las Vegas Raiders wide receiver Tyler Lockett is coming off his best performance of the season in Week 12 against the Cleveland Browns, recording four catches for 62 yards on five targets. The veteran has been a reliable pass-catching option over the past three games, leading the Raiders' wide receivers with 12 catches (14 targets) for 139 yards, averaging 8.6 PPR points per game. It will be interesting to see how the Las Vegas offense looks in Week 13 against the Los Angeles Chargers after the dismissal of offensive coordinator Chip Kelly earlier this week. It's a tough matchup on Sunday for Lockett, with the Chargers allowing the second-fewest PPR points per game to opposing wideouts.

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Jacksonville Jaguars wide receiver Jakobi Meyers has been solid since being acquired by the Jaguars back in Week 10. He's always been a reliable short-field option, making him useful in PPR leagues, but he found the endzone last week to help him produce a good fantasy outing. Over the last two games, he has nine receptions on 12 targets for 114 yards and a touchdown. However, with Brian Thomas Jr. returning from injury, it is unclear what Meyers's role will be moving forward. Considering Thomas Jr. is more of a deep threat, there's a possibility it won't change that much. That makes Meyers a solid flex play with limited upside against a weak Titans defense. Especially in PPR leagues, Meyers is a fine play in Week 13.

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Las Vegas Raiders running back Raheem Mostert has served as the primary backup to rookie Ashton Jeanty this season, totaling 20 carries for 92 yards, along with nine receptions (nine targets) for 63 yards in eight games. The veteran hasn't recorded more than four touches in a game since Week 6 against the Tennessee Titans. Mostert would be in line to handle the bulk of the touches for the Raiders if Jeanty were to miss any time, but he remains off fantasy radars for Week 13 against the Los Angeles Chargers.

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Pittsburgh Steelers running back Kenneth Gainwell has been on a hot streak lately and will look to carry that momentum into a Week 13 meeting with the Buffalo Bills. The Bills have struggled to stop the run this season, allowing the third-most fantasy points and second-most yards per attempt to opposing running backs. However, they haven't allowed much receiving production to the position, which is noteworthy given Gainwell's significant role as a pass-catcher. Still, he should approach double-digit carries in this one, even with Jaylen Warren playing ahead of him on early downs. Gainwell isn't quite a must-start fantasy option, but with Aaron Rodgers (wrist) back under center, Pittsburgh should keep Sunday's contest competitive enough for him to provide value as a high-end flex play.

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Cleveland Browns wide receiver Jerry Jeudy had just one catch for 39 yards on three targets in last week's win over the Las Vegas Raiders. Jeudy wasn't very involved in Shedeur Sanders' first career start, and to make matters worse, he lost a fumble on his only reception. The 26-year-old is tied for the lead league with nine drops this season and hasn't been a reliable fantasy producer in a poor Browns offense. Jeudy will look for better production on Sunday against a San Francisco 49ers defense that has allowed the 12th most PPR points per game to opposing wide receivers this season. He ranks as RotoBaller's WR56 in PPR leagues for Week 13.

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Jacksonville Jaguars running back Travis Etienne Jr. should be in line for a good fantasy day against the Tennessee Titans in Week 13. Not only should game script favor the Jaguars running game against their 1-10 division rival, but the Titans defense has been extra susceptible to the run compared to the pass. That means the Jaguars game plan on paper should be to run early and often, meaning if Etienne Jr. can find the end zone, he could have a big day. Bhayshul Tuten has had mixed involvement in the rushing attack which could limit Etienne Jr.'s upside slightly, but that shouldn't deter fantasy managers. Start the Jaguars star back with confidence in Week 13.

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Pittsburgh Steelers running back Jaylen Warren had a solid game last week and will look to build on that performance against the Buffalo Bills in Week 13. Buffalo has been solid against the pass but extremely vulnerable on the ground, surrendering the third-most rushing yards, the second-most yards per carry, and the third-most fantasy points to opposing running backs. Warren will continue to split work with Kenneth Gainwell, who has emerged as Pittsburgh's preferred receiving back. Still, Warren remains the clear leader on the ground. The 27-year-old has logged double-digit carries in every game he's played this season, while Gainwell has reached 10 carries just twice. Though the Steelers enter this matchup as underdogs, they are projected to keep it competitive at home, suggesting plenty of utilization for Warren throughout. Fantasy managers should treat Warren as a high-end RB2 with upside on Sunday.

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Jacksonville Jaguars wide receiver Brian Thomas Jr. (ankle) was a full participant at practice on Thursday and Friday and seems well recovered from the injury that held him out for three games. That doesn't necessarily mean he is in line for big game, however, as he hasn't been the most consistent fantasy option this season. The receiver room is also filled with competition still after the Jaguars traded for Jakobi Meyers to replace the injured Travis Hunter, and tight end Brenton Strange returned from injury. The Titans defense is very vulnerable, but game script should favor the rushing attack more. If Thomas Jr. can get involved early, he could have a good fantasy day, but that is a huge if in a huge Week 13 fantasy week.

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Las Vegas Raiders tight end Brock Bowers recorded six catches for 55 yards on nine targets last week's loss to the Cleveland Browns. It was a quiet day for the star tight end who salvaged his day with four catches for 35 yards on the Raiders' final two drives in ultimate garbage time, with the game's outcome already decided. Bowers will look to bounce back in a major way in Week 13 against the Los Angeles Chargers, where the Raiders offense could look a bit different after the team dismissed offensive coordinator Chip Kelly. Bowers recorded five catches for 38 yards on eight targets in their Week 2 meeting when he was banged up with a knee injury. The second-year tight ranks as a top-two option again in Week 13 and should be locked into all fantasy lineups.

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Jacksonville Jaguars quarterback Trevor Lawrence doesn't seem to have much upside heading into a Week 13 matchup with the Tennessee Titans. The division rival has the worst record in football, likely meaning a run-heavy game for the Jacksonville offense. That means unless Lawrence can get touchdowns early, then it's hard to see him having a great fantasy day. He should do solid, but the combination of a likely great defensive outing producing points and good field position along with a potentially run heavy game plan limits Lawrence's upside greatly. He remains firmly a QB2 in Week 13.

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Las Vegas Raiders wide receiver Tre Tucker is coming off seeing a career high of 10 targets in Week 12 against the Cleveland Browns. Tucker recorded just three receptions for 28 yards, but the volume of targets was positive to see. The 24-year-old was listed on the injury report this week due to a knee injury, but practiced in full on Thursday and Friday and heads into Sunday without an injury designation. The Las Vegas offense could look different in Week 13 against the Los Angeles Chargers after the firing of offensive coordinator Chip Kelly earlier in the week. Tucker is still a risky fantasy option in 12-team leagues against a Chargers defense that has allowed the second-fewest PPR points per game to opposing wide receivers.

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