| Player | Pos | DChart | NFL | Bye | Inj | Wk13 | Pts | Avg | 3Avg | |
|---|---|---|---|---|---|---|---|---|---|---|
| 2. | Christian McCaffrey | RB | RB.1 | SF | 14 | @CLE | 311.10 | 25.93 | 26.63 | |
| 7. | Matthew Stafford | QB | QB.1 | LAR | 8 | @CAR | 258.10 | 23.46 | 23.38 | |
| 13. | Justin Herbert | QB | QB.1 | LAC | 12 | LV | 243.05 | 22.10 | 17.75 | |
| 22. | Puka Nacua | WR | RWR.1 | LAR | 8 | @CAR | 211.00 | 19.18 | 16.47 | |
| 28. | Davante Adams | WR | LWR.1 | LAR | 8 | @CAR | 183.10 | 16.65 | 16.67 | |
| 33. | Kyren Williams | RB | RB.1 | LAR | 8 | @CAR | 174.00 | 15.82 | 14.93 | |
| 34. | Aaron Rodgers | QB | QB.1 | PIT | 5 | BUF | 172.15 | 15.65 | 6.88 | |
| 36. | Lamar Jackson | QB | QB.1 | BAL | 7 | CIN | 167.45 | 15.22 | 11.93 | |
| 44. | Derrick Henry | RB | RB.1 | BAL | 7 | CIN | 161.90 | 14.72 | 18.13 | |
| 51. | Justin Jefferson | WR | LWR.1 | MIN | 6 | @SEA | 151.90 | 13.81 | 9.20 | |
| 60. | Mac Jones | QB | QB.2 | SF | 14 | @CLE | 160.05 | 13.34 | 9.08 | |
| 64. | Zay Flowers | WR | SWR.1 | BAL | 7 | CIN | 143.30 | 13.03 | 11.77 | |
| 67. | Ladd McConkey | WR | SWR.1 | LAC | 12 | LV | 142.40 | 12.95 | 11.53 | |
| 71. | Keenan Allen | WR | RWR.1 | LAC | 12 | LV | 139.20 | 12.65 | 6.43 | |
| 72. | D.K. Metcalf | WR | LWR.1 | PIT | 5 | BUF | 136.50 | 12.41 | 10.27 | |
| 77. | Jaylen Warren | RB | RB.1 | PIT | 5 | BUF | 131.50 | 11.95 | 10.87 | |
| 80. | Kenneth Gainwell | RB | RB.2 | PIT | 5 | BUF | 128.10 | 11.65 | 16.70 | |
| 86. | Quentin Johnston | WR | LWR.1 | LAC | 12 | LV | 123.10 | 11.19 | 8.17 | |
| 88. | Cameron Dicker | K | LAC | 12 | LV | 120.70 | 10.97 | 11.73 | ||
| 98. | Chris Boswell | K | PIT | 5 | BUF | 116.80 | 10.62 | 6.97 | ||
| 109. | Will Reichard | K | MIN | 6 | @SEA | 108.80 | 9.89 | 8.80 | ||
| 116. | Tyler Loop | K | BAL | 7 | CIN | 106.70 | 9.70 | 12.80 | ||
| 120. | Eddy Pineiro | K | SF | 14 | O | @CLE | 112.60 | 9.38 | 6.07 | |
| 127. | Mark Andrews | TE | TE.1 | BAL | 7 | CIN | 102.00 | 9.27 | 9.40 | |
| 134. | Oronde Gadsden II | TE | TE.1 | LAC | 12 | LV | 98.70 | 8.97 | 7.40 | |
| 135. | Jordan Mason | RB | RB.2 | MIN | 6 | @SEA | 98.50 | 8.95 | 6.27 | |
| 142. | Pittsburgh Steelers | D/ST | DEF | PIT | 5 | BUF | 96.00 | 8.73 | 11.33 | |
| 144. | Jauan Jennings | WR | SWR.1 | SF | 14 | @CLE | 103.90 | 8.66 | 14.20 | |
| 155. | Jordan Addison | WR | RWR.1 | MIN | 6 | @SEA | 88.80 | 8.07 | 5.50 | |
| 156. | Los Angeles Rams | D/ST | DEF | LAR | 8 | @CAR | 88.00 | 8.00 | 9.67 | |
| 158. | George Kittle | TE | TE.1 | SF | 14 | @CLE | 95.90 | 7.99 | 20.63 | |
| 161. | Carson Wentz | QB | MIN | 6 | X | @SEA | 87.50 | 7.95 | 0.00 | |
| 164. | J.J. McCarthy | QB | QB.1 | MIN | 6 | O | @SEA | 85.45 | 7.77 | 10.68 |
| 177. | Matt Gay | K | SF | 14 | @CLE | 87.10 | 7.26 | 7.37 | ||
| 178. | T.J. Hockenson | TE | TE.1 | MIN | 6 | @SEA | 79.90 | 7.26 | 5.20 | |
| 179. | Pat Freiermuth | TE | TE.1 | PIT | 5 | BUF | 79.80 | 7.25 | 6.70 | |
| 189. | Omarion Hampton | RB | KR.4 | LAC | 12 | X | LV | 77.00 | 7.00 | 0.00 |
| 190. | Kimani Vidal | RB | RB.1 | LAC | 12 | LV | 77.00 | 7.00 | 8.03 | |
| 207. | Brock Purdy | QB | QB.1 | SF | 14 | @CLE | 79.55 | 6.63 | 11.42 | |
| 209. | Kendrick Bourne | WR | RWR.2 | SF | 14 | @CLE | 79.20 | 6.60 | 0.97 | |
| 213. | Aaron Jones | RB | RB.1 | MIN | 6 | @SEA | 70.50 | 6.41 | 11.90 | |
| 222. | Jalen Nailor | WR | SWR.1 | MIN | 6 | @SEA | 67.30 | 6.12 | 8.67 | |
| 224. | Jake Tonges | TE | TE.2 | SF | 14 | @CLE | 72.60 | 6.05 | 0.00 | |
| 225. | Justice Hill | RB | RB.2 | BAL | 7 | X | CIN | 66.60 | 6.05 | 2.77 |
| 226. | Calvin Austin III | WR | SWR.1 | PIT | 5 | BUF | 65.80 | 5.98 | 4.17 | |
| 241. | Jonnu Smith | TE | TE.2 | PIT | 5 | BUF | 61.10 | 5.55 | 2.40 | |
| 245. | Los Angeles Chargers | D/ST | DEF | LAC | 12 | LV | 60.00 | 5.45 | 6.00 | |
| 247. | Minnesota Vikings | D/ST | DEF | MIN | 6 | @SEA | 58.00 | 5.27 | 1.33 |