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Players: Emmanuel Sanders, Marquise Goodwin, Jimmy Garoppolo, George Kittle, Dante Pettis, Andy Isabella, Kyler Murray

San Francisco 49ers quarterback Jimmy Garoppolo (10) passes against Seattle Seahawks defensive tackle Quinton Jefferson (99) during the second half of an NFL football game in Santa Clara, Calif., Monday, Nov. 11, 2019. (AP Photo/Tony Avelar)


Arizona Cardinals quarterback Kyler Murray (1) throws a pass against the Tampa Bay Buccaneers during the first half of an NFL football game Sunday, Nov. 10, 2019, in Tampa, Fla. (AP Photo/Jason Behnken)


SANTA CLARA, Calif. (AP) After nothing but success the first eight games of the season, the San Francisco 49ers now are learning to deal with failure.

The Niners' perfect season was derailed last week with an overtime loss to the Seattle Seahawks when San Francisco was unable to overcome a litany of offensive miscues.

The 49ers (8-1) will look to get back on the winning track Sunday when they host the Arizona Cardinals (3-6-1) for the second time in three weeks.

''I think we have a good mindset with it,'' said quarterback Jimmy Garoppolo, who had his worst day of the season in the 27-24 loss. ''Everyone was in here yesterday working on the day off. Today it's just a sense of urgency in the building. It's good to see that.''

San Francisco committed three turnovers, allowed five sacks and struggled to get much of anything going consistently on the ground or through the air against Seattle.

The 49ers had season lows in yards rushing (87) and yards per attempt passing (4.7) on a night that star tight end George Kittle was out with an injury and No. 1 receiver Emmanuel Sanders left with injured ribs in the first quarter.

San Francisco is using that performance as a teaching tool for the rest of the season.

''You learn from the good and you learn more from the bad,'' tackle Mike McGlinchey said. ''It's a huge step in the right direction for us to be able take as many blows as we did and play as poorly as we did and still have a chance, not only one chance but multiple chances to win that game. That's a testament to how our defense played. ... We need to do a better job on the offensive side of the ball to make sure we reward their work.''

The Cardinals are stumbling toward their bye week, having lost three straight games after a promising start to the first season under coach Kliff Kingsbury and rookie quarterback Kyler Murray.

One of those losses was two weeks ago when Arizona fell 28-25 at home to the 49ers, a performance that gives the Cardinals confidence that if they can fix some mistakes they can compete with the first-place Niners.

''I don't think we played our best game,'' Murray said. ''I know personally, if we just go out and execute - they know what we do, we know what they do - if we go out and execute, we should be in good shape.''

MISSING TARGETS

The Niners' offense was done in by the absence of Kittle and Sanders last week. San Francisco scored 10 points on the opening two drives when Sanders was healthy and then just six more on offense the rest of the game. With no consistent receiving threats, the Seahawks were able to load up against the run and allow only 3.2 yards per carry. Kendrick Bourne had two key drops for San Francisco, while Dante Pettis and Marquise Goodwin combined for no catches on six targets.

ISABELLA ARRIVES

Arizona has relied on a variety of playmakers this season and the latest to make big plays is rookie receiver Andy Isabella. The second-round pick out of UMass had an 88-yard touchdown catch against the 49ers in the first meeting between the teams on Oct. 31. He has six catches for 174 yards over the past three games after not even being targeted in the season's first seven games. Kingsbury said Isabella has been improving steadily all season.

''It's been trending that way for a while,'' he said. ''We've had him inside, had him outside, and I think now the comfort level, having him outside more so, has really helped his development recently.''

MAN IN THE MIDDLE

The defensive star of the game for the 49ers last week was middle linebacker Fred Warner, who stepped up his performance in his first game since fellow starting linebacker Kwon Alexander suffered a season-ending torn pectoral muscle. Warner had 10 tackles, the first two sacks of his career, one forced fumble and a pass defensed.

''He gets us in and out of everything,'' coach Kyle Shanahan said. ''He has to make a ton of calls. He's definitely our quarterback out there and I think he does it as good as anyone I've seen.''

DEFENSIVE TROUBLES

Arizona's defense ranks 31st out of 32 teams in points allowed (281), total yards allowed per game (412.5) and passing yards allowed per game (286.5). The Cardinals have given up at least 21 points in all 10 games this season but never have given up more than 38. Linebacker Chandler Jones has been one of the bright spots with 11 1/2 sacks and five forced fumbles. Three-time All-Pro cornerback Patrick Peterson returned from a six-game suspension last month but hasn't had much of an impact. Kingsbury said the Cardinals had bouts of poor tackling in last week's 30-27 loss to Tampa Bay.

''There were some shoulders being thrown,'' Kingsbury said. ''We have to be better in those situations.''

BLIND SIDE

The 49ers again will be without starting left tackle Joe Staley, who will be out a couple of weeks after undergoing surgery on a broken finger. Staley broke a bone in his leg in Week 2 and missed the next six games. He then got hurt in his return to the lineup. With Staley unable to go, rookie Justin Skule is expected to move back into the lineup.

''I thought he did a very good job,'' Shanahan said of Skule. ''He came in there and stepped it up right away. Did a good job in his first game and I thought he got better each week.''

Player Notes
DeVante Parker Dec 14 10:40pm ET

Miami Dolphins wide receiver Devante Parker (concussion) has cleared the league's concussion protocol and will play on Sunday against the New York Giants. The Giants are starting four rookies in the secondary and Parker and the Dolphins shouldn't have too hard a time moving the ball. Parker is a strong WR2 with a nice ceiling for the fantasy semifinals this week. Parker's fellow Dolphins receiver Albert Wilson also cleared the protocol and will suit up for Sunday's game.

From RotoBaller

Saquon Barkley Dec 14 9:43pm ET

New York Giants RB Saquon Barkley said he is feeling 'healthier and healthier' ahead of a Week 15 matchup with a Miami Dolphins team ranked 31st in the NFL in rushing defense.

Fantasy Spin: Barkley hasn't had a 100-yard rushing game since Week 2, and he has gone five straight games without scoring. He has been one of the bigger fantasy disappointments this season, but RB2 numbers should be possible in Week 15 with a friendly matchup on tap.

From TheHuddle

Rashaad Penny Dec 14 9:23pm ET

Seattle Seahawks RB Rashaad Penny (knee) was placed on the Reserve/Injured list, Saturday, Dec. 14.

Fantasy Spin: The knee injury certainly won't help the former first-round pick establish himself as the potential starter in Seattle in 2020. If you own Penny in a dynasty league, you just have to stash him and hope he eventually turns things around.

From TheHuddle

Mecole Hardman Dec 14 9:10pm ET

Kansas City Chiefs wide receiver Mecole Hardman has seen his targets decrease since Tyreek Hill and Sammy Watkins returned healthy. He's seen one target over the last two games, but that catch was a 48-yard touchdown. Hardman doesn't see enough targets to warrant owning in most formats. He's a touchdown-dependent receiver that is only worth using in the deepest of leagues. It's unclear how he'll be worked into the game plan, so he's risky for fantasy formats.

From RotoBaller

Travis Kelce Dec 14 9:10pm ET

Kansas City Chiefs tight end Travis Kelce has been arguably the best tight end in the NFL alongside George Kittle. Kelce is expected to easily surpass 1,000 receiving yards on the season during the Week 15 matchup with the Denver Broncos. Kelce should be in for a solid game against the average Broncos Defense. Fantasy owners have been able to count on Kelce basically every week this season. He'll remain a TE1 for this home matchup with Denver.

From RotoBaller

Sammy Watkins Dec 14 9:00pm ET

Kansas City Chiefs wide receiver Sammy Watkins has been unable to live up to his epic Week 1 performance. He's been able to carry enough fantasy value worth rostering him in most 12-team leagues, but hasn't scored since Week 1. Watkins heads into a matchup against the Denver Broncos in Week 15. The Broncos Defense has allowed the sixth fewest fantasy points to wide receivers this season, according to Yahoo Sports. Fantasy owners should consider Watkins a WR3 or flex option for Sunday.

From RotoBaller

Darwin Thompson Dec 14 8:40pm ET

Kansas City Chiefs running back Darwin Thompson has seen increased involvement in the offense the last two games. Damien Williams (ribs) and Darrel Williams (hamstring) both being sidelined has given Thompson an opportunity in the backfield. Damien has a chance to play in Sunday's Week 15 contest against the Denver Broncos. Having him back might push Thompson out of the backfield rotation. Thompson showed promise in the passing game when he caught four passes for 36 yards versus the Patriots in Week 14. Thompson could again have value in the passing game if Williams is forced to sit out again. He's only a deep league option at this point, but he could have some flex value if Williams remains out.

From RotoBaller

Tyreek Hill Dec 14 8:40pm ET

Kansas City Chiefs wide receiver Tyreek Hill has been a reliable fantasy option throughout most of the season. However, Hill has been unable to find the end zone through the last three games. He's heading into a matchup with the Denver Broncos in Week 15. The same team that he caught three passes for 74 yards and a touchdown on in Week 7. Fantasy owners should feel confident that Hill can be a WR1 for this home matchup with Denver. Hill has caught at least five receptions in each of the last two games.

From RotoBaller

LeSean McCoy Dec 14 8:30pm ET

Kansas City Chiefs running back LeSean McCoy has been the lead back lately with Damien Williams (ribs) sidelined. However, Williams is listed as questionable for Sunday's Week 15 matchup with the Broncos. McCoy saw 11 rushing attempts for 39 yards during the Week 14 victory over New England. He might end up getting another start, but will battle with Darwin Thompson and Spencer Ware for carries. McCoy is basically a touchdown-dependent option that will be handcuffed to around 10 to 12 carries.

From RotoBaller

Damien Williams Dec 14 8:20pm ET

Kansas City Chiefs running back Damien Williams (ribs) is listed as questionable for Sunday's Week 15 matchup with the Denver Broncos. The Chiefs backfield is a mess with LeSean McCoy, Darwin Thompson, and Spencer Ware all in the mix. Williams has missed the last two games and could be limited, assuming he plays on Sunday. It's uncertain how many touches Williams would see even fully healthy. He's going to be a touchdown-dependent fantasy option that most owners should avoid for Week 15.

From RotoBaller

Patrick Mahomes Dec 14 8:10pm ET

Kansas City Chiefs quarterback Patrick Mahomes has thrown three touchdowns and two interceptions over his last three games. Mahomes is normally an elite fantasy option every week, but has been slowed down recently. He should bounce back nicely against the Denver Broncos in Week 15. Mahomes completed 10 of 11 passing attempts for 76 yards and one touchdown last time he faced the Broncos in Week 7. However, Mahomes was injured during the game, but was playing very well before that. Fantasy owners should feel confident that Mahomes will bounce back here.

From RotoBaller

Jameis Winston Dec 14 7:53pm ET

Tampa Bay Buccaneers QB Jameis Winston (knee, thumb), will play Sunday, Dec. 15, against the Detroit Lions, according to Jenna Laine of ESPN Saturday, Dec. 14. He is officially listed as questionable.

Fantasy Spin: Winston has produced much better fantasy numbers than real-world results this season. He threw for a season-high 456 yards last week against the Indianapolis Colts while matching a season-high with four touchdowns but he also threw three interceptions for the fourth time this season. He's a low-end QB1.

From TheHuddle

Terrell Suggs Dec 14 6:33pm ET

Free-agent LB Terrell Suggs (Cardinals) will strongly consider not reporting to any team that claims him on waivers by 4 p.m. ET Monday, Dec. 16, if not the Baltimore Ravens, according to league sources Saturday, Dec. 14.

From TheHuddle

Albert Wilson Dec 14 6:03pm ET

Miami Dolphins WR Albert Wilson (concussion) cleared the NFL's concussion protocol Saturday, Dec. 14, and is expected to be available for the game Sunday, Dec. 15, against the New York Giants.

Fantasy Spin: Wilson hasn't reached the end zone since Week 8 and he hasn't topped 33 receiving yards in a single game this season. He isn't a fantasy consideration in anything but the deepest of leagues, even in the great Week 15 matchup.

From TheHuddle

DeVante Parker Dec 14 5:53pm ET

Miami Dolphins WR DeVante Parker (concussion) cleared the league's concussion protocol Saturday, Dec. 14, and will be available to play against the New York Giants Sunday, Dec. 15.

Fantasy Spin: Parker has enjoyed a breakout season and had topped 130 receiving yards in two of his previous three games before leaving early due to injury last week. He's a WR2 in a great matchup against the Giants this week.

From TheHuddle

Joe Schobert Dec 14 5:53pm ET

Cleveland Browns LB Joe Schobert has not heard from the team in months in regard to a contract extension and will likely be allowed to walk in free agency, according to a league source Saturday, Dec. 14.

From TheHuddle

Paul Richardson Dec 14 4:33pm ET

Washington Redskins WR Paul Richardson (hamstring) was placed on the Reserve/Injured list Saturday, Dec. 14. OT Timon Parris was signed to the active roster from the practice squad.

From TheHuddle

Taiwan Jones Dec 14 4:33pm ET

Houston Texans RB Taiwan Jones (hamstring) won't travel with the team and has been ruled out of the game Sunday, Dec. 15, against the Tennessee Titans.

From TheHuddle

Jared Cook Dec 14 4:23pm ET

New Orleans Saints TE Jared Cook (concussion) practiced in full again Saturday, Dec. 14, and was taken off the Week 15 injury report.

Fantasy Spin: Cook is a top-flight TE1 due to his red-zone usage in the second half of the season. He has four touchdowns over his last four games.

From TheHuddle

Patrick Robinson Dec 14 4:23pm ET

New Orleans Saints LB Kiko Alonso (quad), OT Andrus Peat (forearm), S Vonn Bell (knee), CB Patrick Robinson (calf) and DB Johnson Bademosi (foot) didn't participate in practice Saturday, Dec. 14, and have been ruled out for the game Monday, Dec. 16, against the Indianapolis Colts. OT Terron Armstead (ankle), DE Cameron Jordan (abdomen), C Will Clapp (elbow), LB A.J. Klein (knee) and FB Zach Line (knee) were limited in practice but don't have injury designations.

From TheHuddle