Pittsburgh Steelers running back Jaylen Warren (knee) is still wearing a sleeve over his right leg, but he's practicing again on Wednesday, according to Alan Saunders of PGH Steelers Now. Warren injured his knee in Week 3 and was held out of the Week 4 victory over the Minnesota Vikings in Ireland as a result. The 26-year-old had last week's bye to heal up, so he might only end up missing one game. Backfield mate Kenneth Gainwell was heavily utilized in Ireland with Warren out, touching the football 25 times for 134 total yards and two touchdowns. Gainwell's big game could provoke the Steelers to give him more work moving forward, even when Warren returns. That's something fantasy managers will want to think about when setting their lineups going forward. Warren had 43 carries in his first three games, but he averaged a career-low 3.1 yards per tote. He has made up for his lack of efficiency on the ground with 11 receptions for 142 yards and a touchdown as a pass-catcher.

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The Los Angeles Chargers officially placed rookie first-round running back Omarion Hampton (ankle) on Injured Reserve on Wednesday, according to Adam Schefter of ESPN. In a corresponding move, Kimani Vidal was called up from the practice squad to the active roster. The Bolts also signed veteran pass-catching back Nyheim Hines to the practice squad. An ankle injury suffered in the Week 5 loss to the Washington Commanders is going to keep Hampton out for at least four games. The 22-year-old needs to be stashed in all fantasy formats in the meantime, though, as he should return to bell-cow duties when he's healthy. Heading into Week 6 against the Miami Dolphins, Vidal and Haskins figure to split the backfield workload, making both short-term waiver-wire solutions. Hampton has averaged a healthy 4.8 yards per carry for 314 yards and two touchdowns on the ground for L.A. in his first five NFL games.

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The Los Angeles Chargers promoted running back Kimani Vidal from the practice squad after placing Omarion Hampton (ankle) on Injured Reserve. With both Hampton and Najee Harris sidelined, Vidal could be asked to contribute immediately behind new lead back Hassan Haskins. The second-year runner has logged just 47 career carries for 173 yards but brings a proven track record of durability and production from his college days at Troy, where he totaled 1,661 rushing yards on 297 carries in 2023. At 5'8" and 215 pounds, Vidal offers a compact, powerful running style that fits well within the Chargers' offensive system. Fantasy managers in deeper leagues should monitor his role closely, as he could emerge as a complementary option in Los Angeles' backfield rotation.

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Carolina Panthers tight end Ja'Tavion Sanders (ankle) is healthy and set to resume practicing on Wednesday ahead of the team's Week 6 matchup with the Dallas Cowboys. Sanders has started all three games he's played this season, catching 11 of 14 targets while proving to be a reliable option in the passing game. His return provides a noticeable upgrade over Tommy Tremble and should help stretch the field for big-play receiver Tetairoa McMillan. With both Sanders and Xavier Legette back in action, the Panthers' offense appears poised to continue its recent surge after winning two of their last three games. Fantasy managers in deeper leagues should keep an eye on Sanders as a potential streaming option if his involvement continues to grow.

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Philadelphia Eagles running back Saquon Barkley (knee) practiced in full on Wednesday, clearing him for Thursday night's matchup against his former team. In his lone meeting with the Giants last season, Barkley exploded for 187 total yards and a touchdown on 19 touches. The Eagles are expected to feature him early and often as they look to establish the run against a defense that has struggled to contain opposing backs. Barkley has yet to surpass 100 rushing yards in a game this season, but his recent health progress and familiarity with the Giants' defensive scheme could set the stage for a long-awaited breakout performance. Fantasy managers should confidently keep him locked into lineups for Week 6.

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Carolina Panthers running back Chuba Hubbard (calf) did not practice on Wednesday, putting his Week 6 status in jeopardy and opening the door for Rico Dowdle to remain the featured back. Dowdle took full advantage of his opportunity last week, erupting for 234 total yards and a touchdown against the Dolphins in a breakout performance. If Hubbard remains sidelined, Dowdle should once again see a heavy workload in a revenge-game scenario versus his former team, the Dallas Cowboys. The matchup is favorable, as Dallas currently ranks 23rd in the league against the run. Fantasy managers should treat Dowdle as a strong RB2 option if he draws another start, while Hubbard's ongoing absence makes him a risky play for Week 6.

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Tampa Bay Buccaneers running back Bucky Irving (shoulder, ankle) remained sidelined at Wednesday's practice, putting his Week 6 status in serious doubt. He has now missed multiple sessions as he continues to recover from lingering injuries, leaving the Buccaneers to rely heavily on Rachaad White. White carried the load last week with 14 rushes for 41 yards and two touchdowns and should once again operate as the primary option against the 49ers. San Francisco's defense ranks 17th against the run, giving Tampa Bay a favorable matchup to continue establishing the run. Irving's absence limits his short-term fantasy outlook, but managers should keep him stashed in hopes of a potential return for the team's Week 7 matchup against the Lions.

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According to Nolan Bianchi of The Detroit News, Lions wide receiver Amon-Ra St. Brown is not practicing on Wednesday. The team has yet to provide an update on why the star wideout is being held out of action. Fantasy managers should pay close attention to the injury report later on Wednesday in case this injury is serious. However, given that it is only Wednesday, St. Brown will have two more opportunities to return to practice before Friday's final report. After his quiet showing in Week 1, St. Brown has gone on to average a stellar 26.0 PPR points per game. During this four-game stretch, he has tallied 90.5 yards per game and caught 7.8 receptions per game. If he were to miss time, Jameson Williams would slide into the WR1 role.

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Tampa Bay Buccaneers wide receiver Mike Evans (hamstring) continues to make progress in his recovery, though a firm return date remains uncertain. Head coach Todd Bowles offered an optimistic update Wednesday, saying, "He's coming along. He's healing. I can't tell you how fast or when, but he's healing." Despite Evans and Chris Godwin both missing time this season, Tampa Bay's passing offense hasn't missed a beat, ranking sixth in the NFL behind impressive play from rookie Emeka Egbuka. The Buccaneers' depth at receiver has helped keep the offense rolling, but Evans' eventual return would provide a major boost to an already dynamic unit. Fantasy managers should continue to monitor his practice participation ahead of the team's upcoming matchups.

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Baltimore Ravens quarterback Lamar Jackson (hamstring) will miss his fourth straight practice on Wednesday, according to Jamison Hensley of ESPN. The two-time MVP tweaked his hamstring in Week 4 and was held out of the Week 5 loss to the Houston Texans. It's looking likely that he will miss a second straight contest this Sunday versus the visiting Los Angeles Rams. The Ravens have their bye coming up in Week 7, which would allow Jackson another week of rest before potentially making his return in Week 8 against the Chicago Bears on Oct. 26. Reports earlier on Wednesday suggested that the 28-year-old is fighting an "uphill battle" to play in Week 6 against the Rams, so fantasy managers should keep him on their benches. Backup Cooper Rush, who struggled mightily last week against Houston, will be in line to make a second straight start for the 1-4 Ravens.

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Carolina Panthers wide receiver Jalen Coker (quadriceps) has officially been designated to return from Injured Reserve and will return to practice on Wednesday, according to a team release. The Panthers will now have 21 days to officially activate Coker from IR. The 23-year-old missed the first five games of the season due to a pretty serious quad injury that he suffered on Aug. 28, but he's making progress and could be ready to make his 2025 debut as early as this Sunday against the Dallas Cowboys. It's probably unlikely that we'll see Coker in pads and a helmet in Week 6, but this is a notice to fantasy managers seeking wideout depth to run to the waiver wire and add him. Xavier Legette's return from injury and big game in Week 5 kind of puts a damper on Coker's fantasy value right now, but the second-year wideout could still have a big role in Carolina's passing game when he returns after posting a 32-478-2 line in 11 games in his rookie campaign.

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Cincinnati Bengals head coach Zac Taylor said that veteran quarterback Joe Flacco, whom the team acquired in a trade from the division-rival Cleveland Browns this week, will make his debut and start on Sunday at the Green Bay Packers in Week 6, per ESPN's Adam Schefter. The Bengals are benching Jake Browning after he tossed three more interceptions in the Week 5 loss to the Detroit Lions. Cincy plans to lean heavily on Flacco to try and keep their playoff hopes alive, with Joe Burrow (toe) potentially out for the rest of the season. Flacco will once again be in play as a low-end QB2 streamer in superflex fantasy leagues, and he should have more upside now that he'll be throwing to receivers Ja'Marr Chase and Tee Higgins. However, the 40-year-old might not end up being much of an upgrade over Browning after he threw two touchdowns and six picks in four starts with Cleveland before being benched by rookie Dillon Gabriel.

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Washington Commanders head coach Dan Quinn said that wide receiver Terry McLaurin (quadriceps) will not return to practice on Wednesday, according to Nicki Jhabvala of The Washington Post. Meanwhile, fellow wideout Noah Brown (groin, knee) will return to the practice field after missing the last three games. McLaurin has missed the last two games, and his absence from practice isn't a great sign that he will be able to return for a Monday night contest in Week 6 against the Chicago Bears. The 30-year-old pass-catcher still has three more days of official practices to try and get back on the field this week, but fantasy managers shouldn't get their hopes up with Scary Terry. If he misses a third straight game on Monday, Deebo Samuel Sr. will continue to soak up targets, as will Luke McCaffrey and rookie Jaylin Lane. McLaurin hasn't practiced since injuring his quad in Week 3.

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Arizona Cardinals head coach Jonathan Gannon said that quarterback Kyler Murray (foot) will not practice on Wednesday, according to Darren Urban of AZCardinals.com. Gannon added that the team will see how the week goes for Murray. The 28-year-old signal-caller injured his foot in the second half of the Week 5 loss to the Tennessee Titans, but he only ended up missing three snaps and was able to finish out the game. The fact that Murray was able to come back and finish Sunday's game was encouraging, but a missed practice on Wednesday could mean that his status for Week 6 against the Indianapolis Colts is up in the air. Murray's performance early in 2025 has left a lot to be desired from his fantasy managers, and now they could be without him this weekend. Start searching for backup plans if you don't already have one. If Murray is unavailable against the Colts, veteran Jacoby Brissett would be forced into starting duties at QB.

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New York Giants running back Tyrone Tracy Jr. (shoulder) was removed from the final Week 6 injury report on Wednesday and will be active to face the division-rival Philadelphia Eagles on Thursday Night Football, according to Dan Salomone of Giants.com. Tracy will be returning from a two-game absence due to a dislocated right shoulder that he suffered in the Week 3 loss to the Kansas City Chiefs. It's good news for the Giants' offense, but Tracy's fantasy managers may want to temper expectations in his first game back. Rookie Cam Skattebo handled lead-back duties in Tracy's absence and is expected to be the preferred backfield option moving forward over Tracy. In the first three games of the year, Tracy averaged just 3.1 yards per carry for 68 yards on 22 rushing attempts. We'd recommend fading Tracy in fantasy in his first game back, especially in a poor matchup.

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New York Giants wide receiver Darius Slayton (hamstring) has been ruled out for the Thursday night divisional game in Week 6 against the Philadelphia Eagles, according to Dan Salomone of Giants.com. This was the expected result after Slayton injured his hamstring on Sunday in the Week 5 loss to the New Orleans Saints. He was unable to practice leading up to Thursday's game. The good news is that the 28-year-old will have extra time to get ready for a potential return in Week 7 against the Denver Broncos. Without Slayton in the fold in a tough matchup against Philly, Wan'Dale Robinson should be the favorite target of rookie quarterback Jaxson Dart in the passing game, with Jalin Hyatt and Beaux Collins also starting in three-wide sets. Tight ends Theo Johnson and Daniel Bellinger should also be more involved in the passing attack on Thursday.

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New York Giants rookie quarterback Jaxson Dart (hamstring) was removed from the injury report on Wednesday and will play on Thursday night in Week 6 against the division-rival Philadelphia Eagles, according to Dan Salomone of Giants.com. The 22-year-old first-rounder came out of the Week 5 loss to the New Orleans Saints with a sore left hamstring, but it was never really viewed as anything serious, even heading into a short week. Dart upset the Los Angeles Chargers in Week 4 in his first NFL start, but he took a step back and committed three turnovers on Sunday to give the Saints their first win of the season. There are going to be plenty of ups and downs for Dart in his rookie season, especially with top wideout Malik Nabers (knee) lost for the year. Dart's dual-threat abilities give him upside as a QB2 in fantasy, although he'll be one to fade against a tough Eagles defense that is coming off their first loss of the year.

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Tampa Bay Buccaneers head coach Todd Bowles has had no update on running back Bucky Irving's (foot, shoulder) return, but his being out for a bit factored into the team signing RB Owen Wright to their practice squad, according to the Pewter Report. Irving did not play in the Week 5 win over the Seattle Seahawks on Sunday, and ESPN's Adam Schefter has reported that he's likely to miss Week 6 against the San Francisco 49ers as well. The 23-year-old is dealing with a left-foot sprain and a shoulder subluxation, with his shoulder injury being considered more severe. Fantasy managers should keep Irving on their benches until further notice. He appears to be trending down to play this weekend, and it's unclear if he'll be ready for a Monday night showdown in Week 7 against the Detroit Lions. Rachaad White scored twice as Tampa's lead back in Week 5 and should be considered a plug-and-play RB2 again this week if Irving is officially ruled out.

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Miami Dolphins kicker Jason Sanders (hip) is not ready to return for a Week 6 contest this Sunday against the visiting Los Angeles Chargers, according to head coach Mike McDaniel. Sanders remains on Injured Reserve and has yet to kick in 2025 due to his hip injury. His next chance to make his season debut will come next week when the team travels to Cleveland to take on the Browns. Riley Patterson should handle the kicking duties in Miami for at least another week. The 26-year-old has been perfect through five games, filling in for Sanders, but the problem is that he hasn't had much volume for fantasy purposes. He's gone 5-for-5 on his field-goal tries, including four makes from 40-49 yards out, and 12-for-12 on his extra-point opportunities. Patterson has been money so far, but fantasy managers should have better streaming options in Week 6 at kicker.

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The Cleveland Browns have said numerous times that they are trying to develop rookie fifth-round quarterback Shedeur Sanders "very intentionally," according to Mark Kay Cabot of The Cleveland Plain Dealer. Head coach Kevin Stefanski said he has to do what's best for the players as well as the team. It's why Stefanski has not yet named Sanders as the No. 2, even though Cleveland traded veteran Joe Flacco to the division-rival Cincinnati Bengals this week. Sanders looked good during the preseason and has been praised by the coaching staff for the work he's been putting in, and although the 23-year-old is expected to see the field at some point in 2025, the Browns aren't going to rush that moment. He could be active for the first time this year as the backup to fellow rookie Dillon Gabriel this weekend against the division-rival Pittsburgh Steelers, unless the Browns choose to elevate Bailey Zappe from the practice squad into the QB2 role.

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