The Los Angeles Rams listed tight end Tyler Higbee (hip) as a non-participant on their estimated practice report on Monday, according to Adam Grosbard of the Los Angeles Daily News. Meanwhile, fellow tight end Colby Parkinson (shoulder) was estimated as limited. Higbee was limited last Thursday and then didn't practice on Friday, but he still played through a questionable tag in the Week 4 win over the Indianapolis Colts and led all TEs on the team with a 55% snap share. The 32-year-old caught just two of five targets for 25 yards, though, and won't be a realistic starting fantasy TE for Thursday night's matchup against the San Francisco 49ers if he's active. Through four weeks in 2025, Higbee has caught six of 11 targets for 62 scoreless yards. He hasn't caught a pass in two of his four games and should remain a low-volume TE2 with receivers Puka Nacua and Davante Adams hogging most of the targets from quarterback Matthew Stafford.

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Carolina Panthers wide receiver Xavier Legette (hamstring) remains day-to-day, according to David Newton of ESPN. Legette picked up a hamstring injury in Week 2 and hasn't played since. With Legette banged up and Jalen Coker (quadriceps) still week-to-week and not particularly close to returning from Injured Reserve, the Panthers are looking forward to getting rookie Jimmy Horn Jr. involved going forward. The 24-year-old Legette was unable to practice at all last week, although he could have a shot at returning for a Week 5 matchup against the Miami Dolphins if he gets back on the field this week. The Panthers need all the help they can get in the passing attack behind rookie first-rounder Tetairoa McMillan, who has been the only consistent target for quarterback Bryce Young. Legette has caught only four of his 15 targets in two games for eight yards. He should be on the waiver wire in 12-team leagues.

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Dynasty | Dolphins receiver Tyreek Hill suffered a left knee injury and was carted off the field on Monday Night Football. Dynasty Analysis: This one was gruesome. In fact, most were surprised they even showed it on replay. We don't need to get into the graphic details of it. All you need to know is Hill had to be sent to the hospital with an air cast on his leg. You would expect to learn soon about him having surgery and it's clear his season has to be over. This will be a career-defining injury for Hill, who will undoubtedly be 32 by the time he's back on the field, if he even chooses to be back. Stay tuned on clear details but this was clearly not good.

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New York Giants head coach Brian Daboll said that he expects that rookie first-round quarterback Jaxson Dart (hamstring) will be able to practice on Wednesday, according to Patricia Traina of SI.com. Dart apparently injured his hamstring in his first career win over the Los Angeles Chargers in Week 4 on Sunday, but he finished out the game and should be alright to make his second career start in Week 5 in a great matchup against the winless New Orleans Saints. The 22-year-old went 13-for-20 passing for 111 yards and a touchdown against L.A., rushing 10 times for 54 yards and another touchdown. Dart gave the G-Men a spark and helped them beat a strong defense, but the news of receiver Malik Nabers' (knee) season-ending injury puts a damper on the offense moving forward. Still, Dart has the potential to be a nice QB2 streamer with upside in the Big Easy in his second NFL start, given his dual-threat abilities.

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San Francisco 49ers quarterback Mac Jones (knee) was listed as a full participant on Monday's estimated practice report, according to Cam Inman of the Bay Area News Group. Meanwhile, Brock Purdy (toe) was listed as a non-participant after coming out of Sunday's Week 4 loss to the Jacksonville Jaguars with soreness in his toe. Purdy missed Weeks 2 and 3 due to turf toe and a sprained AC joint in his left shoulder, and he could be in danger of missing a third game in a short turnaround in Week 5 on Thursday night against the division-rival Los Angeles Rams. Jones suffered a PCL sprain in the Week 3 win over the Arizona Cardinals, but he was active as Purdy's backup in Week 4. If Purdy doesn't get cleared to play on Thursday night, Jones will make his third start of the year in a tough matchup against L.A. Jones would be nothing more than a low-end QB2 streamer in two-QB superflex formats if he gets another starting nod.

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Baltimore Ravens head coach John Harbaugh said that quarterback Lamar Jackson (hamstring) was not in a position to return to Sunday's game against the Kansas City Chiefs in Week 4 after he tweaked his hamstring. "There was no way Lamar was going back into the game. The injury precluded it," Harbaugh said. Before Jackson left the game, he went 14-for-20 passing for 147 yards with a touchdown and an interception, adding six carries for 48 yards on the ground. Backup Cooper Rush replaced the 28-year-old superstar, who is now in danger of missing the Week 5 contest against the Houston Texans. At the time of Jackson's injury, the Ravens were down by multiple scores, leading many to believe the Ravens simply thought it was pointless to bring him back with the game likely already lost. Jackson's status will be closely watched this week. If Rush is forced to start against a stingy Texans defense, it will be a downgrade in fantasy for all of Baltimore's other offensive weapons.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) was listed as a non-participant on the team's Monday injury report, per Cam Inman of Bay Area News Group. The 49ers did not actually practice on Monday, so this is an estimation of Pearsall's current status heading into his Thursday night Week 5 matchup against the Los Angeles Rams. 49ers head coach Kyle Shanahan previously said that Pearsall suffered a "minor PCL" injury in Week 4. Pearsall has recorded 20 catches for 327 yards on 29 targets so far this season. It appears San Francisco could be without both Pearsall and wideout Jauan Jennings (ankle, ribs) on Thursday. If that's the case, 49ers wide receivers Kendrick Bourne and Demarcus Robinson would likely both be in line for a significant increase in playing time.

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San Francisco 49ers wide receiver Jauan Jennings (ankle, ribs) was listed as a non-participant on the team's Monday injury report, according to Cam Inman of Bay Area News Group. Inman notes that San Francisco did not actually practice on Monday, so this is an estimation from the team on what Jennings' practice status would be heading into their Week 5 matchup against the Los Angeles Rams on Thursday night. The 28-year-old has dealt with myriad injuries this season and picked up a rib ailment in Week 4. In the three games he's been able to play in, Jennings has recorded nine catches for 129 yards and a touchdown on 19 targets. If he's unable to suit up on Thursday, 49ers wideouts Kendrick Bourne and Demarcus Robinson could see an increase in playing time alongside Ricky Pearsall (knee), who is dealing with a knee injury of his own. If Jennings is active, he profiles as a low-end fantasy WR3/flex option in Week 5.

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Miami Dolphins wide receiver Tyreek Hill (knee) is believed to have suffered a dislocated knee during his team's Week 4 matchup against the New York Jets, according to Ian Rapoport of NFL Network. Hill was carted off the field in the third quarter with an Aircast on his left leg. The 31-year-old recorded six catches for 67 yards before getting injured in Week 4. If Hill ends up missing significant time, Dolphins wide receivers Jaylen Waddle and Malik Washington would likely see an increase in targets, as would tight end Darren Waller. Miami running back De'Von Achane's pass-game usage could also be elevated to even further heights.

From RotoBaller

Updating previous reports, Miami Dolphins WR Tyreek Hill (knee) is believed to have a suffered a dislocated knee during the Week 4 game, according to a source.

Fantasy Spin: Fantasy players will need to look for a possible timeline for Hill, but he will likely miss an extended period of time. Jaylen Waddle will take over as the No. 1 receiver for the Dolphins and can be a No. 2 or No. 3 receiver in fantasy leagues.

From TheHuddle

Indianapolis Colts head coach Shane Steichen said that wide receiver Adonai Mitchell is "going to have to earn" more opportunities going forward after his costly fumble in the team's Week 4 loss to the Los Angeles Rams. Mitchell recorded three catches for 96 yards on four targets against Los Angeles, but dropped the ball just before crossing the goal line on what should have been a 70-plus-yard touchdown. The 22-year-old has logged seven catches for 137 yards on 12 targets through four games this season. He saw increased playing time in Week 4 with Colts wideout Alec Pierce (concussion) sidelined. If Pierce returns for the team's Week 5 matchup against the Las Vegas Raiders, Mitchell could have a hard time getting on the field.

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Dallas Cowboys head coach Brian Schottenheimer said rookie running back Jaydon Blue is "very close" to being active on game day and has been practicing "really, really well," per Jon Machota of The Athletic. Blue has been inactive for each of the Cowboys' first four games of 2025. Javonte Williams has been the workhorse back in Dallas so far this season, with fellow veteran back Miles Sanders (ankle) serving as the RB2. Sanders is reportedly trending towards playing in Week 5 after suffering an ankle injury in Week 4. Still, his health status could be a factor in the team's decision on whether to activate Blue. The Cowboys will face the New York Jets in Week 5, which would be a favorable matchup for Blue if he is indeed called upon to make his NFL debut.

From RotoBaller

Updating a previous report, Miami Dolphins WR Tyreek Hill (knee) suffered a knee injury during the Week 4 game and has been ruled out. Hill will be taken to a Miami hospital for imaging, evaluation and observation.

Fantasy Spin: Hill probably will miss an extended period of time, but fantasy players should know more in the next day or two. Jaylen Waddle and Darren Waller will receive bigger roles in the passing game. Waddle will be a No. 2 or No. 3 receiver in fantasy leagues, while Waller can become a low-end No. 1 tight end after a strong Week 4 performance.

From TheHuddle

Miami Dolphins wide receiver Tyreek Hill (knee) was forced to exit in the third quarter of his team's Week 4 matchup against the New York Jets with a left-knee injury. Hill's leg buckled underneath him awkwardly, and he was carted off the field with an Aircast on. It's too early to say exactly what the injury is, but it certainly doesn't look good for the 31-year-old wideout. According to NFL Network's Ian Rapoport, Hill has been ruled out and is being taken to a local hospital for imaging and evaluation. Hill will finish Week 4 with six catches for 67 yards. In his absence, Dolphins wide receivers Jaylen Waddle and Malik Washington should both see an uptick in targets. Veteran tight end Darren Waller and running back De'Von Achane could also see increased usage in the Miami passing game.

From RotoBaller

Miami Dolphins WR Tyreek Hill (leg) was carted off the field after suffering a leg injury during the Week 4 game.

Fantasy Spin: Hill appeared to have suffered a serious injury, so fantasy players should expect an extended absence. Jaylen Waddle will be the main receiver for the Dolphins and will be a weekly starting option in all leagues. Darren Waller will also a bigger role in the passing game and can be a low-end No. 1 tight end in leagues.

From TheHuddle

Detroit Lions tight end Sam LaPorta recorded three catches for 39 yards on four targets in his team's Week 4 win over the Cleveland Browns. LaPorta has now earned exactly four targets and failed to crack 40 yards in each of Detroit's last three games. For the season, the 24-year-old has logged 16 catches for 177 yards and zero touchdowns on 21 targets. On the bright side, LaPorta is tied for second on the Lions in targets with running back Jahmyr Gibbs, behind only star wideout Amon-Ra St. Brown (32). Still, LaPorta has not been able to provide consistent fantasy production so far in 2025. He has a favorable matchup on paper in Week 5 against the Cincinnati Bengals, but LaPorta may need to find the end zone to be a worthwhile fantasy starter.

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New York Jets running back Braelon Allen (knee) suffered a knee injury in the first half of the Monday night game against the division-rival Miami Dolphins and has already been ruled out, according to Tom Pelissero of NFL Network. Allen's knee took a pretty nasty shot in the second quarter on a kickoff return. The 21-year-old was able to walk to the locker room under his own power, but he was quickly ruled out. Before the injury, he carried the ball four times for 26 yards. With Allen out the rest of the way to close out Week 4 action, Isaiah Davis will see more work in New York's backfield as a change-of-pace option behind Breece Hall. Allen came into Monday night's action with 14 rushing attempts for 50 yards (3.6 yards per game) and one rushing touchdown in three games in a struggling Jets offense. He's merely been a handcuff for Hall's owners, but it's possible he won't be able to play in Week 5 against the Dallas Cowboys.

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Arizona Cardinals WR Zay Jones (concussion) participated in practice Monday, Sept. 29.

From TheHuddle

Detroit Lions quarterback Jared Goff did not have his best statistical day against a top-notch defense in his team's Week 4 win over the Cleveland Browns. Goff completed 16 of 27 pass attempts for 168 yards, two touchdowns, and one interception. On the season, the 30-year-old has now completed 73.8% of his pass attempts for 929 yards, nine touchdowns, and two interceptions. Goff has shown the potential for gaudy touchdown totals over the past couple of years in this Lions offense, but his lack of rushing ability (11 rushing yards this season) limits his fantasy ceiling. He profiles as a matchup-dependent low-end starter in single-quarterback leagues, and has a favorable matchup on paper in Week 5 against the Cincinnati Bengals.

From RotoBaller

Detroit Lions rookie wide receiver Isaac TeSlaa was held without a catch for the second straight game in Week 4 by the Cleveland Browns. TeSlaa burst onto the scene with a pair of highlight-reel grabs over his first two NFL games, but he remains limited to a minor role in the Detroit offense for the time being. The 23-year-old played just 20% of the Lions' offensive snaps in Week 4 and is firmly behind Detroit wideouts Amon-Ra St. Brown, Jameson Williams, and Kalif Raymond on the team's depth chart at the position. All told, TeSlaa has two catches for 42 yards and a touchdown on four targets so far this season. He maintains some appeal in dynasty leagues, but TeSlaa should be off the radar of fantasy managers in redraft formats.

From RotoBaller