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Players: Emmanuel Sanders, Marquise Goodwin, Jimmy Garoppolo, George Kittle, Dante Pettis, Andy Isabella, Kyler Murray

San Francisco 49ers quarterback Jimmy Garoppolo (10) passes against Seattle Seahawks defensive tackle Quinton Jefferson (99) during the second half of an NFL football game in Santa Clara, Calif., Monday, Nov. 11, 2019. (AP Photo/Tony Avelar)


Arizona Cardinals quarterback Kyler Murray (1) throws a pass against the Tampa Bay Buccaneers during the first half of an NFL football game Sunday, Nov. 10, 2019, in Tampa, Fla. (AP Photo/Jason Behnken)


SANTA CLARA, Calif. (AP) After nothing but success the first eight games of the season, the San Francisco 49ers now are learning to deal with failure.

The Niners' perfect season was derailed last week with an overtime loss to the Seattle Seahawks when San Francisco was unable to overcome a litany of offensive miscues.

The 49ers (8-1) will look to get back on the winning track Sunday when they host the Arizona Cardinals (3-6-1) for the second time in three weeks.

''I think we have a good mindset with it,'' said quarterback Jimmy Garoppolo, who had his worst day of the season in the 27-24 loss. ''Everyone was in here yesterday working on the day off. Today it's just a sense of urgency in the building. It's good to see that.''

San Francisco committed three turnovers, allowed five sacks and struggled to get much of anything going consistently on the ground or through the air against Seattle.

The 49ers had season lows in yards rushing (87) and yards per attempt passing (4.7) on a night that star tight end George Kittle was out with an injury and No. 1 receiver Emmanuel Sanders left with injured ribs in the first quarter.

San Francisco is using that performance as a teaching tool for the rest of the season.

''You learn from the good and you learn more from the bad,'' tackle Mike McGlinchey said. ''It's a huge step in the right direction for us to be able take as many blows as we did and play as poorly as we did and still have a chance, not only one chance but multiple chances to win that game. That's a testament to how our defense played. ... We need to do a better job on the offensive side of the ball to make sure we reward their work.''

The Cardinals are stumbling toward their bye week, having lost three straight games after a promising start to the first season under coach Kliff Kingsbury and rookie quarterback Kyler Murray.

One of those losses was two weeks ago when Arizona fell 28-25 at home to the 49ers, a performance that gives the Cardinals confidence that if they can fix some mistakes they can compete with the first-place Niners.

''I don't think we played our best game,'' Murray said. ''I know personally, if we just go out and execute - they know what we do, we know what they do - if we go out and execute, we should be in good shape.''

MISSING TARGETS

The Niners' offense was done in by the absence of Kittle and Sanders last week. San Francisco scored 10 points on the opening two drives when Sanders was healthy and then just six more on offense the rest of the game. With no consistent receiving threats, the Seahawks were able to load up against the run and allow only 3.2 yards per carry. Kendrick Bourne had two key drops for San Francisco, while Dante Pettis and Marquise Goodwin combined for no catches on six targets.

ISABELLA ARRIVES

Arizona has relied on a variety of playmakers this season and the latest to make big plays is rookie receiver Andy Isabella. The second-round pick out of UMass had an 88-yard touchdown catch against the 49ers in the first meeting between the teams on Oct. 31. He has six catches for 174 yards over the past three games after not even being targeted in the season's first seven games. Kingsbury said Isabella has been improving steadily all season.

''It's been trending that way for a while,'' he said. ''We've had him inside, had him outside, and I think now the comfort level, having him outside more so, has really helped his development recently.''

MAN IN THE MIDDLE

The defensive star of the game for the 49ers last week was middle linebacker Fred Warner, who stepped up his performance in his first game since fellow starting linebacker Kwon Alexander suffered a season-ending torn pectoral muscle. Warner had 10 tackles, the first two sacks of his career, one forced fumble and a pass defensed.

''He gets us in and out of everything,'' coach Kyle Shanahan said. ''He has to make a ton of calls. He's definitely our quarterback out there and I think he does it as good as anyone I've seen.''

DEFENSIVE TROUBLES

Arizona's defense ranks 31st out of 32 teams in points allowed (281), total yards allowed per game (412.5) and passing yards allowed per game (286.5). The Cardinals have given up at least 21 points in all 10 games this season but never have given up more than 38. Linebacker Chandler Jones has been one of the bright spots with 11 1/2 sacks and five forced fumbles. Three-time All-Pro cornerback Patrick Peterson returned from a six-game suspension last month but hasn't had much of an impact. Kingsbury said the Cardinals had bouts of poor tackling in last week's 30-27 loss to Tampa Bay.

''There were some shoulders being thrown,'' Kingsbury said. ''We have to be better in those situations.''

BLIND SIDE

The 49ers again will be without starting left tackle Joe Staley, who will be out a couple of weeks after undergoing surgery on a broken finger. Staley broke a bone in his leg in Week 2 and missed the next six games. He then got hurt in his return to the lineup. With Staley unable to go, rookie Justin Skule is expected to move back into the lineup.

''I thought he did a very good job,'' Shanahan said of Skule. ''He came in there and stepped it up right away. Did a good job in his first game and I thought he got better each week.''

Player Notes
Marquise Goodwin Dec 11 12:50am ET

The San Francisco 49ers placed wide receiver Marquise Goodwin (foot, knee) on injured reserve on Tuesday. The seven-year pro has been dealing with chronic leg issues and will be shut down to undergo treatment. Goodwin managed just 12 catches for 186 yards and a touchdown in 2019 and its probable his three-year tenure with the Niners is over. The speedster will likely find his way onto another roster next year but at 29 years old, Goodwin holds minimal dynasty value. With Goodwin shelved, wideout Kendrick Bourne will continue operating as the primary third receiver. With five scores over his past six games, Bourne has emerged as a red zone threat and will be a low-volume WR5 in Week 15 against the Atlanta Falcons.

From RotoBaller

Marquise Goodwin Dec 10 5:33pm ET

San Francisco 49ers WR Marquise Goodwin (knee) was placed on the Reserve/Injured list with a knee injury on Tuesday, Dec. 10.

From TheHuddle

Demaryius Thomas Dec 10 5:23pm ET

New York Jets S Jamal Adams (ankle), OT Chuma Edoga (knee), TE Ryan Griffin (ankle), CB Arthur Maulet (calf), CB Brian Poole (concussion), RB Bilal Powell (ankle, illness), WR Demaryius Thomas (hamstring, knee) and DL Quinnen Williams (neck) did not practice Tuesday, Dec. 10. OT Kelvin Beachum (ankles), S Matthias Farley (ankle), DL Steve McLendon (knee, hip), RB Ty Montgomery (foot, hip) and DL Nathan Shepherd (ankle) were limited. RB Le'Veon Bell (illness), CB Maurice Canady (shoulder), OL Tom Compton (ankle), QB Sam Darnold (knee, thumb), QB David Fales (elbow) and LB Paul Worrilow (quad) participated in full.

From TheHuddle

Mark Ingram Dec 10 5:13pm ET

Baltimore Ravens LB Chris Board (concussion), DB Anthony Levine (ankle), OT Ronnie Stanley (concussion), RB Mark Ingram (non-injury), S Earl Thomas (non-injury) and DT Brandon Williams (non-injury) did not practice Tuesday, Dec. 10. TE Mark Andrews (knee), QB Lamar Jackson (quad) and DE Jihad Ward (elbow) were limited.

From TheHuddle

Calvin Ridley Dec 10 4:53pm ET

Atlanta Falcons WR Calvin Ridley (abdominal) and CB Desmond Trufant (forearm) were placed on the Reserve/Injured list on Tuesday, Dec. 10. LB Ahmad Thomas was signed to the active roster, while TE Carson Meier and LB Quentin Poling were added to the practice squad.

From TheHuddle

Alshon Jeffery Dec 10 4:43pm ET

Philadelphia Eagles WR Alshon Jeffery (foot) is out for the rest of the season with a foot injury he suffered in Week 14 against the New York Giants, according to a source. The team is still reportedly gathering opinions about the exact injury, however.

Fantasy Spin: This injury wraps up yet another injury-shortened season for the 29-year-old, who has played a full season once in the last five years - averaging only 12 games over that span. Jeffrey is still due $12.75 million over each of the final two years of his deal, so he's probably not going anywhere this offseason. With Nelson Agholor also ailing, the Eagles could be forced to finish the season with Greg Ward, J.J. Arcega-Whiteside and a few practice squad players at the position.

From TheHuddle

Rodney Gunter Dec 10 4:33pm ET

Arizona Cardinals DL Rodney Gunter (toe) was placed on the Reserve/Injured list with a toe injury on Tuesday, Dec. 10. DL Caraun Reid (Cardinals) was re-signed to an undisclosed contract to replace him on the roster after getting released over the weekend.

From TheHuddle

Simeon Thomas Dec 10 4:23pm ET

Washington Redskins CB Simeon Thomas was handed a four-game suspension by the NFL on Tuesday, Dec. 10, for violating the league's policy and program on substances of abuse.

From TheHuddle

Marvin Jones Dec 10 4:23pm ET

Detroit Lions WR Marvin Jones (ankle) was placed on the Reserve/Injured list with an ankle injury on Tuesday, Dec. 10.

Fantasy Spin: The hits just keep coming for Detroit, which figures to lean on Kenny Golladay even more the rest of the way. Danny Amendola should also see more targets as well.

From TheHuddle

Auden Tate Dec 10 3:40pm ET

Cincinnati Bengals wide receiver Auden Tate (knee) was placed on the injured reserve Tuesday, ending his season. Tate sustained a mild MCL sprain in his left knee in the third quarter of the teams Week 14 loss to the Cleveland Browns. Damion Willis was promoted to the active roster in a corresponding roster move. Tate took advantage of all the injuries to the Bengals receiving corps this season, racking up a career-high 40 catches for 575 yards and one touchdown, and is a worthy hold in dynasty leagues heading into his third season.

From RotoBaller

Cooper Kupp Dec 10 3:23pm ET

Los Angeles Rams WR Cooper Kupp played only 20 of a possible 68 snaps in Week 14 versus the Seattle Seahawks.

Fantasy Spin: By comparison, Kupp logged 57 snaps in Week 13. Head coach Sean McVay defended the move by suggesting it was the cost of doing business in order to establish some offensive balance on early downs. However, the flaw in that reasoning is that Kupp's playing time should not be cut in favor of backup tight end Johnny Mundt. Meanwhile, Brandin Cooks didn't make a catch in his 61 snaps. Expect Kupp to return to his normal snap count in Week 15 against the Dallas Cowboys.

From TheHuddle

Jamar Taylor Dec 10 3:13pm ET

Free-agent CB Jamar Taylor (Seahawks) signed an undisclosed contract with the Atlanta Falcons on Tuesday, Dec. 10.

From TheHuddle

Le'Veon Bell Dec 10 3:03pm ET

New York Jets RB Le'Veon Bell is among the players the team is expected to make available via trade this offseason, according to sources.

Fantasy Spin: Bell is averaging only 49.1 yards rushing behind one of the league's worst offensive lines in his first season with the Jets, and it is becoming increasingly clear head coach Adam Gase either can't find a way to keep him involved in the offense or doesn't want to. A trade will be hard to accomplish as well, as the Jets would take a $15.5 million cap hit if they deal him and his hypothetical new team would have to find a way to fit one of the larger contracts at his position onto the roster.

From TheHuddle

Auden Tate Dec 10 2:53pm ET

Cincinnati Bengals WR Auden Tate (knee) was placed on the Reserve/Injured list with a sprained left medial collateral ligament Tuesday, Dec. 10. WR Damion Willis was elevated from the practice squad to replace him on the roster.

Fantasy Spin: Tate's emergence was probably the best thing to happen to the Bengals in an otherwise lost season. Assuming A.J. Green re-signs with the team in the offseason, Tate will probably push John Ross for the other starting outside job while Tyler Boyd remains the main slot receiver. Tate, who finishes this season with 40 catches for 575 yards and a touchdown, should be considered a solid late-round flier next summer in fantasy drafts.

From TheHuddle

Cedrick Wilson Dec 10 2:43pm ET

Dallas Cowboys WR Cedrick Wilson (knee) was placed on the Reserve/Injured list Tuesday, Dec. 10. OT Mitch Hyatt was elevated from the practice squad to replace him on the roster.

From TheHuddle

Parris Campbell Dec 10 2:40pm ET

Indianapolis Colts wide receiver Parris Campbell (foot) has been placed on Injured Reserve ending his season. It's an unfortunate, yet fitting, end to the rookie's season having battled injuries to his hamstring, abdomen, and a broken hand before a fractured foot put him on season-ending IR. Campbell finishes his rookie season with 18 catches for 127 yards and one touchdown. The Colts are still unsure of T.Y. Hilton's (calf) status for their Monday night game vs New Orleans, but it's looking increasingly likely Hilton misses the game. Assuming Hilton is out, Zach Pascal has interesting WR3 value with Marcus Johnson also in the mix in deeper fantasy leagues.

From RotoBaller

James Conner Dec 10 2:30pm ET

The Pittsburgh Steelers are expecting to get wide receiver JuJu Smith-Schuster (knee) and running back James Conner (shoulder) back in time for their Week 15 game against the Buffalo Bills. Neither has played since getting injured against the Cleveland Browns in Week 11. Both players are expected to practice this week in what would be a big boost to the Pittsburgh offense as the team looks to remain in the playoff picture. Conner's return would come at an especially good time as Jaylen Samuels is looking questionable for this weekend with a groin injury. That being said, fantasy GMs need to temper their expectations for both players as the Bills have been stout on defense this season.

From RotoBaller

Calvin Ridley Dec 10 2:20pm ET

Atlanta Falcons wide receiver Calvin Ridley (abdomen) will be out for the remainder of the season after suffering an abdominal injury during the first half of Week 14's win over the Carolina Panthers. Ridley had a big game before the injury, catching five balls for 76 yards and a touchdown but went down before halftime and was unable to stand on his own. He was carted off the field and looked to be in significant pain. With Ridley out look for Russell Gage to slide in as the No. 2 receiver in Atlanta opposite Julio Jones. Gage is worth a look as a flex play in fantasy leagues going forward.

From RotoBaller

Bilal Powell Dec 10 2:20pm ET

New York Jets running back Bilal Powell (ankle, illness) is not expected to play Thursday night at Baltimore. Powell, who was filling in for Le'Veon Bell (illness) injured his ankle at the end of the Jets Week 14 win over the Dolphins. Powell is also apparently dealing with the flu but head coach Adam Gase said the ankle is the bigger concern right now. Powell is yet to officially be ruled out, but all signs are pointing to him not suiting up this week. The good news for New York is Bell is reportedly close to 100 percent and should reclaim his starting role with Ty Montgomery working as a change of pace back. Powell can safely be dropped by those that picked him up for the Miami game.

From RotoBaller

D.J. Chark Dec 10 2:10pm ET

Jacksonville Jaguars wide receiver D.J. Chark (ankle) was spotted in a walking boot on Monday and left the locker room using a scooter. Head coach Doug Marrone told reporters that Chark is "week-to-week" with the injury, which puts the remainder of his season in jeopardy. Chark broke out in a big way for Jacksonville in 2019, catching 67 balls for 956 yards and eight touchdowns. With Chark sidelined, look for Dede Westbrook, Chris Conley, and Keelan Cole to all see more chances within the Jacksonville passing attack.

From RotoBaller