Michael Busch homered to lead off the ninth inning, lifting the host Chicago Cubs to a walk-off, 3-2 victory over the San Diego Padres on Tuesday.

Busch deposited a first-pitch fastball from Enyel De Los Santos (1-2) over the wall in right-center field. The homer was Busch's seventh of the season and first since he went deep in five straight games from April 10-15.

The blast made a winner out of Hector Neris (2-0), who overcame a single and a walk to record a scoreless top of the ninth.

Jurickson Profar belted a two-run homer while Fernando Tatis Jr. and Jose Azocar had two hits apiece, but the Padres fell for the second time in three games. Jake Cronenworth reached on a sixth-inning single to extend his hitting streak to 11 games.

Brewers 6, Royals 5

Willy Adames slammed a three-run homer in the ninth inning as visiting Milwaukee rallied past Kansas City.

Rhys Hoskins and Joey Ortiz led off the second inning with back-to-back homers off Kansas City starter Seth Lugo. Jared Koenig (3-1) allowed two hits in 1 1/3 innings of scoreless relief for the win, and Trevor Megill pitched a perfect ninth for his third save.

After the homers, Lugo surrendered only three singles for the rest of his outing. In 6 2/3 innings, he allowed three runs on six hits. Vinnie Pasquantino went 3-for-5 with three RBIs and a run for the Royals. Salvador Perez added an RBI double.

Rangers 15, Athletics 8

Marcus Semien opened the game with a homer and finished 4-for-5 with five RBIs and Texas scored 10 runs in the second inning to beat host Oakland.

Jonah Heim also had four hits and Leody Taveras added three more as the Rangers equaled their season high for runs while collecting a season-best 19 hits. Jose Urena (1-2) was the beneficiary of all the run support and picked up his first win as a Ranger. He worked five innings, allowing two runs (one earned).

Kyle McCann and Seth Brown each hit their third homer of the year for the A's. Oakland starter Ross Stripling (1-6) lasted only 1 2/3 innings, giving up 11 runs (five earned) on 10 hits.

Tigers 11, Guardians 7

Andy Ibanez clubbed a solo homer and a three-run shot during his 4-for-4 night and Ryan Vilade recorded his first three career RBIs as visiting Detroit beat Cleveland.

Tyler Holton (3-0) and three other fellow Tigers relievers held Cleveland to just three hits over seven scoreless innings.

Josh Naylor clubbed a two-run homer -- his ninth long ball of the season -- and Jose Ramirez had three hits and two RBIs for the Guardians, who had won three straight. Cleveland starter Logan Allen was charged with seven runs on seven hits and two walks in 2 1/3 innings.

Diamondbacks 6, Reds 2

Corbin Carroll drilled a three-run homer and drove in his team's first five runs and Zac Gallen threw six shutout innings, helping Arizona down host Cincinnati.

Ketel Marte went deep, his seventh homer of the year, and Kevin Newman had two hits for the Diamondbacks, who won their second game in a row.

Jonathan India belted his second homer of the season with two outs in the seventh off Arizona reliever Bryce Jarvis for the Reds' first long ball since May 1. Tyler Stephenson added his fourth homer of the year in the ninth off reliever Paul Sewald.

Phillies 10, Blue Jays 1

Bryce Harper hit a grand slam, Kody Clemens added a home run, triple and four RBIs and host Philadelphia defeated Toronto.

Bryson Stott contributed two hits, Edmundo Sosa hit an RBI triple and Nick Castellanos added an RBI double for the Phillies, who have won seven straight overall and 11 in a row at home to maintain the best record in the majors. Philadelphia starter Cristopher Sanchez (2-3) gave up six hits and one run in seven innings.

Danny Jansen had two hits for the Blue Jays. Toronto, which managed only six hits, went 0-for-7 with runners in scoring position.

Angels 9, Pirates 0

Kevin Pillar clubbed two home runs and tallied a career-high six RBIs to complement Patrick Sandoval's seven shutout innings as visiting Los Angeles pounded Pittsburgh.

Pillar, 35, went 3-for-5 and scored two runs in his fourth game with the Angels since signing with them on April 30. Logan O'Hoppe went 4-for-5 with two RBIs for Los Angeles, which outhit the Pirates 15-3. Sandoval (2-5) scattered three hits, struck out seven and walked one in his longest outing of the season.

Connor Joe, Andrew McCutchen and Edward Olivares accounted for Pittsburgh's three hits as the Pirates had their three-game winning streak snapped.

Nationals 3, Orioles 0

Trevor Williams and four relievers combined on a three-hit shutout and Washington defeated visiting Baltimore.

Joey Meneses and Jesse Winker had two hits apiece for the Nationals, who, at 18-17, are over .500 for the first time since July 2, 2021. Washington snapped a seven-game losing streak against Baltimore.

Corbin Burnes (3-2) allowed three runs on five hits over 6 1/3 innings. He struck out six and walked three for the Orioles, who had won four straight.

Rays 5, White Sox 1

Randy Arozarena and Isaac Paredes belted home runs, starting pitcher Zach Eflin broke a personal two-game losing streak and Tampa Bay handled Chicago in St. Petersburg, Fla.

Arozarena homered for the second time in three games by launching his sixth blast of the year, a two-run shot, in the third. Paredes, who was 3-for-4, clubbed his team-leading eighth long ball in the sixth for the Rays.

Paul DeJong and Korey Lee had two hits apiece as the White Sox managed just six as a team, five for singles.

Yankees 10, Astros 3

Juan Soto recorded his fourth three-hit game this season but wasn't part of the three-homer barrage that carried host New York to a win over Houston.

Alex Verdugo, Anthony Volpe and Giancarlo Stanton all homered off Astros starter Justin Verlander (1-1), with Verdugo initiating the onslaught with a three-run blast in the first.

Verlander allowed seven runs on eight hits in five innings. Yankees right-hander Luis Gil (3-1) only gave up Kyle Tucker's solo shot across six dominant innings.

Braves 4, Red Sox 2

Marcell Ozuna lined a single up the middle to score the go-ahead run in the eighth inning as Atlanta beat visiting Boston to end a three-game losing streak.

The Braves, who had scored only 20 runs over their previous eight games, added an insurance run in the eighth on Orlando Arcia's run-scoring fielder's choice.

Kutter Crawford worked six innings for the Red Sox and yielded two runs on five hits. It was the fourth consecutive start in which he pitched at least six innings.

Mariners 10, Twins 6

Cal Raleigh hit a pinch-hit grand slam in the seventh inning and Seattle scored four runs in the ninth to beat Minnesota in Minneapolis.

Mitch Haniger drove in two runs for Seattle, which evened the four-game series at one win apiece. Dylan Moore, Josh Rojas and Ty France each added one RBI for the Mariners, who won for the third time in four games.

Ryan Jeffers hit a three-run homer to lead the Twins at the plate. Trevor Larnach, Kyle Farmer and Austin Martin each had one RBI for Minnesota.

Mets 7, Cardinals 5

Pete Alonso and Brandon Nimmo drove in three runs apiece as visiting New York rallied to beat St. Louis.

Alonso, who was 1-for-29 in his previous nine games, had a two-run double and a homer. Nimmo hit a three-run homer. Mets starting pitcher Jose Butto (1-2) allowed three runs on five hits and three walks in five innings.

Alec Burleson went 3-for-5 with a homer and two RBIs for the Cardinals, who lost for the sixth time in seven games. Brendan Donovan and Lars Nootbaar also went deep for St. Louis, which lost catcher Willson Contreras to a left forearm fracture in the second inning after J.D. Martinez hit him while swinging his bat on a catcher's-interference incident.

Giants 5, Rockies 0

Kyle Harrison tossed seven innings of four-hit ball, Jung Hoo Lee had three hits and San Francisco beat Colorado in Denver.

Harrison (3-1) produced the longest outing of his two-year career, helping the Giants snap a four-game skid. Nick Ahmed had two hits for San Francisco, and LaMonte Wade Jr. had a two-run single.

Rockies starter Dakota Hudson (0-6) allowed four runs on five hits in 3 2/3 innings. Colorado took its eighth loss in nine games and is off to its worst start in franchise history (8-27).

Dodgers 8, Marlins 2

Max Muncy hit a first-inning grand slam and host Los Angeles extended its winning streak to six games with a victory over Miami.

Gavin Lux also homered while right-hander Yoshinobu Yamamoto (4-1) gave up two runs on five hits over a career-best eight innings for the Dodgers.

Jazz Chisholm Jr. hit a home run on the first pitch of the game for the Marlins, who have had an early lead on the Dodgers in two consecutive games before losing both. Bryan De La Cruz also went deep, while Edward Cabrera (1-2) gave up four runs in two innings.