Houston Astros relief pitcher Bryan Abreu earned his second hold of the season and pitched 1 1/3 innings without giving up a hit or a run. Even though he was effective, it was not a good sign for the 28-year-old's fantasy value that he entered the game in the seventh inning with two outs. He worked a scoreless eighth inning as well but gave the ball to Enyel De Los Santos to close out the game. Abreu hasn't earned a save in any of his last five appearances, giving up five runs on five hits with eight walks and six strikeouts. He seems to have been passed by De Los Santos as the preferred option for save chances, while the team awaits the return of Josh Hader (biceps) later this season. Abreu could work his way back into that role, but for now, he doesn't carry enough fantasy value for a roster spot in standard-sized mixed leagues.

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Los Angeles Angels relief pitcher Drew Pomeranz is a very intriguing speculative pickup in deep leagues, since he could be next up for the Angels after Jordan Romano has blown two save chances in New York. Pomeranz has allowed four runs on six hits in eight games this season, but he has only allowed one run in six innings over his last six appearances. He has four holds in those six games, but has not been brought into a save opportunity. Pomeranz retired four in a row before giving the ball to Romano for the ninth inning, and since that went so poorly, the Angels could be forced to shake up the roles for the end of the game in their high-leverage situations even before Kirby Yates (knee) joins the mix later this season.

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Athletics relief pitcher Joel Kuhnel got a four-out save on Wednesday night, picking up two strikeouts and retiring all four Rangers he faced to secure his third save of the year. The 31-year-old righty has given up just one hit and no runs in 4 2/3 innings this season and is a very solid option at the end of the game for the A's. With such a strong start to the year, he's a great addition from the waiver wire if you are searching for saves, even though there's no apparent reason the journeyman has been so effective after joining the team on a minor-league contract. He has been so effective, though, that he's a great grab for as long as he keeps the closer role for the Athletics.

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Milwaukee Brewers relief pitcher Abner Uribe stepped into a ninth-inning role on Wednesday night and pitched a perfect inning to secure his team's 2-1 win over the Blue Jays. Uribe retired the Jays in order with a strikeout to earn his first save of the season, and his velocity was back to where it was last season. Uribe's velocity had been down, and he gave up four runs in 6 1/3 innings in his first seven appearances before stepping up on Wednesday. The Brewers have been contemplating a closer change with Uribe and Trevor Megill both struggling, and Uribe delivered in this contest. He could secure the role going forward with more outings like this one, and if he does, he'll be a great closer option in all formats. If he's available in your league, he's a great pickup if you're searching for saves.

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Los Angeles Angels relief pitcher Jordan Romano let another game slip away in New York on Wednesday night. He came on in the ninth inning with a one-run lead and gave up two runs on two hits and a walk, while recording just one out. Romano gave up a walk-off double to Jose Caballero, taking his second blown save of the three-game series against the Yankees. Before the double, though, Romano's defense let him down when a routine pop-up dropped between Zach Neto and Oswald Peraza to start the meltdown. The 32-year-old had been perfect in four save opportunities before this series, and it will be interesting to see if he gets another chance or if the team goes another direction. Kirby Yates (knee) is nearing a return and could be part of the solution if Romano continues to struggle.

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Houston Astros relief pitcher Enyel De Los Santos worked a perfect ninth in his team's 3-1 win on Wednesday night. He picked up a pair of strikeouts against pinch-hitter Brett Sullivan and Brenton Doyle to preserve the win for Spencer Arrighetti. De Los Santos earned his second save of the season and has allowed only one run on four hits across 6 2/3 innings with six strikeouts. Josh Hader (biceps) is working his way back, but since he is likely at least a month away, De Los Santos will likely remain in the mix for a few saves along with. Bryan Abreu over the next few weeks. In deep or AL-only leagues, De Los Santos is definitely worth owning if you're searching for saves, although his long-term outlook is in more of a setup role.

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Cubs' SP Shota Imanaga recorded 11 strikeouts in 6 innings collecting the win in a 11-2 win over Philadelphia on Wednesday, Apr. 15.

Diamondbacks' DH Adrian Del Castillo had five RBIs going 2-for-5 with a home run in a 8-5 win over Baltimore on Wednesday, Apr. 15.

Reds' 1B Sal Stewart had six RBIs going 2-for-4 with two home runs in a 8-3 win over the Giants on Wednesday, Apr. 15.

Houston Astros' SP Spencer Arrighetti recorded 10 strikeouts in 6 innings collecting the win in a 3-1 win over the Rockies on Wednesday, Apr. 15.

Los Angeles Dodgers' DH Shohei Ohtani recorded 10 strikeouts in 6 innings getting the win in a 8-2 win over the Mets on Wednesday, Apr. 15.

Red Sox's SS Trevor Story had five RBIs going 2-for-4 with a home run in a 9-5 win over Minnesota on Wednesday, Apr. 15.

Cubs' 2B Nico Hoerner had five RBIs going 3-for-5 with a home run in a 11-2 win over Philadelphia on Wednesday, Apr. 15.

Across his first 77 plate appearances of 2026, Tampa Bay Rays third baseman Junior Caminero is hitting .234/.351/.406 with three home runs, six RBI, and nine runs scored. Fresh off a 45-homer season as a 21-year-old in 2025, Caminero hasn't been quite as dynamic early on this year. Still, Caminero's 19.5% strikeout rate is right in line with the 19.1% mark he posted last season. Opposing pitchers are being extra cautious this year with Caminero, as his 15.6% walk rate is nearly 10 percentage points higher than his 6.3% rate from 2025. Caminero has consistently shown the ability to make hard contact throughout his MLB career to this point, which should help him regain his power stroke over a larger sample size of at-bats. Fantasy managers should be patient with Caminero through the early portion of the season.

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Across his first 85 plate appearances of 2026, Atlanta Braves outfielder Ronald Acuna Jr. is hitting .247/.341/.384 with one home run, five RBI, six runs scored, and four stolen bases. While Acuna Jr. hasn't quite gotten his power stroke going yet, his 16.4% barrel rate suggests that it's only a matter of time before his fly balls start leaving the yard with more regularity. Acuna Jr.'s four stolen bases are also a positive sign for fantasy managers. The 28-year-old recorded just nine steals in 95 games while returning from a torn ACL in 2025, but the early push in 2026 could be a sign he has more confidence in his surgically repaired knee. While Acuna Jr.'s top-line numbers haven't been quite what fantasy managers might have hoped for so far, it's too early to panic.

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San Francisco Giants starting pitcher Landen Roupp has gotten off to a strong start to his 2026 season. Across 16 2/3 innings pitched (three starts), the 27-year-old owns a 2-1 record with a 3.24 ERA, 1.14 WHIP, and 18 strikeouts. Roupp emerged as a capable option for the Giants in 2025, recording a 3.80 ERA across 106 2/3 innings (22 starts). However, he posted an underwhelming 21.4% strikeout rate and a brutal 1.48 WHIP. Early in 2026, Roupp has upped his strikeout rate to 26.1% and has issued just five walks. If his current strand rate of 57.9% regresses closer to his career mark of 71.6%, Roupp could actually be in line to improve on his current 3.24 ERA. Based on the improvements he has shown so far this season, Roupp could be an intriguing target on the waiver wire for fantasy managers. His next start is scheduled for Thursday in Cincinnati against the Reds.

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New York Yankees manager Aaron Boone said that starting pitcher Gerrit Cole (elbow) is scheduled to make a rehab start with Double-A Somerset on Friday, per Bryan Hoch of MLB.com. The return to live game action represents a big step in Cole's recovery from Tommy John surgery, which caused him to miss the entire 2025 season. Across 95 innings (17 starts) in 2024, Cole posted an 8-5 record with a 3.41 ERA, 1.14 WHIP, and 99 strikeouts. The 35-year-old should not be expected to be the pitcher he once was at his peak, but Cole still carries clear fantasy upside once healthy. Given the long layoff, Cole will almost certainly need to make multiple rehab starts in the minor leagues. Still, he could be tracking towards an MLB return in May, barring any setbacks.

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New York Mets infielder Jorge Polanco (Achilles) is not in the lineup for his team's matchup on Wednesday against the Los Angeles Dodgers due to continued issues with Achilles bursitis, per Mike Puma of the New York Post. Puma reports that the team plans to re-evaluate him on Friday, and that Mets manager Carlos Mendoza said a trip to the injured list is on the table for Polanco. Polanco is off to a rough start to his first year in New York, hitting .179/.246/.286 with one home run, two RBI, and three runs scored across 61 plate appearances. Polanco has been in and out of the lineup due to this Achilles issue for over a week now, so an injured list stint could be the best thing for him long term. Mets outfielder MJ Melendez got the start at designated hitter in place of Polanco on Wednesday, and could be in line for more playing time if Polanco is sidelined for an extended stretch.

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New York Mets manager Carlos Mendoza said, "that's the goal," when asked by reporters whether outfielder Juan Soto (calf) would return during the team's next home stand. The Mets finish up their current road trip this weekend in Chicago before returning home next Tuesday for a three-game set against the Minnesota Twins. Soto is currently on the 10-day injured list as he recovers from a calf strain that he suffered on April 3. Across 34 plate appearances before getting hurt, the 27-year-old hit .355/.412/.516 with one home run, five RBI, and three runs scored. Once he's back in the lineup, Soto immediately profiles as a must-start fantasy outfielder. However, fantasy managers may want to prepare for limited aggressiveness on the base paths with Soto returning from a leg ailment. Soto was one of the more surprising sources of speed for fantasy managers in 2025 when he stole 38 bags.

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Los Angeles Dodgers two-way superstar Shohei Ohtani will pitch against the New York Mets on Wednesday, but he will not serve as the designated hitter, according to Buster Olney of ESPN. The Dodgers won't overdo it with Ohtani in his two-way role early on and have opted to give him a little rest while he pitches on Wednesday. As a hitter, Ohtani has gone hitless in his last seven at-bats with a run scored in the last two games. With Ohtani only pitching, catcher Dalton Rushing is serving as the DH and will hit seventh against Mets right-hander Clay Holmes. Outfielder Kyle Tucker moves into the leadoff spot for the Blue. Ohtani has gone 12 innings in his first two starts of the 2026 season, and he's yet to allow an earned run while walking four and striking out eight. Fantasy managers should be starting Ohtani the pitcher on Wednesday night against a Mets team that is really struggling offensively with All-Star outfielder Juan Soto (calf) on the injured list.

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