Guest of the League
Lineup Changes
Duffers 1 - Jeff Fuchs
| Benched | Nathan Eovaldi (P) TEX | Owner | Mon May 6 9:24am ET |
| Started P | Zach Eflin (P) TB | Owner | Mon May 6 9:24am ET |
| Started P | Tyler Glasnow (P) LAD | Owner | Mon May 6 9:24am ET |
| Benched | MacKenzie Gore (P) WSH | Owner | Mon May 6 9:24am ET |
GAMERS -
| Started OF | Bryan Reynolds (OF) PIT | Owner | Mon May 6 3:06am ET |
| Benched | Michael Harris II (OF) ATL | Owner | Mon May 6 3:06am ET |
| Started U | Nathaniel Lowe (1B) TEX | Owner | Mon May 6 3:05am ET |
| Benched | Bryan Reynolds (OF) PIT | Owner | Mon May 6 3:05am ET |
| Benched | Lourdes Gurriel Jr. (OF) ARI | Owner | Mon May 6 3:04am ET |
| Started OF | Anthony Santander (1B, OF) BAL | Owner | Mon May 6 3:04am ET |
Good Tryers VI -
| Started P | Andres Munoz (P) SEA | Owner | Mon May 6 1:55pm ET |
| Started C | Elias Diaz (C) COL | Owner | Mon May 6 10:12am ET |
| Benched | Javier Assad (P) CHC | Owner | Mon May 6 10:12am ET |
| Started P | Tyler Anderson (P) LAA | Owner | Mon May 6 10:12am ET |
| Started P | Logan Allen (P) CLE | Owner | Mon May 6 10:12am ET |
| Benched | Cristopher Sanchez (P) PHI | Owner | Mon May 6 8:15am ET |
| Started P | Javier Assad (P) CHC | Owner | Mon May 6 5:53am ET |
| Started P | Kirby Yates (P) TEX | Owner | Mon May 6 5:53am ET |
| Started P | Mason Miller (P) OAK | Owner | Mon May 6 5:53am ET |
| Benched | Ryan Pepiot (P) TB | Owner | Sun May 5 1:17pm ET |
| Benched | Luis Severino (P) NYM | Owner | Sun May 5 1:17pm ET |
| Benched | Jason Foley (P) DET | Owner | Sun May 5 1:16pm ET |
| Started P | Alexis Diaz (P) CIN | Owner | Wed May 1 5:46pm ET |
| Benched | Jon Gray (P) TEX | Owner | Wed May 1 5:46pm ET |
| Benched | Javier Assad (P) CHC | Owner | Wed May 1 5:45pm ET |
| Started P | Justin Verlander (P) HOU | Owner | Wed May 1 5:45pm ET |
Great Bambino - Matt Bremser
| Benched | Dansby Swanson (SS) CHC | Owner | Mon May 6 8:56am ET |
| Started SS | Jeremy Pena (SS) HOU | Owner | Mon May 6 8:56am ET |
| Benched | Jordan Montgomery (P) ARI | Owner | Mon May 6 8:55am ET |
| Started P | Dane Dunning (P) TEX | Owner | Mon May 6 8:55am ET |
| Started P | Erick Fedde (P) CWS | Owner | Mon May 6 8:55am ET |
| Benched | Kyle Finnegan (P) WSH | Owner | Mon May 6 8:55am ET |
LastMango - Michael Madsen
| No starting lineup changes performed this week. |
Mayweather 4 - Ryan Porter
| Started OF | Willi Castro (2B, SS, 3B, OF) MIN | Owner | Mon May 6 10:20am ET |
| Started P | Ronel Blanco (P) HOU | Owner | Mon May 6 10:20am ET |
| Started U | Salvador Perez (C, 1B) KC | Owner | Mon May 6 8:59am ET |
| Benched | Anthony Volpe (SS) NYY | Owner | Mon May 6 8:59am ET |
| Started P | Chris Bassitt (P) TOR | Owner | Mon May 6 8:59am ET |
| Benched | Grayson Rodriguez (P) BAL | Owner | Mon May 6 8:59am ET |
| Started 3B | Ryan McMahon (2B, 3B) COL | Owner | Mon May 6 8:59am ET |
| Benched | Ryan McMahon (2B, 3B) COL | Owner | Mon May 6 8:59am ET |
| Started 2B | Luis Arraez (1B, 2B) SD | Owner | Mon May 6 8:59am ET |
Night Owls - Mike Marin
| Started P | John Means (P) BAL | Owner | Mon May 6 11:37am ET |
| Started P | Josh Hader (P) HOU | Owner | Sun May 5 5:22pm ET |
| Benched | Brandon Pfaadt (P) ARI | Owner | Sun May 5 5:22pm ET |
Rosin Bags - Michael Marsden
| Benched | Marcus Stroman (P) NYY | Owner | Mon May 6 9:20am ET |
| Started P | Triston McKenzie (P) CLE | Owner | Mon May 6 9:20am ET |
| Started 2B | Christopher Morel (2B, 3B, OF) CHC | Owner | Mon May 6 9:19am ET |
| Started P | Raisel Iglesias (P) ATL | Owner | Sat May 4 7:44pm ET |
| Benched | Trevor Rogers (P) MIA | Owner | Sat May 4 7:44pm ET |
| Started 2B | Nolan Gorman (2B, 3B) STL | Owner | Sat May 4 7:43pm ET |
| Started SS | Xander Bogaerts (2B, SS) SD | Owner | Sat May 4 7:43pm ET |
| Benched | Xander Bogaerts (2B, SS) SD | Owner | Sat May 4 7:43pm ET |
| Benched | Trea Turner (SS) PHI | Owner | Sat May 4 7:43pm ET |
TampaRealTor$ - Jonathan Urban
| Started P | Craig Kimbrel (P) BAL | Owner | Mon May 6 10:23am ET |
| Benched | Evan Phillips (P) LAD | Owner | Mon May 6 10:23am ET |
| Started U | Starling Marte (OF) NYM | Owner | Mon May 6 8:20am ET |
| Benched | Ozzie Albies (2B) ATL | Owner | Mon May 6 8:20am ET |
Zion's Minions - Rick Hashi
| Started OF | Alex Verdugo (OF) NYY | Owner | Mon May 6 10:05am ET |
| Started OF | Colton Cowser (OF) BAL | Owner | Mon May 6 8:45am ET |
| Benched | Jesse Winker (OF) WSH | Owner | Mon May 6 8:45am ET |
| Benched | Logan Webb (P) SF | Owner | Mon May 6 8:43am ET |
| Started P | Yu Darvish (P) SD | Owner | Mon May 6 8:43am ET |
| Benched | Colton Cowser (OF) BAL | Owner | Sun May 5 11:51pm ET |
| Started OF | Jesse Winker (OF) WSH | Owner | Sun May 5 11:51pm ET |
| Started OF | Colton Cowser (OF) BAL | Owner | Sun May 5 10:06am ET |
| Benched | Jesse Winker (OF) WSH | Owner | Sun May 5 10:06am ET |
| Started OF | Jackson Merrill (SS, OF) SD | Owner | Sat May 4 11:15pm ET |
| Benched | Colton Cowser (OF) BAL | Owner | Sat May 4 11:15pm ET |
| Benched | Matt Olson (1B) ATL | Owner | Sat May 4 11:15pm ET |
| Started 1B | Justin Turner (1B, 2B) TOR | Owner | Sat May 4 11:15pm ET |
