Indianapolis Colts running back Jonathan Taylor (ankle) will have his 21-day practice window opened following the conclusion of Week 4, per NFL Network's Ian Rapoport. At any point when a player is eligible to return from the PUP list, the team can trigger their practice window, giving them 21 days to activate the player or rule the player out for the rest of the season. Assuming the Colts don't want to sideline Taylor for the year, it's looking like he'll return sometime over the next three weeks. Rapoport notes that Taylor is "fully healthy," which means he could be back sooner rather than later. He also writes that "there have been no recent trade talks between the Colts and other teams" surrounding Taylor, who voiced his displeasure with ownership and requested a trade this past summer.

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San Francisco 49ers running back Elijah Mitchell (knee) is expected to be inactive for Week 4 versus the Arizona Cardinals, per NFL Network's Ian Rapoport. Mitchell was listed as questionable after missing practice on Friday. The only 49ers running back worth starting in fantasy football is the dangerous Christian McCaffrey. However, Jordan Mason and Tyrion Davis-Price can also expected to earn some snaps in Mitchell's absence.

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Arizona Cardinals wide receiver Marquise Brown (thumb) is expected to be active for Sunday's game against the San Francisco 49ers, per NFL Network's Tom Pelissero. Brown had been listed as questionable after practicing in a limited capacity on Friday. Despite catching passes from Joshua Dobbs, Brown is off to a solid start this season, catching 14 passes for 143 yards and two touchdowns. Even against a solid 49ers defense, Brown is a fantasy WR3.

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Las Vegas Raiders rookie quarterback Aidan O'Connell is expected to draw the start in Week 4 versus the Los Angeles Chargers, per NFL Network's Ian Rapoport. With Jimmy Garoppolo (concussion) ruled out, the expectation was that veteran Brian Hoyer would handle quarterback duties on Sunday. Instead, it'll be the Purdue product making his NFL debut. The 25-year-old flashed potential in the preseason, but regular-season defenses are a whole new beast. He's not on the fantasy radar, and the likes of Davante Adams, Josh Jacobs, and Jakobi Meyers will see their fantasy value take a hit. On the other hand, the Chargers' defense becomes a solid streamer.

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San Francisco 49ers wide receiver Deebo Samuel (ribs, knee) is expected to be active for Week 4 versus the Arizona Cardinals. He had been listed as questionable after upgrading to a limited participant in practice on Friday. The 27-year-old is off to a solid start this season, totaling 247 yards and one touchdown. Despite competing for touches with the likes of Christian McCaffrey, George Kittle, and Brandon Aiyuk, Samuel has significant standalone value as a solid fantasy WR2.

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Jacksonville Jaguars wide receiver Jamal Agnew (quadricep) is officially inactive for Week 4 versus the Atlanta Falcons. Originally listed as questionable, the veteran was expected to be a game-time decision. In the end, though, he's inactive. The 28-year-old had four catches for 49 yards plus a lost fumble last Sunday. Calvin Ridley and Christian Kirk will continue to lead the receiver corps in the absence of Agnew and Zay Jones (knee).

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Atlanta Falcons running back Cordarrelle Patterson (thigh) is officially active for Week 4 against the Jacksonville Jaguars. He'll make his season debut in London after being listed as questionable. Patterson contributed an impressive 817 scrimmage yards and eight touchdowns through 13 games last season, but he's expected to have a much smaller role in 2023 now that Bijan Robinson and Tyler Allgeier have already established themselves as the top two options out of the backfield.

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According to ESPN's Jeremy Fowler, the Raiders "are leaning" toward starting quarterback Aidan O'Connell on Sunday against the Los Angeles Chargers. Jimmy Garoppolo (head) didn't clear concussion protocol and was ruled out on Saturday. While veteran Brian Hoyer is on the roster and ready to take over under center, O'Connell may get a chance to make a name for himself in Week 4. That said, fantasy managers shouldn't feel comfortable starting the rookie. However, he could prove useful for those in deep, Superflex formats versus a struggling Chargers defense.

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According to NFL Media's Ian Rapoport, "there is now optimism" that quarterback Derek Carr (shoulder) will play in Sunday's meeting with Tampa Bay. The signal-caller suffered an AC sprain in his shoulder in Week 3 and was expected to miss time. While that still could happen, the latest update suggests he could return sooner than expected. If Carr can suit up for this one, there's always a chance of re-injury. But if he doesn't, Jameis Winston will be under center versus his former team.

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According to ESPN's Adam Schefter, Los Angeles Rams tight end Tyler Higbee (Achilles) will likely suit up for Sunday's meeting with the Colts. The 30-year-old has played well this season while Cooper Kupp (hamstring) works toward a return, catching 11 of his 15 targets for 132 yards. Although Higbee is still without a touchdown during the 2023-24 campaign, he's played well enough to draw consideration from fantasy managers in Week 4.

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Cleveland Browns tight end David Njoku (face, hands) remains questionable ahead of Sunday's game against the Ravens. He suffered burns to his face and hands during an incident involving a fire pit at his home. Although Njoku insists he'll be out there for the AFC North clash with Baltimore, the team "needs to see if he can get his helmet on." It's unknown how severe the burns are. However, considering the 27-year-old hasn't been productive while healthy this season, catching 10 passes for 92 yards and no touchdowns, he's not an ideal fantasy option in Week 4 if he is active.

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According to ESPN's Kimberley A. Martin, Cleveland Browns quarterback Deshaun Watson is expected to play in the Week 4 AFC North bout with Baltimore. The veteran suffered a shoulder injury in the win over the Titans but recently downplayed the severity of the ailment. Still, head coach Kevin Stefanski and the training staff will see how Watson feels during warmups before making an official decision. Assuming he suits up, he's a must-start in most fantasy setups.

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The Kansas City Chiefs defense is an excellent streaming option for the second straight week after netting 11 fantasy points versus the dysfunctional Chicago Bears last Sunday. New York Jets quarterback Zach Wilson, who the Chiefs will do battle with in Week 4, harbors the third-lowest yards per attempt (5.6), and is scoring a meek 9.0 fantasy points per game. Wilson's QBR is anchored as the league's second-lowest figure (26.7) with an NFL-worst 57.0 passer rating over the course of three contests. The Chiefs have notched seven sacks and given up only 19 points since All-Pro pass-rusher Chris Jones returned in Week 2 from a contract-related holdout. Fantasy managers should tee up KC's D as a set-and-forget option on Sunday night.

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Kansas City Chiefs kicker Harrison Butker is 14-for-14 on all kicking attempts so far in three 2023 games. The 28-year-old made a considerable five extra points amid last Sunday's 41-10 drubbing of the Chicago Bears. Butker represents a great bet for a busy day on Sunday against a New York Jets defense that has a propensity to bend but not break. Gang Green has allowed an NFL-high 12 field-goal tries en route to the highest fantasy points per game to kickers (13). The seventh-year man could be called upon often if the Chiefs get ahead of the Jets, and fantasy managers can safely start him as a top-tier choice on Sunday.

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Kansas City Chiefs wide receiver Rashee Rice emerged with five catches (seven targets) for 59 yards in last Sunday's trouncing of the Chicago Bears. The 2023 second-rounder might be the team's most interesting wideout to watch in Week 4 against the New York Jets with no other member of the receiving corps yet to stand out. Rice is paralleling the embattled Kadarius Toney (toe) in terms of target rate (36.8%), commanding 14 on just 38 routes run this year. The 23-year-old ranks 10th among WRs with 2.84 yards per route run, which is an area Toney is vastly struggling in. Rice will aim to keep creating separation at a high level and he might be pinging the radar as a possible deep-league WR4/FLEX choice on Sunday night. He should at least be atop fantasy watchlists, if not already stashed on benches, to monitor his progress.

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Kansas City Chiefs wide receiver Skyy Moore looks like the most startable fantasy choice of the team's mishmash wideout crew in Week 4 against the New York Jets, but that isn't saying very much. The 22-year-old rebounded from a catchless season opener to haul in seven of his 13 targets for 112 yards and touchdown in his last two outings. Moore spends a solid chunk of time in the slot, so he may face off less regularly with Gang Green's feared duo of Sauce Gardner and D.J. Reed than his perimeter teammates. Though, it's worth noting both of whom have struggled a bit out of 2023's gates. With Kadarius Toney (toe) off the injury report, Moore is only on the WR3/4 edge in deep leagues until his role becomes more pronounced.

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Kansas City Chiefs running back Jerick McKinnon managed two touchdowns on five touches (28 total yards) in Week 3's hammering of the Chicago Bears. While the 31-year-old's workload, or lack thereof, renders him hard to immediately thrust into fantasy lineups, it's an undeniably favorable matchup in Week 4 against a New York Jets defense that has been picked on for the most targets (27) and third-most catches (20) to RBs this year. Isiah Pacheco easily remains the best bet for carries as a top-24 play in this crowded backfield also including Clyde Edwards-Helaire, but McKinnon shows some signs of PPR RB3 life for Sunday night. Even so, he appears almost entirely touchdown-reliant while handling a scant 13.6% of the backfield's collective carries plus targets.

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Kansas City Chiefs tight end Travis Kelce put the cherry on top with a third-quarter touchdown in Week 3's blowout win over the Chicago Bears. The 33-year-old missed the season opener, but he's immediately picked back up on his dominant ways with a TE-best 31.5% target rate (17 targets on 54 routes run). Kelce will be tested in Week 4 against the stiff New York Jets defense, but there's plenty of room for optimism despite the rigid matchup for KC's offense. With a dynamic cornerback tandem in New York's backend, their Achilles heel defensively is easily shown in defending enemy TEs, which dates back to 2022. Gang Green's defense displays a mouthwatering matchup for Kelce after being penetrated for the third-highest fantasy points per game to the position (16.97) over three games. The eight-time Pro Bowler should have fantasy managers anticipating a late-slate hammer play on Sunday Night Football in season-long and DFS settings.

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San Francisco 49ers wide receiver Willie Snead IV has been promoted to the active roster on Saturday. This news comes with wideouts Jauan Jennings (shin) and Deebo Samuel (knee, ribs) both uncertain to play. That being said, Snead could end up seeing some playing time if one of both of these receivers are sidelined. The 30-year-old was with the 49ers last season, so he is familiar with the system. Despite that, it's unlikely that Snead has much if any fantasy value for this Week 4 matchup against the Arizona Cardinals.

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Los Angeles Chargers linebacker Joey Bosa (hamstring, toe) has been ruled out for the upcoming Week 4 matchup against the Las Vegas Raiders. The 28-year-old missed three straight practices this week due to lingering injuries. That being said, the Chargers are deciding to play it safe and rest Bosa for Sunday's game. The Chargers have a bye week after this game, so hopefully that will give Bosa enough time to get healthy. This is a tough blow to the Chargers defense that will already be without safety Derwin James Jr. (hamstring) as well.

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