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Players: Emmanuel Sanders, Marquise Goodwin, Jimmy Garoppolo, George Kittle, Dante Pettis, Andy Isabella, Kyler Murray

San Francisco 49ers quarterback Jimmy Garoppolo (10) passes against Seattle Seahawks defensive tackle Quinton Jefferson (99) during the second half of an NFL football game in Santa Clara, Calif., Monday, Nov. 11, 2019. (AP Photo/Tony Avelar)


Arizona Cardinals quarterback Kyler Murray (1) throws a pass against the Tampa Bay Buccaneers during the first half of an NFL football game Sunday, Nov. 10, 2019, in Tampa, Fla. (AP Photo/Jason Behnken)


SANTA CLARA, Calif. (AP) After nothing but success the first eight games of the season, the San Francisco 49ers now are learning to deal with failure.

The Niners' perfect season was derailed last week with an overtime loss to the Seattle Seahawks when San Francisco was unable to overcome a litany of offensive miscues.

The 49ers (8-1) will look to get back on the winning track Sunday when they host the Arizona Cardinals (3-6-1) for the second time in three weeks.

''I think we have a good mindset with it,'' said quarterback Jimmy Garoppolo, who had his worst day of the season in the 27-24 loss. ''Everyone was in here yesterday working on the day off. Today it's just a sense of urgency in the building. It's good to see that.''

San Francisco committed three turnovers, allowed five sacks and struggled to get much of anything going consistently on the ground or through the air against Seattle.

The 49ers had season lows in yards rushing (87) and yards per attempt passing (4.7) on a night that star tight end George Kittle was out with an injury and No. 1 receiver Emmanuel Sanders left with injured ribs in the first quarter.

San Francisco is using that performance as a teaching tool for the rest of the season.

''You learn from the good and you learn more from the bad,'' tackle Mike McGlinchey said. ''It's a huge step in the right direction for us to be able take as many blows as we did and play as poorly as we did and still have a chance, not only one chance but multiple chances to win that game. That's a testament to how our defense played. ... We need to do a better job on the offensive side of the ball to make sure we reward their work.''

The Cardinals are stumbling toward their bye week, having lost three straight games after a promising start to the first season under coach Kliff Kingsbury and rookie quarterback Kyler Murray.

One of those losses was two weeks ago when Arizona fell 28-25 at home to the 49ers, a performance that gives the Cardinals confidence that if they can fix some mistakes they can compete with the first-place Niners.

''I don't think we played our best game,'' Murray said. ''I know personally, if we just go out and execute - they know what we do, we know what they do - if we go out and execute, we should be in good shape.''

MISSING TARGETS

The Niners' offense was done in by the absence of Kittle and Sanders last week. San Francisco scored 10 points on the opening two drives when Sanders was healthy and then just six more on offense the rest of the game. With no consistent receiving threats, the Seahawks were able to load up against the run and allow only 3.2 yards per carry. Kendrick Bourne had two key drops for San Francisco, while Dante Pettis and Marquise Goodwin combined for no catches on six targets.

ISABELLA ARRIVES

Arizona has relied on a variety of playmakers this season and the latest to make big plays is rookie receiver Andy Isabella. The second-round pick out of UMass had an 88-yard touchdown catch against the 49ers in the first meeting between the teams on Oct. 31. He has six catches for 174 yards over the past three games after not even being targeted in the season's first seven games. Kingsbury said Isabella has been improving steadily all season.

''It's been trending that way for a while,'' he said. ''We've had him inside, had him outside, and I think now the comfort level, having him outside more so, has really helped his development recently.''

MAN IN THE MIDDLE

The defensive star of the game for the 49ers last week was middle linebacker Fred Warner, who stepped up his performance in his first game since fellow starting linebacker Kwon Alexander suffered a season-ending torn pectoral muscle. Warner had 10 tackles, the first two sacks of his career, one forced fumble and a pass defensed.

''He gets us in and out of everything,'' coach Kyle Shanahan said. ''He has to make a ton of calls. He's definitely our quarterback out there and I think he does it as good as anyone I've seen.''

DEFENSIVE TROUBLES

Arizona's defense ranks 31st out of 32 teams in points allowed (281), total yards allowed per game (412.5) and passing yards allowed per game (286.5). The Cardinals have given up at least 21 points in all 10 games this season but never have given up more than 38. Linebacker Chandler Jones has been one of the bright spots with 11 1/2 sacks and five forced fumbles. Three-time All-Pro cornerback Patrick Peterson returned from a six-game suspension last month but hasn't had much of an impact. Kingsbury said the Cardinals had bouts of poor tackling in last week's 30-27 loss to Tampa Bay.

''There were some shoulders being thrown,'' Kingsbury said. ''We have to be better in those situations.''

BLIND SIDE

The 49ers again will be without starting left tackle Joe Staley, who will be out a couple of weeks after undergoing surgery on a broken finger. Staley broke a bone in his leg in Week 2 and missed the next six games. He then got hurt in his return to the lineup. With Staley unable to go, rookie Justin Skule is expected to move back into the lineup.

''I thought he did a very good job,'' Shanahan said of Skule. ''He came in there and stepped it up right away. Did a good job in his first game and I thought he got better each week.''

Player Notes
Mike Boone Dec 15 10:40pm ET

Minnesota Vikings running back Mike Boone had a great game in Week 15's blowout win over the Los Angeles Chargers. The undrafted second-year back out of Cincinnati rushed 13 times for 56 yards and two touchdowns in the win, finding the end zone for the first time in his young career. Boone worked as the lead back in the second half with starter Dalvin Cook (shoulder) out, and he looked just as explosive as he did when he dominated in the preseason this year. Cook was ruled out very quickly and Alexander Mattison (ankle) could be looking at an extended absence, as evidenced by the Vikings signing Tony Brooks-James to their practice squad last Wednesday. Boone is a priority pickup with Cook and Mattison ailing as he would be squarely on the RB2 radar in Week 16 if they are both ruled out. Stay tuned for updates on all three Vikings' backs.

From RotoBaller

Minnesota Vikings Dec 15 10:30pm ET

The Minnesota Vikings Defense stepped up in a big way in Week 15's 39-10 victory over the Los Angeles Chargers. They tallied a whopping seven takeaways (three interceptions and four fumble recoveries), three sacks, and a touchdown as the Chargers looked flustered all game long. The most notable play was Danielle Hunter's strip-sack and forced fumble that was scooped by Ifeadi Odenigbo and returned 56 yards for a touchdown in the second quarter. The defense took control of this game from the get-go, but the secondary continued its stretch of subpar play and Xavier Rhodes was replaced by Mike Hughes for a good portion of the game. The Vikings Defense will be a risky option in Week 16's home matchup with the Green Bay Packers.

From RotoBaller

Dan Bailey Dec 15 10:20pm ET

Minnesota Vikings kicker Dan Bailey had himself a game in Week 15, going 4-for-4 on field goals attempts and knocking in three extra points in a 39-10 win over the Los Angeles Chargers. Bailey hit from 26, 27, 38, and 44 yards and is now sitting at an impressive 92% field goal percentage for the season. Bailey is a recommended start in Week 16's home matchup against the rival Green Bay Packers.

From RotoBaller

Tyrell Williams Dec 15 10:13pm ET

Oakland Raiders WR Tyrell Williams caught two of his three targets for 45 yards, including a 40-yard touchdown, in a 20-16 loss to the Jacksonville Jaguars in Week 15.

Fantasy Spin: After scoring in five consecutive games to open the year, Williams had gone six straight games without a touchdown prior to the Week 15 contests. He's an all-or-nothing, touchdown-dependent flex option.

From TheHuddle

Irv Smith Jr. Dec 15 10:10pm ET

Minnesota Vikings tight end Irv Smith Jr. caught two of three targets for eight yards and a touchdown in Week 15's convincing win over the Los Angeles Chargers. His score was a one-yarder off of play-action to open up the game's scoring in the first quarter. It was the second touchdown of the promising rookie's career, with the first coming back in Week 11. That being said, Smith Jr. is still working behind Kyle Rudolph and does not receive enough volume to be in consideration for fantasy rosters heading into Week 16 against the Green Bay Packers.

From RotoBaller

Chris Conley Dec 15 10:03pm ET

Jacksonville Jaguars WR Chris Conley caught four of his eight targets for 49 yards and two touchdowns in a 20-16 win over the Oakland Raiders in Week 15.

Fantasy Spin: Conley has been good for a handful of grabs and around 50 yards most weeks, but he entered the game with just two touchdowns. At best, he's a risky flex option.

From TheHuddle

Christian McCaffrey Dec 15 10:03pm ET

Carolina Panthers RB Christian McCaffrey rushed 19 times for 87 yards and two touchdowns in Week 15 against the Seattle Seahawks. He also added eight grabs for 88 yards on 10 targets.

Fantasy Spin: McCaffrey continues to put up amazing numbers, win or lose. He will be in the conversation for No. 1 overall fantasy pick heading into the 2020 season. The Panthers travel to meet the Colts in Week 16.

From TheHuddle

D.J. Moore Dec 15 10:03pm ET

Carolina Panthers WR D.J. Moore finished with eight catches for 113 yards on 12 targets in Week 15 against the Seattle Seahawks.

Fantasy Spin: That's four 100-yard games in the past seven outings, and at least 75 yards in all seven during the span. He is a legit WR2 in PPR formats, and a nice WR3 or flex option in standard play. The Panthers travel to meet the Colts in Week 16.

From TheHuddle

Kirk Cousins Dec 15 10:00pm ET

Minnesota Vikings quarterback Kirk Cousins completed 19-of-25 for 207 yards and a touchdown in a dominating Week 15 win over the Los Angeles Chargers. He also added three rushes for 14 yards. He did toss an interception, but the blame for that one lays squarely on backup running back Ameer Abdullah. Cousins was very efficient again this week, but he simply didn't need to put up big fantasy numbers as the Vikings held a two-possession lead and heavily emphasized the ground game for most of the second half. His lone touchdown pass came on a one-yarder to Irv Smith Jr. to open up the game. Cousins will be on the low-end QB1 radar for Week 16's home matchup against the Green Bay Packers.

From RotoBaller

Washington Redskins Dec 15 10:00pm ET

The Washington Redskins Defense ended a three-game streak of playing admirably in Sunday's loss to the Eagles. Carson Wentz launched three touchdowns through the air, while Miles Sanders racked up 172 yards from scrimmage and two touchdowns of his own. The Redskins didn't help their bottom line with turnovers and sacks the way they have been of late, getting to Wentz just twice and recovering one forced fumble. The end result was 31 points surrendered defensively and not enough complementary stats to account for those points in fantasy lineups. Washington's defense will have a chance to bounce back against the Giants at home next week.

From RotoBaller

Kyle Rudolph Dec 15 10:00pm ET

Minnesota Vikings tight end Kyle Rudolph caught all three of his targets for 48 yards in Week 15's 39-10 win over the Los Angeles Chargers. Rudolph finished second in targets and receiving yardage on the team this week as he surprisingly remained relevant despite Adam Thielen's return. Rookie Irv Smith Jr. vultured a one-yard touchdown in the first quarter, but Rudolph's continued involvement in the offense is definitely encouraging. Continue to view him as a touchdown-dependent TE2 heading into Week 16 against the Green Bay Packers.

From RotoBaller

Josh Gordon Dec 15 9:53pm ET

Seattle Seahawks WR Josh Gordon had one grab for 58 yards on his only target in Week 15 against the Carolina Panthers and he also threw a pass and was picked off.

Fantasy Spin: Gordon is a big-play receiver capable of being a fantasy contributor. He just still isn't 100 percent part of the offense yet. Avoid him outside of deeper fantasy leagues in Week 16 against the Cardinals.

From TheHuddle

Leonard Fournette Dec 15 9:53pm ET

Jacksonville Jaguars RB Leonard Fournette rushed 15 times for 42 yards and caught five of his seven targets for 31 yards in a 20-16 win over the Oakland Raiders in Week 15.

Fantasy Spin: Fournette has been held to 50 rushing yards or less in three straight games, but fortunately for fantasy owners, his increased role in the passing game this year has allowed him to salvage decent point totals more often than not. At worst, he should be a volume-based RB2.

From TheHuddle

Bobby Wagner Dec 15 9:53pm ET

Seattle Seahawks LB Bobby Wagner totaled 10 tackles with two passes defensed in Week 15 against the Carolina Panthers.

From TheHuddle

Luke Kuechly Dec 15 9:53pm ET

Carolina Panthers LB Luke Kuechly totaled 17 tackles with two quarterback hits in Week 15 against the Seattle Seahawks.

From TheHuddle

Kelvin Harmon Dec 15 9:50pm ET

Washington Redskins wide receiver Kelvin Harmon was largely absent from his team's offensive attack for the second week in a row on Sunday. Harmon caught two passes on three targets and accumulated just 22 total yards in a loss to the Eagles. This is a discouraging trend for Harmon after he appeared to be carving out a spot in the pecking order in late November and early December. In any case, the fantasy season is at the point where owners just have to trust what their eyes are telling them. Harmon has dropped too far off the map to be considered a realistically safe bet in the late stages of the fantasy playoffs.

From RotoBaller

Tyler Lockett Dec 15 9:43pm ET

Seattle Seahawks WR Tyler Lockett posted eight receptions for 120 yards and a touchdown in Week 14 against the Carolina Panthers on a team-high nine targets.

Fantasy Spin: Lockett had been banged up recently, battling a shin contusion, but he is back just in time for fantasy owners. The Seahawks face the Arizona Cardinals in Week 16.

From TheHuddle

Chris Carson Dec 15 9:43pm ET

Seattle Seahawks RB Chris Carson rushed 24 times for 133 yards and two touchdowns in Week 15 against the Carolina Panthers.

Fantasy Spin: With Rashaad Penny out of the picture it's the Chris Carson Show, and he more than looked capable of handling the entire workload. He is in line for a huge fantasy performance in Week 16 against the Arizona Cardinals.

From TheHuddle

Adrian Peterson Dec 15 9:43pm ET

Washington Redskins RB Adrian Peterson rushed 16 times for 66 yards and a touchdown and caught all three of his targets for 25 yards in a 37-27 loss to the Philadelphia Eagles in Week 15.

Fantasy Spin: An injury to Derrius Guice has Peterson leading the Washington backfield once again, and he has topped 75 total yards and scored in each of the past three games. He's a legitimate RB2 candidate heading into a favorable Week 16 matchup against the New York Giants.

From TheHuddle

Austin Seibert Dec 15 9:40pm ET

Cleveland Browns kicker Austin Seibert hit one of his two field goals in a 38-24 loss to the Arizona Cardinals in Week 15. Seibert also tacked on three extra points in the loss. The rookie kicker missed a 45-yard field goal at the beginning of the fourth quarter, his fourth missed field goal of the season. In all, Seibert has been a reliable kicker for the Browns this season, although their poor offense has limited his scoring chances. Seibert will not be a recommended fantasy option in Week 16 against a tough Baltimore Ravens Defense.

From RotoBaller