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Players: Emmanuel Sanders, Marquise Goodwin, Jimmy Garoppolo, George Kittle, Dante Pettis, Andy Isabella, Kyler Murray

San Francisco 49ers quarterback Jimmy Garoppolo (10) passes against Seattle Seahawks defensive tackle Quinton Jefferson (99) during the second half of an NFL football game in Santa Clara, Calif., Monday, Nov. 11, 2019. (AP Photo/Tony Avelar)


Arizona Cardinals quarterback Kyler Murray (1) throws a pass against the Tampa Bay Buccaneers during the first half of an NFL football game Sunday, Nov. 10, 2019, in Tampa, Fla. (AP Photo/Jason Behnken)


SANTA CLARA, Calif. (AP) After nothing but success the first eight games of the season, the San Francisco 49ers now are learning to deal with failure.

The Niners' perfect season was derailed last week with an overtime loss to the Seattle Seahawks when San Francisco was unable to overcome a litany of offensive miscues.

The 49ers (8-1) will look to get back on the winning track Sunday when they host the Arizona Cardinals (3-6-1) for the second time in three weeks.

''I think we have a good mindset with it,'' said quarterback Jimmy Garoppolo, who had his worst day of the season in the 27-24 loss. ''Everyone was in here yesterday working on the day off. Today it's just a sense of urgency in the building. It's good to see that.''

San Francisco committed three turnovers, allowed five sacks and struggled to get much of anything going consistently on the ground or through the air against Seattle.

The 49ers had season lows in yards rushing (87) and yards per attempt passing (4.7) on a night that star tight end George Kittle was out with an injury and No. 1 receiver Emmanuel Sanders left with injured ribs in the first quarter.

San Francisco is using that performance as a teaching tool for the rest of the season.

''You learn from the good and you learn more from the bad,'' tackle Mike McGlinchey said. ''It's a huge step in the right direction for us to be able take as many blows as we did and play as poorly as we did and still have a chance, not only one chance but multiple chances to win that game. That's a testament to how our defense played. ... We need to do a better job on the offensive side of the ball to make sure we reward their work.''

The Cardinals are stumbling toward their bye week, having lost three straight games after a promising start to the first season under coach Kliff Kingsbury and rookie quarterback Kyler Murray.

One of those losses was two weeks ago when Arizona fell 28-25 at home to the 49ers, a performance that gives the Cardinals confidence that if they can fix some mistakes they can compete with the first-place Niners.

''I don't think we played our best game,'' Murray said. ''I know personally, if we just go out and execute - they know what we do, we know what they do - if we go out and execute, we should be in good shape.''

MISSING TARGETS

The Niners' offense was done in by the absence of Kittle and Sanders last week. San Francisco scored 10 points on the opening two drives when Sanders was healthy and then just six more on offense the rest of the game. With no consistent receiving threats, the Seahawks were able to load up against the run and allow only 3.2 yards per carry. Kendrick Bourne had two key drops for San Francisco, while Dante Pettis and Marquise Goodwin combined for no catches on six targets.

ISABELLA ARRIVES

Arizona has relied on a variety of playmakers this season and the latest to make big plays is rookie receiver Andy Isabella. The second-round pick out of UMass had an 88-yard touchdown catch against the 49ers in the first meeting between the teams on Oct. 31. He has six catches for 174 yards over the past three games after not even being targeted in the season's first seven games. Kingsbury said Isabella has been improving steadily all season.

''It's been trending that way for a while,'' he said. ''We've had him inside, had him outside, and I think now the comfort level, having him outside more so, has really helped his development recently.''

MAN IN THE MIDDLE

The defensive star of the game for the 49ers last week was middle linebacker Fred Warner, who stepped up his performance in his first game since fellow starting linebacker Kwon Alexander suffered a season-ending torn pectoral muscle. Warner had 10 tackles, the first two sacks of his career, one forced fumble and a pass defensed.

''He gets us in and out of everything,'' coach Kyle Shanahan said. ''He has to make a ton of calls. He's definitely our quarterback out there and I think he does it as good as anyone I've seen.''

DEFENSIVE TROUBLES

Arizona's defense ranks 31st out of 32 teams in points allowed (281), total yards allowed per game (412.5) and passing yards allowed per game (286.5). The Cardinals have given up at least 21 points in all 10 games this season but never have given up more than 38. Linebacker Chandler Jones has been one of the bright spots with 11 1/2 sacks and five forced fumbles. Three-time All-Pro cornerback Patrick Peterson returned from a six-game suspension last month but hasn't had much of an impact. Kingsbury said the Cardinals had bouts of poor tackling in last week's 30-27 loss to Tampa Bay.

''There were some shoulders being thrown,'' Kingsbury said. ''We have to be better in those situations.''

BLIND SIDE

The 49ers again will be without starting left tackle Joe Staley, who will be out a couple of weeks after undergoing surgery on a broken finger. Staley broke a bone in his leg in Week 2 and missed the next six games. He then got hurt in his return to the lineup. With Staley unable to go, rookie Justin Skule is expected to move back into the lineup.

''I thought he did a very good job,'' Shanahan said of Skule. ''He came in there and stepped it up right away. Did a good job in his first game and I thought he got better each week.''

Player Notes
Diontae Johnson Dec 16 12:00am ET

Pittsburgh Steelers wide receiver Diontae Johnson tied for the team lead in catches in Week 15, coming down with five catches for 62 yards. He was targeted seven times, good for second on the team. Johnson made some big plays in this one and should be primed for another good game next week against the Jets secondary.

From RotoBaller

Nick Vannett Dec 16 12:00am ET

Pittsburgh Steelers tight end Nick Vannett played well in Week 15, catching five passes for 40 yards. He was targeted six times. With Vance McDonald (concussion) forced to miss the game, Vannett was the main tight end for the Steelers offense. His five catches tied for the team lead in catches. He'll be a solid TE2 with a decent floor for as long as McDonald is out.

From RotoBaller

Pittsburgh Steelers Dec 16 12:00am ET

The Pittsburgh Steelers Defense was okay against the Buffalo Bills in a Week 15 loss. They allowed 17 points, but recorded a sack and an interception. The Steelers defensive unit will have a better matchup in Week 16 against a scuffling New York Jets team. They'll be a solid fantasy option for fantasy championship week.

From RotoBaller

Devlin Hodges Dec 15 11:50pm ET

Pittsburgh Steelers quarterback Devlin Hodges did not play well in a Week 15 loss to the Buffalo Bills. Hodges completed 23 of his 38 pass attempts for 202 yards and one touchdown. He threw four interceptions, some at critical times in the game. The Steelers take on the Jets next week and should fare slightly better through the air, but Hodges still won't be much of a fantasy option for the fantasy championships.

From RotoBaller

Buffalo Bills Dec 15 11:50pm ET

The Buffalo Bills Defense was excellent in a Week 15 victory over the Pittsburgh Steelers. They recovered a fumble, collected four interceptions, allowed just 10 points, and got four sacks. It was an all-around impressive performance by Buffalo, who will have a tougher contest next week against the New England Patriots.

From RotoBaller

James Conner Dec 15 11:50pm ET

Pittsburgh Steelers running back James Conner ran the ball just eight times in Week 15, gaining 42 yards. He added four catches for nine yards and a touchdown. Conner's touchdown came on an 11-yard pass from Devlin Hodges. Despite his success on the ground (5.3 ypc), the Steelers kept the ball in the air far too often in this game. Conner will face the Jets next week and should at least get more than eight rushing attempts.

From RotoBaller

James Washington Dec 15 11:50pm ET

Pittsburgh Steelers wide receiver James Washington caught five passes in Week 15, gaining 83 scoreless yards. Washington was targeted 11 times, which led the Steelers. His five catches tied for the lead on the team with two other players, and his 83 yards were tops on the team as well. It was an overall strong game by Washington against a tough Buffalo Bills Defense. He'll have the Jets Defense to deal with next week.

From RotoBaller

John Brown Dec 15 11:40pm ET

Buffalo Bills wide receiver John Brown caught seven passes in a Week 15 win, gaining 99 yards. Brown led the team in both catches, targets, and yards, all by a huge margin. Brown had an excellent start to the season but had faded a bit in previous weeks. Given the tough matchup against the Steelers Defense this week, he was not a widely recommended fantasy option. He played very well however, and could surprise again next week despite an incredibly tough matchup against the New England Patriots.

From RotoBaller

Tyler Kroft Dec 15 11:40pm ET

Buffalo Bills tight end Tyler Kroft caught his only target in a Week 15 win over the Steelers, coming down with a 14-yard touchdown. The Bills did very little in the passing game outside of John Brown, but Kroft's touchdown was a critical one, helping to send the Bills to the playoffs for the first time in a while. Kroft won't be a fantasy option next week against the New England Patriots.

From RotoBaller

Cole Beasley Dec 15 11:40pm ET

Buffalo Bills wide receiver Cole Beasley was targeted six times in a Week 15 win, but caught only one pass for just six yards. Beasley was somewhat hyped coming into this one, but did next to nothing. The Bills passing game in general didn't really do anything outside of John Brown, however. Beasley gets an even tougher matchup next week against the New England Patriots.

From RotoBaller

Kenyan Drake Dec 15 11:33pm ET

Arizona Cardinals RB Kenyan Drake rushed 22 times for 137 yards and four touchdowns and caught one pass for nine yards in a 38-24 win over the Cleveland Browns in Week 15.

Fantasy Spin: After a couple of lackluster outings, Drake erupted for the best game of his career. He has become a workhorse since being acquired by Arizona, logging at least 14 touches in all six games. He'll be a fringe RB2 option with upside against the Seattle Seahawks in Week 16.

From TheHuddle

Devin Singletary Dec 15 11:30pm ET

Buffalo Bills running back Devin Singletary ran the ball 21 times in a Week 15 win, piling up 87 yards. He also caught two passes, but gained just two yards total. Singletary was solid in this one but didn't make any huge plays against a tough Steelers Defense. He was certainly the featured back though, out-touching Frank Gore 23-10. He'll have a tough matchup against the stout Patriots run defense next week on Saturday.

From RotoBaller

Josh Allen Dec 15 11:30pm ET

Buffalo Bills quarterback Josh Allen was responsible for two touchdowns in Week 15 against the Pittsburgh Steelers. He completed 13 of his 25 pass attempts for 139 yards, one touchdown, and one interception. He also ran the ball seven times for 28 yards and a touchdown on the ground. His passing score came on a 14-yard pass to Tyler Kroft and his rushing score came on a one-yard scamper. Allen led his team to a win against a tough Steelers Defense, but it certainly wasn't his best fantasy performance of the season.

From RotoBaller

Frank Gore Dec 15 11:30pm ET

Buffalo Bills running back Frank Gore ran the ball 10 times in a Week 15 win, gaining just 15 yards total. Gore was thoroughly out-touched and out-played by Devin Singletary, who gained 89 total yards on 23 touches. It'll be an even tougher matchup next week against the New England Patriots, where Gore shouldn't be much of a fantasy consideration.

From RotoBaller

Jarvis Landry Dec 15 11:23pm ET

Cleveland Browns WR Jarvis Landry caught five of his eight targets for 23 yards in a 38-24 loss to the Arizona Cardinals in Week 15.

Fantasy Spin: It was Landry's lowest yardage total of the year, and it couldn't have come at a worst time with the fantasy playoffs in full swing. He could be in a for another rough outing in Week 16 when he faces the Baltimore Ravens.

From TheHuddle

Odell Beckham Jr. Dec 15 10:53pm ET

Cleveland Browns WR Odell Beckham Jr. caught eight of his 13 targets for 66 yards in a 38-24 loss to the Arizona Cardinals in Week 15.

Fantasy Spin: Beckham delivered one of his better games of the year, and while it was encouraging to see him targeted 13 times, he is going to have a hard time backing up this performance in Week 16 when he faces a Baltimore defense that held him to 20 yards earlier in the year.

From TheHuddle

Nick Chubb Dec 15 10:43pm ET

Cleveland Browns RB Nick Chubb rushed 17 times for 127 yards and a touchdown and caught all three of his targets for 21 yards in a 38-24 loss to the Arizona Cardinals in Week 15.

Fantasy Spin: Chubb continues to be one of the steadiest backs in the league, and he is up to seven 100-yard rushing efforts on the year, including three in his last four games. He's a plug-and-play RB1.

From TheHuddle

Kareem Hunt Dec 15 10:43pm ET

Cleveland Browns RB Kareem Hunt rushed four times for 14 yards and caught eight of his nine targets for 62 yards in a 38-24 loss to the Arizona Cardinals in Week 15.

Fantasy Spin: Nick Chubb is the top dog in Cleveland's backfield, but Hunt typically sees about 10-15 touches and has been able to stay in the flex conversation in PPR formats thanks to his involvement in the passing game.

From TheHuddle

Mike Boone Dec 15 10:40pm ET

Minnesota Vikings running back Mike Boone had a great game in Week 15's blowout win over the Los Angeles Chargers. The undrafted second-year back out of Cincinnati rushed 13 times for 56 yards and two touchdowns in the win, finding the end zone for the first time in his young career. Boone worked as the lead back in the second half with starter Dalvin Cook (shoulder) out, and he looked just as explosive as he did when he dominated in the preseason this year. Cook was ruled out very quickly and Alexander Mattison (ankle) could be looking at an extended absence, as evidenced by the Vikings signing Tony Brooks-James to their practice squad last Wednesday. Boone is a priority pickup with Cook and Mattison ailing as he would be squarely on the RB2 radar in Week 16 if they are both ruled out. Stay tuned for updates on all three Vikings' backs.

From RotoBaller

Minnesota Vikings Dec 15 10:30pm ET

The Minnesota Vikings Defense stepped up in a big way in Week 15's 39-10 victory over the Los Angeles Chargers. They tallied a whopping seven takeaways (three interceptions and four fumble recoveries), three sacks, and a touchdown as the Chargers looked flustered all game long. The most notable play was Danielle Hunter's strip-sack and forced fumble that was scooped by Ifeadi Odenigbo and returned 56 yards for a touchdown in the second quarter. The defense took control of this game from the get-go, but the secondary continued its stretch of subpar play and Xavier Rhodes was replaced by Mike Hughes for a good portion of the game. The Vikings Defense will be a risky option in Week 16's home matchup with the Green Bay Packers.

From RotoBaller